Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Zhengyu Yuan"'
Autor:
Jinqian, Liu, Wen, Wang, Changqing, Wang, Li, Zhang, Xueliang, Zhang, Shicong, Liu, Yunhua, Xu, Hailin, Wang, Qing, Dai, Chun, Liu, Xinghai, Wang, Zhengyu, Yuan, Mikhail F, Gordeev
Publikováno v:
ACS medicinal chemistry letters. 13(7)
New oral antibiotic contezolid (CZD) is effective against Gram-positive infections but unsuitable for intravenous (IV) administration due to its modest solubility. To address the medical need for an IV form of CZD, its isoxazol-3-yl phosphoramidate d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c562c941d781c7251a4f6489b80d485
https://pubmed.ncbi.nlm.nih.gov/35859881
https://pubmed.ncbi.nlm.nih.gov/35859881
Autor:
Jinqian Liu, Wen Wang, Changqing Wang, Li Zhang, Xueliang Zhang, Shicong Liu, Yunhua Xu, Hailin Wang, Qing Dai, Chun Liu, Xinghai Wang, Zhengyu Yuan, Mikhail F. Gordeev
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1030-1035
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a0a2dfad2eb5c880c6794214816ad22
https://doi.org/10.1021/acsmedchemlett.2c00191
https://doi.org/10.1021/acsmedchemlett.2c00191
Publikováno v:
Computers, Materials & Continua. 73:563-576
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d366571b1ab747a6520178fb1097d51
https://doi.org/10.32604/cmc.2022.027008
https://doi.org/10.32604/cmc.2022.027008
Autor:
Hong Yuan, Hailan Wu, Yingyuan Zhang, Haihui Huang, Yi Li, Junzhen Wu, Guoying Cao, Jicheng Yu, Beining Guo, Jufang Wu, Zhengyu Yuan, Yuancheng Chen, Wanqiu Yang, Xiaojie Wu, Jing Zhang
Publikováno v:
Antimicrob Agents Chemother
This study aimed to build a population pharmacokinetic (PopPK) model for contezolid tablet (MRX-I) in healthy subjects and adults with complicated skin and soft-tissue infections (cSSTIs) to further evaluate the efficacy and safety of contezolid and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f369953414453acc44532d00e19db376
https://doi.org/10.1128/aac.02430-21
https://doi.org/10.1128/aac.02430-21
Publikováno v:
Economic Modelling. 120:106184
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7579eeebea07b943b8d6c8d89ad444cd
https://doi.org/10.1016/j.econmod.2022.106184
https://doi.org/10.1016/j.econmod.2022.106184
Publikováno v:
Journal of Antimicrobial Chemotherapy. 77:3210-3211
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53e6dd6e0b7f44dd64d8cb165ac6666
https://doi.org/10.1093/jac/dkac282
https://doi.org/10.1093/jac/dkac282
Publikováno v:
The Journal of antimicrobial chemotherapy. 77(6)
Objectives Contezolid is a novel oxazolidinone antibacterial agent for managing infections caused by aerobic and anaerobic Gram-positive bacteria including methicillin-resistant strains. A Phase III, multicentre, randomized, double-blind, active-cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f34eae95050ff0814cdf69911c7513f
https://pubmed.ncbi.nlm.nih.gov/35972415
https://pubmed.ncbi.nlm.nih.gov/35972415
Autor:
Liang Li, Mikhail Fedorovich Gordeev, Zhengyu Yuan, Jinqian Liu, Hong Yuan, Chen Li, Dafang Zhong, Jian Meng, Xiaoyan Chen, Jialan Zhou, Cen Xie
Publikováno v:
Drug Metabolism and Disposition. 43:646-659
MRX-I is an analog of linezolid containing a 2,3-dihydropyridin-4-one (DHPO) ring rather than a morpholine ring. Our objectives were to characterize the major metabolic pathways of MRX-I in humans and clarify the mechanism underlying the oxidative ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889acef6dbd1b3c43e8ba0a44166b4e9
https://doi.org/10.1124/dmd.114.061747
https://doi.org/10.1124/dmd.114.061747
Autor:
Mikhail F. Gordeev, Qinglan Guo, Zhengyu Yuan, Baixue Wu, Shicong Liu, Hailin Wang, Wen Wang, Minggui Wang, Xiaogang Xu, Yunhua Xu, Yanqin Huang
Publikováno v:
International Journal of Antimicrobial Agents. 43:418-422
MRX-I is a new oxazolidinone antimicrobial under development. In this study, the potential for development of resistance to MRX-I in Staphylococcus aureus was investigated and key mutations were characterised. Determination of spontaneous resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c19913fe6f372bd2959e43f35e53ed
https://doi.org/10.1016/j.ijantimicag.2014.02.008
https://doi.org/10.1016/j.ijantimicag.2014.02.008
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:1656-1663
Peptide deformylase (PDF) is an essential enzyme in both gram-negative and gram-positive bacteria. It hydrolyzes formylated N-terminal peptides to generate free N-terminal peptides during the process of protein maturation. Inhibition of this enzyme r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5f463111c23b14f90cfb90fb82ce51
https://doi.org/10.1128/aac.50.5.1656-1663.2006
https://doi.org/10.1128/aac.50.5.1656-1663.2006