Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Zhengze Lu"'
Enhanced stability and efficacy of GEM-TOS prodrug by co-assembly with antimetastatic shell LMWH-TOS
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 10, Pp 1977-1988 (2020)
Chemotherapy agents have been widely used for cancer treatment, while the insolubility, instability and toxicity seriously restrict their efficacy. Thus, prodrug strategy was devised. Since some prodrugs are still with poor solubility or stability, a
Externí odkaz:
https://doaj.org/article/a99e68e74880486fbf4a37af9dadae31
Autor:
Chunyu Xia, Wenjing Bai, Tao Deng, Ting Li, Ling Zhang, Zhengze lu, Zhirong Zhang, Man Li, Qin He
Publikováno v:
Acta Biomaterialia. 158:708-724
Publikováno v:
Nanoscale. 14:17315-17330
Myeloid-derived suppressor cells (MDSCs) are notorious for their pathological characteristics of immunosuppression and their promoting effect on cancers. They can induce the formation of pre-metastatic niche (PMN) characterized by inflammation, immun
Autor:
Hanbing Xie, Yue Qiu, Xuhui Wang, Jianping Li, Chaoqun Xu, Zhengze Lu, Man Li, Qin He, Yashi Wang, Lifeng Tian, Rong Guo, Qianwen Yu
Publikováno v:
Acta Biomaterialia. 134:546-558
The dilemma of tumor accumulation and deep penetration has always been a barrier in antitumor therapy. Stimuli-responsive size changeable drug delivery systems provide possible solutions. Nevertheless, the low size-shrinkage efficiency limited the an
Autor:
Wei Zhao, Shuya Zang, Yang Long, Man Li, Qinglin Sheng, Zhengze Lu, Ting Li, Rong Guo, Jiaxin Li, Qin He, Zhirong Zhang
Publikováno v:
ACS Applied Materials & Interfaces. 13:25701-25714
It has been a great challenge to simultaneously inhibit the outgrowth of both the primary tumor and metastasis in metastatic cancer treatment. Substantial studies have evidenced that the interaction of platelets and cancer cells supports tumor metast
Publikováno v:
International journal of pharmaceutics. 628
The progression of breast cancer can stimulate the production of myeloid-derived suppressor cells (MDSCs). These cells with significant immunosuppressive activity play a key role in promoting the formation of pulmonary inflammatory and immunosuppress
Autor:
Zhirong Zhang, Yang Long, Qin He, Xiaoxiao Chen, Zhengze Lu, Xuhui Wang, Sheng Yin, Yue Qiu, Man Li, Dandan Wan, Jingdong Rao, Qianwen Yu
Publikováno v:
Journal of Controlled Release. 321:497-508
Non-viral gene delivery systems have proven to be a promising approach in the treatment of brain metastatic cancers but facing delivery difficulties. Due to the existence of blood-brain barrier, non-viral gene carriers must pass through brain capilla
Publikováno v:
Nano Letters. 20:2219-2229
Distal metastases of tumors result from the interaction between "seeds" (circulating tumor cells, CTCs) and "soil" (premetastatic niche, PMN). Various strategies focus on CTC inhibition, but only a few strategies inhibit PMN formation. The main predi
Enhanced stability and efficacy of GEM-TOS prodrug by co-assembly with antimetastatic shell LMWH-TOS
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 10, Pp 1977-1988 (2020)
Acta Pharmaceutica Sinica B, Vol 10, Iss 10, Pp 1977-1988 (2020)
Chemotherapy agents have been widely used for cancer treatment, while the insolubility, instability and toxicity seriously restrict their efficacy. Thus, prodrug strategy was devised. Since some prodrugs are still with poor solubility or stability, a
Autor:
Zhengze Lu, Yang Long, Jiaxin Li, Kebai Ren, Wei Zhao, Xuhui Wang, Chunyu Xia, Yashi Wang, Man Li, Zhirong Zhang, Qin He
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 338
Inflammatory feed-forward loops including the steps of “inflammatory cell recruitment”, “inflammatory signaling pathway activation” and “inflammatory factor production” are essential in the development of breast cancer and its metastasis.