Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Zhenmin Liang"'
Autor:
Ruoqi Peng, Sriram Sridhar, Gaurav Tyagi, Jonathan E Phillips, Rosario Garrido, Paul Harris, Lisa Burns, Lorena Renteria, John Woods, Leena Chen, John Allard, Palanikumar Ravindran, Hans Bitter, Zhenmin Liang, Cory M Hogaboam, Chris Kitson, David C Budd, Jay S Fine, Carla M T Bauer, Christopher S Stevenson
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e59348 (2013)
The preclinical model of bleomycin-induced lung fibrosis, used to investigate mechanisms related to idiopathic pulmonary fibrosis (IPF), has incorrectly predicted efficacy for several candidate compounds suggesting that it may be of limited value. As
Externí odkaz:
https://doaj.org/article/f1de7e184b004255ba62f718b13adc00
Autor:
Christopher Kitson, Yonglin Ren, Hang Zeng, Jeremy Deguzman, Julie DeMartino, Shannon Hamilton, Zhenmin Liang, David C. Budd, Christopher S. Stevenson, Subramanium Apparsundaram, Carla M. T. Bauer, Maria E. Fuentes, Ann F. Hoffman, Xiaoyan Tang, Ruoqi Peng
Publikováno v:
Molecular Pharmacology. 83:283-293
Epigenetic alterations, such as histone acetylation, regulate the signaling outcomes and phenotypic responses of fibroblasts after growth factor stimulation. The bromodomain and extra-terminal domain-containing proteins (Brd) bind to acetylated histo
Autor:
Robert Francis Kester, Linda Marcus, Marek M. Kabat, Lida Qi, Wang Ka, Michael Pignatello, Wendy Lea Corbett, Cheryl Spence, Franz M. Matschinsky, Lisa M. Garofalo, Roumen Nikolaev Radinov, Ramakanth Sarabu, David J Moore, Yi Ren, Nancy-Ellen Haynes, Zhenmin Liang, Fred Thomas Bizzarro, Darryl W. Hilliard, John Tengi, Wanping Geng, Stanley D. Hutchings, Thomas G. Steele, Joseph Grimsby, Mark T. Dvorozniak, Joseph F. Grippo, Kevin Richard Guertin, Paige Erin Mahaney, Jagdish Kumar Racha
Publikováno v:
Journal of Medicinal Chemistry. 55:7021-7036
Glucokinase (GK) activation as a potential strategy to treat type 2 diabetes (T2D) is well recognized. Compound 1, a glucokinase activator (GKA) lead that we have previously disclosed, caused reversible hepatic lipidosis in repeat-dose toxicology stu
Autor:
Zhenmin Liang
Publikováno v:
Bioanalysis. 4:1227-1234
Ionization matrix effects are one of the most difficult issues in LC–MS bioanalysis that are without a good and universal solution. Most people in the field are aware of it, but some are not sure how to deal with it. Many laboratories do not routin
Publikováno v:
Journal of Chromatography B. 878:2307-2313
High quality, ultra-fast bioanalytical LC/MS/MS methods were developed using short columns packed with fused-core particles and high (1.0-3.0 mL/min) flow rates. For more than two years, at flow rates up to 3.0 mL/min, using 0.33 min non-ballistic gr
Autor:
Lisa Burns, David C. Budd, Paul Harris, John Woods, Jay S. Fine, Lorena Renteria, Hans Bitter, Zhenmin Liang, Leena Chen, Christopher S. Stevenson, Rosario Garrido, Gaurav Tyagi, Sriram Sridhar, Cory M. Hogaboam, Carla M. T. Bauer, Ruoqi Peng, Jonathan E. Phillips, Palanikumar Ravindran, Chris Kitson, John Allard
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 4, p e59348 (2013)
PLoS ONE, Vol 8, Iss 4, p e59348 (2013)
The preclinical model of bleomycin-induced lung fibrosis, used to investigate mechanisms related to idiopathic pulmonary fibrosis (IPF), has incorrectly predicted efficacy for several candidate compounds suggesting that it may be of limited value. As
Autor:
Gaurav Tyagi, Rosario Garrido, John Woods, Paul Harris, Jonathan E. Phillips, Lisa Burns, Sriram Sridhar, Ruoqi Peng, Zhenmin Liang, Jay S. Fine, Christopher S. Stevenson
Publikováno v:
D71. ANIMAL MODELS OF LUNG FIBROSIS: BLEO AND BEYOND.
Publikováno v:
Analytical Chemistry. 66:850-855
The ultrahigh-resolution capabilities of Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) have been demonstrated for accurate mass measurements of complex hydrocarbon mixtures. Ultrahigh resolution is achievable over a wide mas
Autor:
Isabel Santos, Noémia Marques, António Pires de Matos, Alan G. Marshall, David A. Weil, Zhenmin. Liang, Joaquim Marçalo
Publikováno v:
Scopus-Elsevier
CIÊNCIAVITAE
CIÊNCIAVITAE
Autor:
Alan G. Marshall, Zhenmin. Liang
Publikováno v:
Applied Spectroscopy. 44:766-775
It is desirable to be able to predict the precision of a repeated measurement, based on the result of a single measurement and knowledge of the noise level in the original (time-domain) data. We have previously shown that precision in determination o