Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Zhenpeng Zhuang"'
Autor:
Weikai Ge, Shixue Gou, Xiaozhu Zhao, Qin Jin, Zhenpeng Zhuang, Yu Zhao, Yanhui Liang, Zhen Ouyang, Xiaoyi Liu, Fangbing Chen, Hui Shi, Haizhao Yan, Han Wu, Liangxue Lai, Kepin Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract The CRISPR/Cas9 system has shown great potential for treating human genetic diseases through gene therapy. However, there are concerns about the safety of this system, specifically related to the use of guide-free Cas9. Previous studies have
Externí odkaz:
https://doaj.org/article/d5821f95cdce4ed0a2e9fbac9fb1c3f0
Autor:
Ting Lan, Huangyao Chen, Chengcheng Tang, Yuhui Wei, Yang Liu, Jizeng Zhou, Zhenpeng Zhuang, Quanjun Zhang, Min Chen, Xiaoqing Zhou, Yue Chi, Jinling Wang, Yu He, Liangxue Lai, Qingjian Zou
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 890-897 (2023)
Prime editor (PE) is a versatile genome editing tool that does not need extra DNA donors or inducing double-strand breaks. However, in vivo implementation of PE remains a challenge because of its oversized composition. In this study, we screened out
Externí odkaz:
https://doaj.org/article/8627ee1167194107a2672a4ab7f37199
Autor:
Qin Jin, Xiaoyi Liu, Zhenpeng Zhuang, Jiayuan Huang, Shixue Gou, Hui Shi, Yu Zhao, Zhen Ouyang, Zhaoming Liu, Lei Li, Junjie Mao, Weikai Ge, Fangbing Chen, Manya Yu, Yezhi Guan, Yinghua Ye, Chengcheng Tang, Ren Huang, Kepin Wang, Liangxue Lai
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-25 (2023)
Abstract Background CRISPR-based toolkits have dramatically increased the ease of genome and epigenome editing. SpCas9 is the most widely used nuclease. However, the difficulty of delivering SpCas9 and inability to modulate its expression in vivo hin
Externí odkaz:
https://doaj.org/article/110960d35b9b427bbaadfb937e744aa5
Autor:
Jingke Xie, Xingyun Huang, Xia Wang, Shixue Gou, Yanhui Liang, Fangbing Chen, Nan Li, Zhen Ouyang, Quanjun Zhang, Weikai Ge, Qin Jin, Hui Shi, Zhenpeng Zhuang, Xiaozhu Zhao, Meng Lian, Jiaowei Wang, Yinghua Ye, Longquan Quan, Han Wu, Kepin Wang, Liangxue Lai
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background Many favorable traits of crops and livestock and human genetic diseases arise from multiple single nucleotide polymorphisms or multiple point mutations with heterogeneous base substitutions at the same locus. Current cytosine or a
Externí odkaz:
https://doaj.org/article/5974bfd9c0c64e52a24cfd1869de793b
Autor:
Ting Lan, Yuling Zheng, Yangyang Suo, Yuhui Wei, Hui Shi, Quanmei Yan, Zhenpeng Zhuang, Huangyao Chen, Quanjun Zhang, Nana Fan, Yu Zhao, Zhen Ouyang, Chengdan Lai, Zhaoming Liu, Jizeng Zhou, Chengcheng Tang, Nam-Hyung Kim, Qingjian Zou, Xiaomin Wang
Publikováno v:
Journal of Genetics and Genomics. 50:212-215
Autor:
Qin, Jin, Xiaoyu, Yang, Shixue, Gou, Xiaoyi, Liu, Zhenpeng, Zhuang, Yanhui, Liang, Hui, Shi, Jiayuan, Huang, Han, Wu, Yu, Zhao, Zhen, Ouyang, Quanjun, Zhang, Zhaoming, Liu, Fangbing, Chen, Weikai, Ge, Jingke, Xie, Nan, Li, Chengdan, Lai, Xiaozhu, Zhao, Jiaowei, Wang, Meng, Lian, Lei, Li, Longquan, Quan, Yinghua, Ye, Liangxue, Lai, Kepin, Wang
Publikováno v:
Science China Life Sciences. 65:2269-2286
Inducible expression systems are indispensable for precise regulation and in-depth analysis of biological process. Binary Tet-On system has been widely employed to regulate transgenic expression by doxycycline. Previous pig models with tetracycline r
Autor:
Yingying Li, Hai Wang, Huangyao Chen, Yuan Liao, Shixue Gou, Quanmei Yan, Zhenpeng Zhuang, Hao Li, Jiaowei Wang, Yangyang Suo, Ting Lan, Yang Liu, Yu Zhao, Qingjian Zou, Tao Nie, Xiaoyan Hui, Liangxue Lai, Donghai Wu, Nana Fan
Publikováno v:
The FASEB Journal. 36
Autor:
Yingying, Li, Hai, Wang, Huangyao, Chen, Yuan, Liao, Shixue, Gou, Quanmei, Yan, Zhenpeng, Zhuang, Hao, Li, Jiaowei, Wang, Yangyang, Suo, Ting, Lan, Yang, Liu, Yu, Zhao, Qingjian, Zou, Tao, Nie, Xiaoyan, Hui, Liangxue, Lai, Donghai, Wu, Nana, Fan
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 36(11)
Obesity is among the strongest risk factors for type 2 diabetes (T2D). The CREBRF missense allele rs373863828 (p. Arg457Gln, p. R457Q) is associated with increased body mass index but reduced risk of T2D in people of Pacific ancestry. To investigate
Autor:
Yanhui Liang, Jingke Xie, Quanjun Zhang, Xiaomin Wang, Shixue Gou, Lihui Lin, Tao Chen, Weikai Ge, Zhenpeng Zhuang, Meng Lian, Fangbing Chen, Nan Li, Zhen Ouyang, Chengdan Lai, Xiaoyi Liu, Lei Li, Yinghua Ye, Han Wu, Kepin Wang, Liangxue Lai
Publikováno v:
Nucleic acids research. 50(9)
Establishing saturated mutagenesis in a specific gene through gene editing is an efficient approach for identifying the relationships between mutations and the corresponding phenotypes. CRISPR/Cas9-based sgRNA library screening often creates indel mu
Autor:
Yinghua Ye, Liangxue Lai, Zhenpeng Zhuang, Hui Shi, Nan Li, Jingke Xie, Xiaozhu Zhao, Kepin Wang, Shixue Gou, Han Wu, Meng Lian, Fangbing Chen, Yi Yang, Yanhui Liang, Weikai Ge, Xingyun Huang, Qin Jin, Jiaowei Wang
Publikováno v:
Journal of Genetics and Genomics. 48:92-95