Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Zhengyuan Cheng"'
Autor:
Yu Zhang, Chuanbing Shi, Yiqiong Yang, Xiuxiu Hu, Haifeng Ni, Li Li, Zhengyuan Cheng, Jing Huang, Pingsheng Chen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Renal interstitial fibrosis (RIF) is a key feature of progressive chronic kidney disease (CKD), characterized by tubular epithelial cell (TEC) hypoxia and peritubular capillary (PTC) rarefaction. However, the mechanisms underlying these proc
Externí odkaz:
https://doaj.org/article/54a1be1096ff45308fdc26eb99e04ae5
Autor:
Jing Liu, Wencai Li, Manoj H. Limbu, Yiping Li, Zhi Wang, Zhengyuan Cheng, Xiaoyi Zhang, Pingsheng Chen
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Background and Aim: To investigate whether double-knockdown of PHD1 and Keap1 in mice could enhance the resolution of carbon tetrachloride (CCl4)-induced liver fibrosis.Methods: The liver fibrosis model of mice was established by intraperitoneal inje
Externí odkaz:
https://doaj.org/article/6a3d269bef9f42f99a6b717ca193229f
Autor:
Jing Liu, Yiping Li, Lei Liu, Zhi Wang, Chuanbing Shi, Zhengyuan Cheng, Xiaoyi Zhang, Fengan Ding, Ping Sheng Chen
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Background and Aims: Hypoxia and oxidative stress contribute toward liver fibrosis. In this experiment, we used small hairpin RNA (shRNA) to interfere with the intracellular oxygen sensor—prolyl hydroxylase 1 (PHD1) and the intracellular oxidative
Externí odkaz:
https://doaj.org/article/a4a2e5e3c3f14c77943dfac2978b9804
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 2, p 581 (2018)
The aggravation of renal interstitial fibrosis in the advanced-stage of chronic kidney disease is related to decreased matrix metalloproteinase-2 (MMP-2) activity, which is induced by hypoxia in the kidney; however, the specific mechanism remains unc
Externí odkaz:
https://doaj.org/article/3c032dd5e1974e7293edf8e0bfd04fb5
Autor:
Zhengyuan Cheng, Manoj Hang Limbu, Zhi Wang, Jing Liu, Lei Liu, Xiaoyi Zhang, Pingsheng Chen, Bicheng Liu
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 4, p 776 (2017)
Gelatinases are members of the matrix metalloproteinase (MMPs) family; they play an important role in the degradation of the extracellular matrix (ECM). This effect is also crucial in the development and progression of chronic kidney disease (CKD). I
Externí odkaz:
https://doaj.org/article/2ed3d80364944c4c86d642fb7b305d34
Publikováno v:
Open life sciences. 17(1)
Matrix metalloproteinase-2 (MMP-2) and cluster of differentiation 147 (CD147) both play important roles in the development of kidney fibrosis, and CD147 can induce the production and activation of MMP-2. In the early stage of kidney fibrosis, MMP-2 p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a68e5e5b2bd25193481156e4d9be0b1
https://pubmed.ncbi.nlm.nih.gov/36185410
https://pubmed.ncbi.nlm.nih.gov/36185410
Autor:
Ji Xuan, Ya Yang, Wang Fangyu, Feng Qin, Mei Shao, Zhengyuan Cheng, Qiu Yuping, Dongmei Zhu, Qi Zhai
Publikováno v:
Cell Cycle
Crocin is the main monomer of saffron, which is a momentous component of traditional Chinese medicine Lang Qing A Ta. Here, we tried to probe into the role of crocin in liver fibrosis. Hematoxylin-eosin staining and Sirius Red staining were used to o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ef34db6440ed7a48ba13564db70c27
https://pubmed.ncbi.nlm.nih.gov/33295246
https://pubmed.ncbi.nlm.nih.gov/33295246
Autor:
Bi-Cheng Liu, Pingsheng Chen, Yingying Cai, Manoj Hang Limbu, Zhi Wang, Qing Xu, Fengan Ding, Zhengyuan Cheng, Yiping Li, Lei Liu, Yiqiong Yang
Publikováno v:
Experimental Cell Research. 370:198-207
Most patients with chronic kidney disease (CKD) present with proteinuria and extracellular matrix (ECM) deposition in the interstitium. Matrix metalloproteinase-2 (MMP-2) is important for maintaining ECM metabolism and it affects the formation and de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3c74a3cc4f96a2d909f28e1c4250e4
https://doi.org/10.1016/j.yexcr.2018.06.019
https://doi.org/10.1016/j.yexcr.2018.06.019
Autor:
Chuanbing Shi, Lei Liu, Sijie Chen, Zhengyuan Cheng, Zhi Wang, Jing Liu, Fengan Ding, Pingsheng Chen, Xiaoyi Zhang
Publikováno v:
Cell Biology International. 41:922-927
Renal cell carcinoma (RCC) is characterized by excessive angiogenesis, while chronic kidney disease (CKD) suffers from the opposite problem-failure of reparative angiogenesis. It can be due to their different responses to hypoxic environment. But the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42c33efe285dab785f9bc8be772ee129
https://doi.org/10.1002/cbin.10801
https://doi.org/10.1002/cbin.10801
Autor:
Zhengyuan Cheng, Fengan Ding, Jun Dou, Pingsheng Chen, Lei Liu, Jing Liu, Yiping Li, Xiaoyi Zhang, Wenmin Yu, Zhi Wang
Publikováno v:
International Journal of Molecular Medicine. 38:894-902
Chronic hypoxia often occurs among patients with chronic kidney disease (CKD). Renal proximal tubular cells may be the primary target of a hypoxic insult. However, the underlying transcriptional mechanisms remain undefined. In this study, we revealed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d43c6e0ed258aad2a99ee80849d4ff
https://doi.org/10.3892/ijmm.2016.2677
https://doi.org/10.3892/ijmm.2016.2677