Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Zhengxi Dai"'
Autor:
Gang Xin, David M. Schauder, Begoña Lainez, Jason S. Weinstein, Zhengxi Dai, Yuhong Chen, Enric Esplugues, Renren Wen, Demin Wang, Ian A. Parish, Allan J. Zajac, Joe Craft, Weiguo Cui
Publikováno v:
Cell Reports, Vol 13, Iss 6, Pp 1118-1124 (2015)
Control of chronic viral infections by CD8 T cells is critically dependent on CD4 help. In particular, helper-derived IL-21 plays a key role in sustaining the CD8 T cell response; however, the molecular pathways by which IL-21 sustains CD8 T cell imm
Externí odkaz:
https://doaj.org/article/031268850da540dc86f2ac3d68847235
Autor:
Guizhong Liu, Zhengxi Dai, Jiagui Qu, Jianfeng Shi, Qi Zhao, Bin Cai, Aaron N. Nguyen, Songmao Zheng, Jiangchun Xu, Yan Li, Felix Du, Peter Luo
Publikováno v:
Cancer Research. 82:2888-2888
Targeting CD28 for systemic T cell activation caused severe cytokine storm and multiorgan failure in an anti-CD28 antibody TGN1412 phase 1 trial. However, tumor specific CD28 targeting in a tumor associated antigen (TAA)×CD28 bispecific format, simi
Autor:
Guizhong Liu, Yan Li, Zhengxi Dai, Jiagui Qu, Jianfeng Shi, Qi Zhao, Linhai Qu, Aaron N. Nguyen, Songmao Zheng, Jiangchun Xu, Felix Du, Peter Luo
Publikováno v:
Cancer Research. 82:2869-2869
Bispecific T-cell engagers (TCEs) have shown therapeutic promise in treating hematologic cancers. However, their utility in treating solid tumors has yet to be effectively demonstrated due to on-target off-tumor toxicity and systemic cytokine release
Autor:
Guizhong Liu, Zhengxi Dai, Jiagui Qu, Jianfeng Shi, Qi Zhao, Linhai Qu, Yan Li, Songmao Zheng, Jiangchun Xu, Felix Du, Peter Luo
Publikováno v:
Cancer Research. 82:2868-2868
Targeting CD137 by agonistic antibodies faces various challenges in the clinic. Utomilumab appears safe but has modest efficacy, while urelumab is more efficacious but causes severe dose-dependent liver toxicity. To unlock the full potential of CD137
Autor:
Zhengxi Dai, Gang Xin, Allan J. Zajac, Weiguo Cui, Renren Wen, Joe Craft, David M. Schauder, Ian A. Parish, Begoña Lainez, Enric Esplugues, Demin Wang, Yuhong Chen, Jason S. Weinstein
Publikováno v:
Cell Reports, Vol 13, Iss 6, Pp 1118-1124 (2015)
SummaryControl of chronic viral infections by CD8 T cells is critically dependent on CD4 help. In particular, helper-derived IL-21 plays a key role in sustaining the CD8 T cell response; however, the molecular pathways by which IL-21 sustains CD8 T c
Publikováno v:
Oncoimmunology
The CD1d-dependent presentation of lipid antigens to natural killer T (NKT) cells is an integral part of the innate immune system. However, the development of anticancer therapies based on NKT-cell agonists has had limited success so far. Humanizing
Publikováno v:
OncoImmunology; Aug2013, Vol. 2 Issue 8, p1-3, 3p