Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Zhengwei Hu"'
Autor:
Mengjie Li, Xiaoyan Hao, Zhengwei Hu, Jie Tian, Jingjing Shi, Dongrui Ma, Mengnan Guo, Shuangjie Li, Chunyan Zuo, Yuanyuan Liang, Mibo Tang, Chengyuan Mao, Yuming Xu, Changhe Shi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Alzheimer’s disease (AD) is the most common cause of dementia, characterized by memory loss, cognitive decline, personality changes, and various neurological symptoms. The role of blood–brain barrier (BBB) injury, extracellular matrix (E
Externí odkaz:
https://doaj.org/article/7856c0d91cb142a6a5e0952b06e95cee
Autor:
Changhe Shi, Dongrui Ma, Mengjie Li, Zhiyun Wang, Chenwei Hao, Yuanyuan Liang, Yanmei Feng, Zhengwei Hu, Xiaoyan Hao, Mengnan Guo, Shuangjie Li, Chunyan Zuo, Yuemeng Sun, Mibo Tang, Chengyuan Mao, Chan Zhang, Yuming Xu, Shilei Sun
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-8 (2024)
Abstract There is considerable uncertainty regarding the associations between various risk factors and Parkinson’s Disease (PD). This study systematically screened and validated a wide range of potential PD risk factors from 502,364 participants in
Externí odkaz:
https://doaj.org/article/a1f6b71a19ab49d387414d6d6ac8fe4c
Autor:
Chun-yan Zuo, Zhengwei Hu, Xiao-yan Hao, Meng-jie Li, Jing-jing Shi, Meng-nan Guo, Dong-rui Ma, Shuang-jie Li, Yuan-yuan Liang, Chan Zhang, Cheng-yuan Mao, Yuming Xu, Chang-he Shi
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionAlzheimer’s disease (AD) is the most widespread neurodegenerative disease in the world. Previous studies have shown that peripheral immune dysregulation plays a paramount role in AD, but whether there is a protective causal relationship
Externí odkaz:
https://doaj.org/article/0871f6887b114830bfddf21233ed817a
Autor:
Zhengwei Hu, Jing Yang, Shuo Zhang, Mengjie Li, Chunyan Zuo, Chengyuan Mao, Zhongxian Zhang, Mibo Tang, Changhe Shi, Yuming Xu
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 1, Pp 253-264 (2025)
The E3 ubiquitin ligase, carboxyl terminus of heat shock protein 70 (Hsp70) interacting protein (CHIP), also functions as a co-chaperone and plays a crucial role in the protein quality control system. In this study, we aimed to investigate the neurop
Externí odkaz:
https://doaj.org/article/686ebbcbad92423d8724b6827a8a80c6
Autor:
Yun Su, Huimin Zheng, Changhe Shi, Xinwei Li, Shuyu Zhang, Guangyu Guo, Wenkai Yu, Shuo Zhang, Zhengwei Hu, Jing Yang, Zongping Xia, Chengyuan Mao, Yuming Xu
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-12 (2023)
Abstract The meninges, membranes surrounding the central nervous system (CNS) boundary, harbor a diverse array of immunocompetent immune cells, and therefore, serve as an immunologically active site. Meningeal immunity has emerged as a key factor in
Externí odkaz:
https://doaj.org/article/f846b41ddb7541ed998d6f1e7db53529
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionThe peripheral immune system changes in amyotrophic lateral sclerosis (ALS), but the causal relationship between the two is still controversial.MethodsIn this study, we aimed to estimate the causal relationship between peripheral immune m
Externí odkaz:
https://doaj.org/article/d8ee3f24bdca4e3593915b2bb838233b
Autor:
Zhengwei Hu, Qiri Huang, Chunchen Liu, Ao Song, Lin Shao, Yuanqing Bai, Zhicheng Hu, Kai Zhang, Fei Huang, Yong Cao
Publikováno v:
Organic Materials, Vol 4, Iss 02, Pp 18-27 (2022)
Abstract A donor–acceptor (D-A) conjugated polymer PBTFO-T-1 consisting of 2,1,3-benzothiadiazole (BT) as A unit and thiophene (T) as D unit was facilely obtained by a straightforward three-step reaction. The BT unit is attached with a fluorine at
Externí odkaz:
https://doaj.org/article/f5e05667d55f4e748f0b26201141e366
Autor:
Mengjie Li, Fen Liu, Xiaoyan Hao, Yu Fan, Jiadi Li, Zhengwei Hu, Jingjing Shi, Liyuan Fan, Shuo Zhang, Dongrui Ma, Mengnan Guo, Yuming Xu, Changhe Shi
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Spinocerebellar ataxia 19/22 (SCA19/22) is a rare neurodegenerative disorder caused by mutations of the KCND3 gene, which encodes the Kv4. 3 protein. Currently, only 22 KCND3 single-nucleotide mutation sites of SCA19/22 have been reported worldwide,
Externí odkaz:
https://doaj.org/article/f185e50cbd9f4d29aff921d16b8e2b27
Autor:
Shaohua Li, Yunchao Wang, Huifang Sun, Zhuoya Wang, Qi Zhang, Yanlin Wang, Jing Yang, Changhe Shi, Yanpeng Yuan, Hao Wang, Anran Wang, Zhengwei Hu, Zhuo Li, Yuming Xu
Publikováno v:
Stem Cell Research, Vol 59, Iss , Pp 102663- (2022)
L1 cell adhesion molecule (L1CAM) is essential in various processes of neurodevelopment, including neuron migration, axon guidance, and synaptogenesis. Hundreds of L1CAM mutations have been implicated in neurodevelopmental defects, whereas the precis
Externí odkaz:
https://doaj.org/article/3157c71e7ba74b7aa8a511bcd532eaa7
Autor:
Fen Liu, Yu Fan, Liyuan Fan, Mengjie Li, Qimeng Zhang, Chengyuan Mao, Jun Wu, Shuo Zhang, Zhengwei Hu, Changhe Shi, Yuming Xu
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102320- (2021)
Spinocerebellar ataxia type 19 (SCA19) is an extremely rare autosomal dominant cerebellar ataxia hereditary that caused by the KCND3 gene mutation. And has a complex pathogenesis. At present, its pathogenesis is still unclear, and there is no effecti
Externí odkaz:
https://doaj.org/article/99c0587108164065981e02d6b71effdf