Výsledky vyhledávání - "Zhenhong Guo"

Akademický článek

Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis via the inhibition of the SIRT3/SMCT1 pathway

Autor: Jinlan Xie, Feifei Zhong, Zhenhong Guo, Xinran Li, Jingyu Wang, Zhongai Gao, Baocheng Chang, Juhong Yang

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

ObjectiveTo investigate the effects and mechanism of hyperinsulinemia on the metabolic switch to β‐hydroxybutyrate (BHB) absorption and utilization under a starvation or hypoxic environment in proximal tubular epithelial cells.MethodsA high-fat di

Externí odkaz: https://doaj.org/article/a6a4c6dbb39d4f90a479b1e2bc58c9dd

Zobrazit plný text záznamu

Akademický článek

A phase I/II clinical trial on the efficacy and safety of NKT cells combined with gefitinib for advanced EGFR-mutated non-small-cell lung cancer

Autor: Wanjun Yu, Fei Ye, Xiao Yuan, Yali Ma, Chaoming Mao, Xiaoqin Li, Jian Li, Chunhua Dai, Fenhong Qian, Junrong Li, Xiujuan Fan, Yuepeng Zhou, Deqiang Wang, Zhenhong Guo, Huazhang An, Minghui Zhang, Deyu Chen, Sheng Xia

Publikováno v: BMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021)

Abstract Background Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, have achieved good efficacy in EGFR mutation-positive non-small-cell lung cancer (NSCLC) patients, but eventual drug resistance is inevita

Externí odkaz: https://doaj.org/article/4621a5a84ba44db285341456db9a0cac

Zobrazit plný text záznamu

Akademický článek

The therapeutic effects of bone marrow-derived mesenchymal stromal cells in the acute lung injury induced by sulfur mustard

Autor: Yongwei Feng, Qingqiang Xu, Yuyan Yang, Wenwen Shi, Wenqi Meng, Hao Zhang, Xiaowen He, Mingxue Sun, Yongchun Chen, Jie Zhao, Zhenhong Guo, Kai Xiao

Publikováno v: Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-17 (2019)

Abstract Background Sulfur mustard (SM) is a notorious chemical warfare agent that can cause severe acute lung injury (ALI), in addition to other lesions. Currently, effective medical countermeasures for SM are lacking. Bone marrow-derived mesenchyma

Externí odkaz: https://doaj.org/article/b0fdf17b4f1841af8b269400e6d1a10d

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Pathological Hyperinsulinemia and Hyperglycemia in the Impaired Glucose Tolerance Stage Mediate Endothelial Dysfunction Through miR-21, PTEN/AKT/eNOS, and MARK/ET-1 Pathways

Autor: Ran Liu, Shilin Guan, Zhongai Gao, Jingyu Wang, Jie Xu, Zhaohu Hao, Yi Zhang, Shaohua Yang, Zhenhong Guo, Juhong Yang, Hailin Shao, Baocheng Chang

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

BackgroundImpaired glucose tolerance (IGT) is an important prediabetic stage characterized by elevated concentrations of glucose and insulin in the blood. The pathological hyperglycemia and hyperinsulinemia in IGT may regulate the expression of micro

Externí odkaz: https://doaj.org/article/5021d3828fa84cfba64153ad4c24c70e

Zobrazit plný text záznamu

Akademický článek

Retinal Neuropathy in IGT Stage of OLETF Rats: Another Characteristic Change of Diabetic Retinopathy

Autor: Zhenhong Guo, Xiaoyue Sun, Juhong Yang, Jinlan Xie, Feifei Zhong, Xinran Li, Yi Zhang, Fei Han, Xiaoyun Yang, Shaohua Yang, Wei Zhou, Baocheng Chang

Publikováno v: Journal of Diabetes Research, Vol 2021 (2021)

Aims. We investigated the changes of retinal structure in normal glucose tolerance (NGT), impaired glucose tolerance (IGT), diabetes mellitus (DM), and diabetic kidney disease (DKD) stages in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Methods. W

Externí odkaz: https://doaj.org/article/bdc0e57338aa43449772c9301f78d26f

Zobrazit plný text záznamu

Akademický článek

Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway

Autor: Yi Zhang, Shaohua Yang, Xiao Cui, Juhong Yang, Miaoyan Zheng, Junya Jia, Fei Han, Xiaoyun Yang, Jingyu Wang, Zhenhong Guo, Bai Chang, Baocheng Chang

Publikováno v: Journal of Diabetes Research, Vol 2019 (2019)

Aims. We investigated the changes of renal structure and its function in normal glucose tolerance (NGT), impaired glucose tolerance (IGT), diabetes mellitus (DM), and diabetic kidney disease (DKD) stages in OLETF rats and explored the role of the INS

Externí odkaz: https://doaj.org/article/9edb3ab735ee43c88f3f9c79b07b1e6b

Zobrazit plný text záznamu

Plný text ve formátu HTML