Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Zhenkang Chen"'
Autor:
Abhimanyu Garg, Wee-Teik Keng, Zhenkang Chen, Adwait Amod Sathe, Chao Xing, Pavithira Devi Kailasam, Yanqiu Shao, Nicholas P. Lesner, Claire B. Llamas, Anil K. Agarwal, Prashant Mishra
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
Multiple genetic loci have been reported for progeroid syndromes. However, the molecular defects in some extremely rare forms of progeria have yet to be elucidated. Here, we report a 21-year-old man of Chinese ancestry who has an autosomal recessive
Externí odkaz:
https://doaj.org/article/486f4ee4357c45cca2ea1e35adcccde2
Autor:
Nicholas P Lesner, Xun Wang, Zhenkang Chen, Anderson Frank, Cameron J Menezes, Sara House, Spencer D Shelton, Andrew Lemoff, David G McFadden, Janaka Wansapura, Ralph J DeBerardinis, Prashant Mishra
Publikováno v:
eLife, Vol 11 (2022)
Mitochondrial electron transport chain (ETC) dysfunction due to mutations in the nuclear or mitochondrial genome is a common cause of metabolic disease in humans and displays striking tissue specificity depending on the affected gene. The mechanisms
Externí odkaz:
https://doaj.org/article/bc53e8466ccf4687be0151852c83aa36
Autor:
Zhenkang Chen, Yangbo Hu, Bridgette M. Cumming, Pei Lu, Lipeng Feng, Jiaoyu Deng, Adrie J.C. Steyn, Shiyun Chen
Publikováno v:
Cell Reports, Vol 16, Iss 9, Pp 2512-2524 (2016)
During the course of infection, Mycobacterium tuberculosis (Mtb) is exposed to diverse redox stresses that trigger metabolic and physiological changes. How these stressors are sensed and relayed to the Mtb transcriptional apparatus remains unclear. H
Externí odkaz:
https://doaj.org/article/455f9526773e416e81c3ea086dc806f3
Autor:
Guodong Wang, Qi Li, Junjie Xu, Shuai Zhao, Rui Zhou, Zhenkang Chen, Wentong Jiang, Xue Gao, Shuang Zhou, Zhiyu Chen, Quanzhi Sun, Chengyuan Ma, Lin Chen, Bihan Shi, Ying Guo, Haiyan Wang, Xia Wang, Huaiye Li, Tao Cai, Yibing Wang, Zhineng Chen, Fengchao Wang, Qinghua Liu
Publikováno v:
The Journal of Neuroscience. 42:5617-5640
Classical forward and reverse mouse genetics require germline mutations and, thus, are unwieldy to study sleep functions of essential genes or redundant pathways. It is also time-consuming to conduct electroencephalogram/electromyogram-based mouse sl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d76172cc404c5891f6c95668b69fff0
https://doi.org/10.1523/jneurosci.0089-22.2022
https://doi.org/10.1523/jneurosci.0089-22.2022
Autor:
Zhenkang Chen, Bogdan Bordieanu, Rushendhiran Kesavan, Nicholas P. Lesner, Siva Sai Krishna Venigalla, Spencer D. Shelton, Ralph J. DeBerardinis, Prashant Mishra
Publikováno v:
Science Advances. 9
Myopathies secondary to mitochondrial electron transport chain (ETC) dysfunction can result in devastating disease. While the consequences of ETC defects have been extensively studied in culture, little in vivo data are available. Using a mouse model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1eaf534f4464365d23b70aed02afd9
https://doi.org/10.1126/sciadv.add3216
https://doi.org/10.1126/sciadv.add3216
Autor:
Nicholas P Lesner, Xun Wang, Zhenkang Chen, Anderson Frank, Cameron J Menezes, Sara House, Spencer D Shelton, Andrew Lemoff, David G McFadden, Janaka Wansapura, Ralph J DeBerardinis, Prashant Mishra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcf2dc2433a81ea5ccfc626aa09ce9cb
https://doi.org/10.7554/elife.80919.sa2
https://doi.org/10.7554/elife.80919.sa2
Autor:
Abhimanyu Garg, Wee-Teik Keng, Zhenkang Chen, Adwait Amod Sathe, Chao Xing, Pavithira Devi Kailasam, Yanqiu Shao, Nicholas P. Lesner, Claire B. Llamas, Anil K. Agarwal, Prashant Mishra
Publikováno v:
The Journal of clinical investigation. 132(23)
Multiple genetic loci have been reported for progeroid syndromes. However, the molecular defects in some extremely rare forms of progeria have yet to be elucidated. Here, we report a 21-year-old man of Chinese ancestry who has an autosomal recessive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad09711b9161c27770ef3230cfa90742
https://pubmed.ncbi.nlm.nih.gov/36282599
https://pubmed.ncbi.nlm.nih.gov/36282599
Autor:
Nicholas P. Lesner, Xun Wang, Zhenkang Chen, Anderson Frank, Cameron Menezes, Sara House, Spencer D. Shelton, David G. McFadden, Janaka Wansapura, Ralph J. DeBerardinis, Prashant Mishra
SummaryMitochondrial electron transport chain (ETC) dysfunction due to mutations in the nuclear or mitochondrial genome is a common cause of metabolic disease in humans, and displays striking tissue specificity depending on the affected gene. The mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddffc93b602ad9f3a6ee9b2e48a37e3b
https://doi.org/10.1101/2021.07.15.452466
https://doi.org/10.1101/2021.07.15.452466
Publikováno v:
European journal of public health. 29(6)
Background The purpose of the study was to construct a general model of the competencies required by Chinese public health physicians. This study is intended to lay the foundation for promoting reform of public health education in China, and may help
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9013063abaa8942960d274870703f6
https://pubmed.ncbi.nlm.nih.gov/30945732
https://pubmed.ncbi.nlm.nih.gov/30945732
Publikováno v:
Molecular Microbiology. 102:107-120
Mycobacterium tuberculosis adopts various strategies to cope with oxidative stress during infection. Transcriptional regulators, including σ factors, make important contributions to this stress response, but how these proteins cooperate with each ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce8085991d15c38f13c08c0469b97d61
https://doi.org/10.1111/mmi.13449
https://doi.org/10.1111/mmi.13449