Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Zhengqi Cheng"'
Autor:
Youmna Ali, Tahiatul Shams, Ke Wang, Zhengqi Cheng, Yue Li, Wenying Shu, Xiaofeng Bao, Ling Zhu, Michael Murray, Fanfan Zhou
Publikováno v:
Chinese Medicine, Vol 15, Iss 1, Pp 1-10 (2020)
Abstract Organic anion transporting polypeptides (OATPs) are important transporter proteins that are expressed at the plasma membrane of cells, where they mediate the influx of endogenous and exogenous substances including hormones, natural compounds
Externí odkaz:
https://doaj.org/article/0e5642c9d572432dbfc11c2c987a90b0
Publikováno v:
Journal of Pharmacy and Pharmacology. 75:385-396
ObjectivesRetinal Müller glial cell loss is almost involved in all retinal diseases, especially diabetic retinopathy (DR). Oxidative stress significantly contributes to the development of Müller glial cell loss. Ginkgo biloba extracts (GBE) have be
Autor:
Yue Li, Xiaofeng Bao, Zhengqi Cheng, Ling Zhu, Tahiatul Shams, Chelsea Siu-wai Chun, Wenying Shu, Fanfan Zhou, Michael Murray, Youmna Ali
Publikováno v:
Journal of Pharmaceutical Sciences. 110:914-924
The Wnt/β-catenin signaling pathway is dysregulated in diseases and Wnt inhibitors like PRI-724 are in clinical development. This study evaluated the regulatory actions of PRI-724 and other Wnt inhibitors on the transport activity of human renal Org
Publikováno v:
Expert opinion on therapeutic patents. 32(5)
Introduction: The blockade of immune checkpoints, especially the PD-1/PD-L1 pathway with therapeutic antibodies, has shown success in treating cancers in recent years. Seven monoclonal antibodies (mAbs) targeting PD-1 or PD-L1 have been approved by F
Autor:
Ting Zhang, Fanfan Zhou, Michael Murray, Yue Li, Wenying Shu, Xue Zhu, Ke Wang, Youmna Ali, Zhengqi Cheng, Ling Zhu
Publikováno v:
Planta medica. 87(7)
Retinal diseases are a leading cause of impaired vision and blindness but some lack effective treatments. New therapies are required urgently to better manage retinal diseases. Natural pentacyclic triterpenoids and their derivatives have a wide range
Autor:
Zhengqi Cheng, Yue Li, Ke Wang, Xue Zhu, Priyanka Tharkar, Wenying Shu, Ting Zhang, Shaoxue Zeng, Ling Zhu, Michael Murray, Wojciech Chrzanowski, Fanfan Zhou
Publikováno v:
Experimental Eye Research. 215:108906
Müller cells maintain homeostatic functions in the retina. Their dysfunction leads to irreversible retinal diseases. Oxidative injury is a leading cause of retinal cytotoxicity. Our previous studies reported several betulinic acid (BA) derivatives c
Autor:
Fanfan Zhou, Youmna Ali, Ke Wang, Xue Zhu, Xiaohui Fan, Wenying Shu, Xiaofeng Bao, Zhengqi Cheng, Ling Zhu, Michael Murray, Yue Li
Publikováno v:
Experimental Eye Research. 207:108586
Oxidative stress plays an important role in the pathogenesis of human retinal diseases. Ginkgo biloba products are widely consumed herbal supplements that contain ingredients with anti-oxidant potentials. However, the active agents in ginkgo biloba e
Autor:
Michael Murray, Weimin Ding, Jian Zheng, Yue Li, Yang Wang, Fanfan Zhou, Ling Zhu, Ting Zhang, Zhengqi Cheng
Publikováno v:
Experimental cell research. 383(1)
Muller cells are the predominant retinal glial cells. One of the key roles of Muller cells is in the uptake of the neurotransmitter glutamate and in its conversion to glutamine. Muller cell dysfunction due to oxidative stress elicited by high glutama
Autor:
Weimin Ding, Ting Zhang, Wenjuan Yao, Ling Zhu, Yang Wang, Jian Zheng, Zhengqi Cheng, Fanfan Zhou
Publikováno v:
Experimental eye research. 180
The Retinal Pigment Epithelium (RPE) is a monolayer of cells located above the choroid. It mediates human visual cycle and nourishes photoreceptors. Hypoxia-induced oxidative stress to RPE is a vital cause of retinal degeneration such as the Age-rela
Publikováno v:
Molecular pharmacology. 94(6)
The organic anion transporting polypeptides (OATPs) are important membrane proteins that mediate the cellular uptake of drugs and endogenous substances. OATP1A2 is widely distributed in many human tissues that are targeted in drug therapy; defective