A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

Autor: Grace Q. Gong, Benoit Bilanges, Ben Allsop, Glenn R. Masson, Victoria Roberton, Trevor Askwith, Sally Oxenford, Ralitsa R. Madsen, Sarah E. Conduit, Dom Bellini, Martina Fitzek, Matt Collier, Osman Najam, Zhenhe He, Ben Wahab, Stephen H. McLaughlin, A. W. Edith Chan, Isabella Feierberg, Andrew Madin, Daniele Morelli, Amandeep Bhamra, Vanesa Vinciauskaite, Karen E. Anderson, Silvia Surinova, Nikos Pinotsis, Elena Lopez-Guadamillas, Matthew Wilcox, Alice Hooper, Chandni Patel, Maria A. Whitehead, Tom D. Bunney, Len R. Stephens, Phillip T. Hawkins, Matilda Katan, Derek M. Yellon, Sean M. Davidson, David M. Smith, James B. Phillips, Richard Angell, Roger L. Williams, Bart Vanhaesebroeck

Publikováno v: Nature. 618:159-168

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8f8e36156cc591a3aec34b2fffc9688
https://doi.org/10.1038/s41586-023-05972-2

Exosomes from neuronal stem cells may protect the heart from ischaemia/reperfusion injury via JAK1/2 and gp130

Autor: Vladimir Vinokur, Derek M. Yellon, Miroslava Katsur, Sean M. Davidson, Zhenhe He, Randolph Corteling

Publikováno v: Journal of Cellular and Molecular Medicine

Myocardial infarction requires urgent reperfusion to salvage viable heart tissue. However, reperfusion increases infarct size further by promoting mitochondrial damage in cardiomyocytes. Exosomes from a wide range of different cell sources have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31091e6669b25c5ceeae3e55928dff9c
https://pubmed.ncbi.nlm.nih.gov/33797200

Small extracellular vesicles secreted from human amniotic fluid mesenchymal stromal cells possess cardioprotective and promigratory potential

Autor: Harvey E. Johnston, Derek M. Yellon, Pascale V. Guillot, Kaloyan Takov, John F. Timms, Zhenhe He, Sean M. Davidson

Publikováno v: Basic Research in Cardiology

Mesenchymal stromal cells (MSCs) exhibit antiapoptotic and proangiogenic functions in models of myocardial infarction which may be mediated by secreted small extracellular vesicles (sEVs). However, MSCs have frequently been harvested from aged or dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8fbe3cedeb64600f8cc301ec16b467
http://europepmc.org/articles/PMC7060967

Myocardial Infarct Size Reduction Provided by Local and Remote Ischaemic Preconditioning: References Values from the Hatter Cardiovascular Institute

Autor: Zhenhe He, Derek M. Yellon, Xavier Rossello

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Cardiovascular Drugs and Therapy

To accurately estimate the effect size of both local or classic ischaemic preconditioning (IPC) and remote ischaemic preconditioning (RIPC) using a pooling data set of 91 animals. We combined all the available mouse data collected from our Institute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec254d5950eace2a1a7bb2a48d003d5
https://hdl.handle.net/20.500.12105/6679

Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood

Autor: David J. Hodson, Patrice Mollard, Claudia Sánchez-Cárdenas, Marie Schaeffer, Anne-Cécile Meunier, Danielle Carmignac, Xavier Bonnefont, Iain C. A. F. Robinson, Pierre Fontanaud, Zhenhe He, Paul Le Tissier, Elodie Gavois, Nathalie Coutry, Laurie-Anne Gouty-Colomer, François Molino, Chrystel Lafont

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2010, 107 (50), pp.21878-21883. ⟨10.1073/pnas.1010849107⟩
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (50), pp.21878-21883. ⟨10.1073/pnas.1010849107⟩

There are well-recognized sex differences in many pituitary endocrine axes, usually thought to be generated by gonadal steroid imprinting of the neuroendocrine hypothalamus. However, the recognition that growth hormone (GH) cells are arranged in func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceaba955ee5ea9ad36e7e615785c2118
https://doi.org/10.1073/pnas.1010849107