Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Zhenming Du"'
Autor:
Sharmistha Sinha, Zhenming Du, Panchanan Maiti, Frank-Gerrit Klärner, Thomas Schrader, Chunyu Wang, Gal Bitan
Publikováno v:
ACS Chemical Neuroscience. 13:2666-2666
Publikováno v:
Expressed Protein Ligation ISBN: 9781071604335
Methods Mol Biol
Methods Mol Biol
The autocatalytic process of protein splicing is facilitated by an intein, which interrupts flanking polypeptides called exteins. The mechanism of protein splicing has been studied by overexpression in E. coli of intein fusion proteins with nonnative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87974a57cbc88e193863f64c44816714
https://doi.org/10.1007/978-1-0716-0434-2_4
https://doi.org/10.1007/978-1-0716-0434-2_4
Publikováno v:
Chemical Communications. 53:1370-1373
Sulfur dioxide (SO2) is being recognized as a possible endogenous gasotransmitter with importance on par with that of NO, CO, and H2S. Herein we describe a series of SO2 prodrugs that are activated for SO2 release via a bioorthogonal click reaction.
Publikováno v:
Chemical communications (Cambridge, England). 53(8)
Sulfur dioxide (SO2) is being recognized as a possible endogenous gasotransmitter with importance on par with that of NO, CO, and H2S. Herein we describe a series of SO2 prodrugs that are activated for SO2 release via a bioorthogonal click reaction.
Autor:
Julie N. Reitter, Kathryn M. Colelli, Zhenming Du, Chunyu Wang, Jennie E. Williams, Michelle D. Marieni, Wen Chen, Alice Hsu, Kenneth V. Mills, Jiajing Liu, Clayton D. Albracht
Publikováno v:
Journal of Biological Chemistry. 286:38638-38648
Protein splicing is a precise self-catalyzed process in which an intein excises itself from a precursor with the concomitant ligation of the flanking polypeptides (exteins). Protein splicing proceeds through a four-step reaction but the catalytic mec
Publikováno v:
Journal of Molecular Biology. 400:755-767
Inteins mediate protein splicing, which has found many applications in biotechnology and protein engineering. A single valine-to-leucine mutation (V67L) can globally enhance splicing and related cleavage reactions in minimized Mycobacterium tuberculo
Autor:
Georges Belfort, Zhenming Du, Brian Pereira, Yangzhong Liu, Philip Shemella, Saroj Nayak, Marlene Belfort, Chunyu Wang, Scott A. McCallum
Publikováno v:
Journal of the American Chemical Society. 131:11581-11589
Protein splicing is a precise autocatalytic process in which an intein excises itself from a precursor with the concomitant ligation of the flanking sequences. Protein splicing occurs through acid-base catalysis in which the ionization states of acti
Autor:
Chunyu Wang, Gal Bitan, Kirsten McDaniel, Aida Attar, Zhenming Du, Thomas Schrader, Dahabada H. J. Lopes, Eric Y. Hayden, Sumit Mittal, Heinz Bandmann, Som Dutt, Gayatri Nair, Frank-Gerrit Klärner, Kenny Bravo-Rodriguez, Elsa Sanchez-Garcia
Publikováno v:
Lopes, DHJ; Attar, A; Nair, G; Hayden, EY; Du, Z; McDaniel, K; et al.(2015). Molecular Tweezers Inhibit Islet Amyloid Polypeptide Assembly and Toxicity by a New Mechanism. ACS Chemical Biology, 10(6), 1555-1569. doi: 10.1021/acschembio.5b00146. UCLA: Retrieved from: http://www.escholarship.org/uc/item/05n960rx
© 2015 American Chemical Society. In type-2 diabetes (T2D), islet amyloid polypeptide (IAPP) self-associates into toxic assemblies causing islet β-cell death. Therefore, preventing IAPP toxicity is a promising therapeutic strategy for T2D. The mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44c47e3d856909fa0f88320b4fdacfa
http://www.escholarship.org/uc/item/05n960rx
http://www.escholarship.org/uc/item/05n960rx
Publikováno v:
Biomolecular NMR Assignments. 8:279-281
The Hedgehog (Hh) signaling pathway plays important roles in embryonic growth and patterning in different organisms. Abnormal activity of the Hh signaling pathway has been associated to cancers, holoprosencephaly and autism spectrum disorders. The ba