Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Zhengshan Hu"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Cyclic nucleotide-gated (CNG) channels transduce chemical signals into electrical signals in sensory receptors and neurons. They are activated by cGMP or cAMP, which bind to the cyclic nucleotide-binding domain (CNBD) to open a gate located
Externí odkaz:
https://doaj.org/article/8e94c7d680354065975d5e2d178f317e
Autor:
Zhengshan Hu, Jian Yang
Publikováno v:
Channels, Vol 17, Iss 1 (2023)
ABSTRACTRecent years have seen an outpouring of atomic or near atomic resolution structures of cyclic nucleotide-gated (CNG) channels, captured in closed, transition, pre-open, partially open, and fully open states. These structures provide unprecede
Externí odkaz:
https://doaj.org/article/480c1964004544d8a1798beb66b11daf
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
The R410W mutation in the cone photoreceptor CNG channel, linked to achromatopsia and assumed to be a loss-of-function variant, causes the channel to open spontaneously as revealed by cryo-EM, electrophysiology and calcium imaging, and is cytotoxic.
Externí odkaz:
https://doaj.org/article/20c0ba6213e24403bb1dd50ff498fe0c
Autor:
Ziao Fu, Minghui Li, Guohui Li, Zhenning Ren, Joachim Frank, Deyuan Su, Yuebin Zhang, Shufang Li, Huan Li, Jian Yang, Zhengshan Hu, Ming Zhou, Xiangdong Zheng, Xueming Li, Yaping Pan, Robert A. Grassucci
Publikováno v:
Nature structural & molecular biology
Cyclic nucleotide–gated (CNG) channels convert cyclic nucleotide (CN) binding and unbinding into electrical signals in sensory receptors and neurons. The molecular conformational changes underpinning ligand activation are largely undefined. We repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85efa0e78ab3835d51aca28ae25b6434
https://doi.org/10.1038/s41594-020-0433-5
https://doi.org/10.1038/s41594-020-0433-5
Publikováno v:
Nat Struct Mol Biol
Cyclic nucleotide-gated (CNG) channels transduce light-induced chemical signals into electrical signals in retinal cone and rod photoreceptors. Structures of native CNG channels, which are heterotetramers formed by CNGA and CNGB subunits, have not be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a9d6cff31dd0b33011e9c95c132c1c
https://europepmc.org/articles/PMC8776609/
https://europepmc.org/articles/PMC8776609/
Publikováno v:
Communications biology. 5(1)
Numerous missense mutations in cyclic nucleotide-gated (CNG) channels cause achromatopsia and retinitis pigmentosa, but the underlying pathogenic mechanisms are often unclear. We investigated the structural basis and molecular/cellular effects of R41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f34bcae831533bfd6639939b401c0f7
https://pubmed.ncbi.nlm.nih.gov/35233102
https://pubmed.ncbi.nlm.nih.gov/35233102
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1489
Two developments have greatly facilitated the construction of CCN mutant mouse strains. The first is the availability of modified embryonic stem (ES) cells and mice developed through several large-scale government-sponsored research programs. The sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03d897c55f05e8bd82f7d5a59b4b0b39
https://pubmed.ncbi.nlm.nih.gov/27734387
https://pubmed.ncbi.nlm.nih.gov/27734387
Publikováno v:
Methods in Molecular Biology ISBN: 9781493964284
Two developments have greatly facilitated the construction of CCN mutant mouse strains. The first is the availability of modified embryonic stem (ES) cells and mice developed through several large-scale government-sponsored research programs. The sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::859b17e0522ce6e39773554c2ba38c44
https://doi.org/10.1007/978-1-4939-6430-7_28
https://doi.org/10.1007/978-1-4939-6430-7_28