Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Zhenhua SHAO"'
Autor:
Xin Chen, Kexin Wang, Jianfang Chen, Chao Wu, Jun Mao, Yuanpeng Song, Yijing Liu, Zhenhua Shao, Xuemei Pu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Allosteric drugs offer a new avenue for modern drug design. However, the identification of cryptic allosteric sites presents a formidable challenge. Following the allostery nature of residue-driven conformation transition, we propose a state
Externí odkaz:
https://doaj.org/article/585d508369294ffd998b10f17db2e8a5
Autor:
Lin Cheng, Zhuang Miao, Sicen Liu, Zhe Li, Hong Fu, Chanjuan Xu, Shilong Hu, Chang Zhao, Yuxuan Liu, Tiantian Zhao, Wencheng Liu, Heli Wang, Runduo Liu, Wei Yan, Xiangdong Tang, Jianfeng Liu, Zhenhua Shao, Bowen Ke
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Delta opioid receptor (δOR) plays a pivotal role in modulating human sensation and emotion. It is an attractive target for drug discovery since, unlike Mu opioid receptor, it is associated with low risk of drug dependence. Despite its poten
Externí odkaz:
https://doaj.org/article/cb33bcfa1c674c8684c73a0815c0c282
Autor:
Siyuan Shen, Yue Deng, Chenglong Shen, Haidi Chen, Lin Cheng, Chao Wu, Chang Zhao, Zhiqian Yang, Hanlin Hou, Kexin Wang, Zhenhua Shao, Cheng Deng, Feng Ye, Wei Yan
Publikováno v:
MedComm, Vol 5, Iss 7, Pp n/a-n/a (2024)
Abstract Neuropeptide Y (NPY), a 36‐amino‐acid peptide, functions as a neurotransmitter in both the central and peripheral nervous systems by activating the NPY receptor subfamily. Notably, NPY analogs display varying selectivity and exert divers
Externí odkaz:
https://doaj.org/article/115b96047dec47dbb7fdd3fbee90e1a6
Autor:
Lin Cheng, Fan Xia, Ziyan Li, Chenglong Shen, Zhiqian Yang, Hanlin Hou, Suyue Sun, Yuying Feng, Xihao Yong, Xiaowen Tian, Hongxi Qin, Wei Yan, Zhenhua Shao
Publikováno v:
Molecular Biomedicine, Vol 4, Iss 1, Pp 1-39 (2023)
Abstract G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide array of physiological processes and responses, such as sensory perception (e.g., vision, taste, and smell), immune response, hormone regulation, and neu
Externí odkaz:
https://doaj.org/article/9145c1751e7249539653cb0aa973510b
Autor:
Lin Cheng, Suyue Sun, Heli Wang, Chang Zhao, Xiaowen Tian, Ying Liu, Ping Fu, Zhenhua Shao, Renjie Chai, Wei Yan
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract Hydroxycarboxylic acid receptor 2 (HCAR2), a member of Class A G-protein-coupled receptor (GPCR) family, plays a pivotal role in anti-lipolytic and anti-inflammatory effects, establishing it as a significant therapeutic target for treating d
Externí odkaz:
https://doaj.org/article/dbeee4ccf3bc4a1db932d2ee444fbedc
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 2, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/926ca8d152f1496d87ab4b717b4dc2db
Autor:
Jie Zhao, Hong Fu, Jingjing Yu, Weiqi Hong, Xiaowen Tian, Jieyu Qi, Suyue Sun, Chang Zhao, Chao Wu, Zheng Xu, Lin Cheng, Renjie Chai, Wei Yan, Xiawei Wei, Zhenhua Shao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Somatostatin receptor 2 (SSTR2) represents a therapeutic target of neuroendocrine tumors. Here, authors report two structures of SSTR2 bound to peptide octreotide and small molecule paltusotine, revealing the basis subtype selectivity and signal bias
Externí odkaz:
https://doaj.org/article/19c0ed6851b54cc6b163ef852307c959
Autor:
Wei Yang, Bo Mu, Jing You, Chenyu Tian, Huachao Bin, Zhiqiang Xu, Liting Zhang, Ronggang Ma, Ming Wu, Guo Zhang, Chong Huang, Linli Li, Zhenhua Shao, Lunzhi Dai, Laurent Désaubry, Shengyong Yang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Ferroptosis is a promising therapeutic target for a variety of diseases, but a majority of known ferroptosis inhibitors belong to either antioxidants or iron chelators. Here, the authors discover a new non-classical small molecule inhibitor that is a
Externí odkaz:
https://doaj.org/article/5bae468ec3a34502ae52c86217dd6b9b
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
D1 dopamine receptor is an important drug target for treatment of hypertension and Parkinson’s disease. Here, authors report three cryo-EM structures of the D1R-Gs complex bound to three distinct D1R-selective drugs.
Externí odkaz:
https://doaj.org/article/5d48e2d6e9da4e2b90948778670506e9
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
G protein-coupled receptors (GPCRs), the largest family of transmembrane proteins, regulate a wide array of physiological processes in response to extracellular signals. Although these receptors have proven to be the most successful class of drug tar
Externí odkaz:
https://doaj.org/article/4a8ecb1d8a5b4f4e893ce1709dff94c6