Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Zhengyuan Pang"'
Autor:
Zhengyuan Pang, Li Ye
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101778- (2022)
Summary: Here, we provide a protocol to visualize on-target specific drug binding in mammalian tissue with cellular resolution. By combining tissue clearing and click chemistry, this protocol allows fluorescence tagging of covalent drug binding in si
Externí odkaz:
https://doaj.org/article/6a02e22ca28a4d52ae24e0f9b2cf2bd8
Autor:
Zhengyuan Pang, Li Ye
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 8, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/c678aa8bf0e446fea582e7e6e43be79e
Autor:
Victoria Nudell, Yu Wang, Zhengyuan Pang, Neeraj K. Lal, Min Huang, Namir Shaabani, Wesam Kanim, John Teijaro, Anton Maximov, Li Ye
Publikováno v:
Nat Methods
The recent development of solvent- and polymer-based brain clearing techniques has greatly advanced our ability to visualize the mammalian nervous system in 3D. However, it remains challenging to image the mammalian body en bloc as existing methods c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0945b05fd47a9d51cf58e243c80db8a4
https://doi.org/10.1038/s41592-022-01427-0
https://doi.org/10.1038/s41592-022-01427-0
Autor:
Neeraj K. Lal, Phuong Le, Samarth Aggarwal, Alan Zhang, Kristina Wang, Tianbo Qi, Zhengyuan Pang, Dong Yang, Victoria Nudell, Gene W. Yeo, Alexander S. Banks, Li Ye
Publikováno v:
bioRxiv
SummaryMaintaining body temperature is calorically expensive for endothermic animals. Mammals eat more in the cold to compensate for energy expenditure, but the neural mechanism underlying this coupling is not well understood. Through behavioral and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994aa34124e27c7cb788405308a21bd0
https://europepmc.org/articles/PMC10055253/
https://europepmc.org/articles/PMC10055253/
Publikováno v:
2022 IEEE 22nd International Conference on Software Quality, Reliability and Security (QRS).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::736596091a3ad46f1f377464f55262bf
https://doi.org/10.1109/qrs57517.2022.00061
https://doi.org/10.1109/qrs57517.2022.00061
Publikováno v:
2022 7th IEEE International Conference on Data Science in Cyberspace (DSC).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31201cf8dac3c90aa33c91e911b91996
https://doi.org/10.1109/dsc55868.2022.00038
https://doi.org/10.1109/dsc55868.2022.00038
Publikováno v:
2022 7th IEEE International Conference on Data Science in Cyberspace (DSC).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ee5987305548b0ead455e725df768b4
https://doi.org/10.1109/dsc55868.2022.00017
https://doi.org/10.1109/dsc55868.2022.00017
Publikováno v:
ACS Chemical Biology. 14:2557-2563
Abscisic acid (ABA) is a key phytohormone with diverse functions in plants, and its signal transduction is mainly mediated by ABA receptors termed PYR/PYL/RCARs (hereafter referred to as PYLs) through the PYLs-PP2Cs-SnRK2s regulatory systems. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff09ccd471281793a78f194a3d6970d0
https://doi.org/10.1021/acschembio.9b00806
https://doi.org/10.1021/acschembio.9b00806
Autor:
Zhengyuan Pang, Michael A. Schafroth, Daisuke Ogasawara, Yu Wang, Victoria Nudell, Neeraj K. Lal, Dong Yang, Kristina Wang, Dylan M. Herbst, Jacquelyn Ha, Carlos Guijas, Jacqueline L. Blankman, Benjamin F. Cravatt, Li Ye
Publikováno v:
Cell. 185(10)
The lack of tools to observe drug-target interactions at cellular resolution in intact tissue has been a major barrier to understanding in vivo drug actions. Here, we develop clearing-assisted tissue click chemistry (CATCH) to optically image covalen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0e8a387c2417511df2325927e80ec9
https://pubmed.ncbi.nlm.nih.gov/36030504
https://pubmed.ncbi.nlm.nih.gov/36030504
Publikováno v:
Organic & Biomolecular Chemistry. 17:6369-6373
Protein-protein interactions (PPIs) are indispensable in almost all cellular processes. Probing of complex PPIs provides new insights into the biological system of interest and paves the way for the development of therapeutics. Herein, we report a st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886dd05f2c0cd4f33e9084bc5d337a76
https://doi.org/10.1039/c9ob01048c
https://doi.org/10.1039/c9ob01048c