Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Zhenjun Deng"'
Autor:
Aoife O'Brien, Andrew Stevenson, Lucy Barrett, Nicholas B. Lawler, Nicole Hortin, Zhenjun Deng, Amira Allahham, Fabio Quondamatteo, Nicole Smith, K. Swaminathan Iyer, Fiona M. Wood, Mark W. Fear
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e38016- (2024)
Background: Dupuytren's disease (DD) is a fibro-proliferative disorder of unknown aetiology. Previous studies have implicated multiple WNT signalling genes/proteins in Dupuytren pathology, including WNT4. However, it is not yet clear whether WNT sign
Externí odkaz:
https://doaj.org/article/44eae25ddc004ba2a79c6b3b91872db9
Autor:
Yixiu Zhong, Youfan Zhang, Aijiao Yu, Zhiwen Zhang, Zhenjun Deng, Kaifen Xiong, Qi Wang, Jianglin Zhang
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Exosomes, ranging from 40 to 160 nm in diameter, are extracellular lipid bilayer microvesicles that regulate the body’s physiological and pathological processes and are secreted by cells that contain proteins, nucleic acids, amino acids and other m
Externí odkaz:
https://doaj.org/article/8d44edf4d908463abb49599b08d85a60
Autor:
Nutan Chaudhari, Alison D. Findlay, Andrew W. Stevenson, Tristan D. Clemons, Yimin Yao, Amar Joshi, Sepidar Sayar, Gordon Wallace, Suzanne Rea, Priyanka Toshniwal, Zhenjun Deng, Philip E. Melton, Nicole Hortin, K. Swaminathan Iyer, Wolfgang Jarolimek, Fiona M. Wood, Mark W. Fear
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Scars are a significant problem caused by excess collagen in the skin. Here the authors develop a topical drug that reduces collagen stability and leads to improved scar appearance and stiffness in preclinical models.
Externí odkaz:
https://doaj.org/article/c8f42b004a044203b08d7a2b33f65895
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundAlthough lipid metabolism has been proven to play a key role in the development of cancer, its significance in uveal melanoma (UM) has not yet been elucidated in the available literature.MethodsTo identify the expression patterns of lipid m
Externí odkaz:
https://doaj.org/article/f439e036d85d42948c95380847ed0ad7
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Recent studies have demonstrated that N6-methyladenosine (m6A), the most abundant, dynamic, and reversible epigenetic RNA modification in eukaryotes, is regulated by a series of enzymes, including methyltransferases (writers), demethylases (erasers),
Externí odkaz:
https://doaj.org/article/38d796fd6cd54e1197b76f1ac0c1863f
Autor:
Nutan Chaudhari, Alison D. Findlay, Andrew W. Stevenson, Tristan D. Clemons, Yimin Yao, Amar Joshi, Sepidar Sayyar, Gordon Wallace, Suzanne Rea, Priyanka Toshniwal, Zhenjun Deng, Philip E. Melton, Nicole Hortin, K. Swaminathan Iyer, Wolfgang Jarolimek, Fiona M. Wood, Mark W. Fear
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/6ec0d2fc95844e03a9d3ce21271b20a1
Autor:
Ian L. Chin, Yu Suk Choi, Fiona M. Wood, Manon Subilia, Mark W. Fear, Zhenjun Deng, Andrew W. Stevenson, Cecilia M Prêle, Nicole Hortin
Publikováno v:
Journal of Dermatological Science. 104:11-20
Background Fibroblasts found in keloid tissues are known to present an altered sensitivity to microenvironmental stimuli. However, the impact of changes in extracellular matrix stiffness on phenotypes of normal fibroblasts (NFs) and keloid fibroblast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f9981c1165a075a44e5e928c456f27
https://doi.org/10.1016/j.jdermsci.2021.09.002
https://doi.org/10.1016/j.jdermsci.2021.09.002
Autor:
Andrew W. Stevenson, Amira Allahham, Fiona M. Wood, Cecilia M Prêle, Mark W. Fear, Zhenjun Deng
Publikováno v:
Experimental dermatologyREFERENCES. 30(8)
Keloid scarring is a fibroproliferative disorder of the skin with unknown pathophysiology, characterised by fibrotic tissue that extends beyond the boundaries of the original wound. Therapeutic options are few and commonly ineffective, with keloids v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecfafcf7f9ab5d3a8e92da8ee121f9f
https://pubmed.ncbi.nlm.nih.gov/34152651
https://pubmed.ncbi.nlm.nih.gov/34152651
Autor:
Amira Allahham, Steven E Mutsaers, Mark W. Fear, Cecilia M Prêle, Fiona M. Wood, Zhenjun Deng, Yu Suk Choi
Publikováno v:
The international journal of biochemistrycell biology. 126
Pulmonary fibrosis is characterised by excessive scarring in the lung which leads to compromised lung function, serious breathing problems and in some diseases, death. It includes several lung disorders with idiopathic pulmonary fibrosis (IPF) the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14abefae5758b5e241a9b6ae343247f9
https://pubmed.ncbi.nlm.nih.gov/32668329
https://pubmed.ncbi.nlm.nih.gov/32668329
Publikováno v:
Molecular Diagnosis & Therapy. 20:449-455
Melanoma is a common skin cancer associated with ultraviolet light exposure and genetic variance. However, the etiology and molecular mechanisms of melanoma remain unknown. Recent studies have shown that microRNAs (miRNAs) can play key roles in the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e88341f958580c85b011437dbaa608
https://doi.org/10.1007/s40291-016-0219-y
https://doi.org/10.1007/s40291-016-0219-y