Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Zhengping Shao"'
Publikováno v:
BMC Cardiovascular Disorders, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Many studies have shown that both elevated serum uric acid (SUA) levels and hyperhomocysteinemia are risk factors for atherosclerosis. However, the relationship between the two has not been thoroughly investigated. Objective This
Externí odkaz:
https://doaj.org/article/4e86522a8dc846b59a64c406fb8c0a96
Autor:
Demis Menolfi, Wenxia Jiang, Brian J. Lee, Tatiana Moiseeva, Zhengping Shao, Verna Estes, Mark G. Frattini, Christopher J. Bakkenist, Shan Zha
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
ATR kinase is a key regulator of chromosome integrity. Here the authors by analysing the phenotype of a mouse model expressing a kinase-dead ATR, reveal the effect of ATR inhibition compared to ATR loss and its consequences for meiosis, DNA replicati
Externí odkaz:
https://doaj.org/article/7c2497d431244adcb615e18c3e661a2e
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Non-homologous end-joining is the key pathway for repairing double-stranded DNA breaks in mammalian cells. Here the authors show that PAXX promotes the accumulation of KU at DNA breaks and is essential for end-joining in cells lacking XLF.
Externí odkaz:
https://doaj.org/article/b22beddb938e4935afca7966266c756f
Autor:
Hailong Wang, Linda Z Shi, Catherine C L Wong, Xuemei Han, Patty Yi-Hwa Hwang, Lan N Truong, Qingyuan Zhu, Zhengping Shao, David J Chen, Michael W Berns, John R Yates, Longchuan Chen, Xiaohua Wu
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003277 (2013)
CtIP plays an important role in homologous recombination (HR)-mediated DNA double-stranded break (DSB) repair and interacts with Nbs1 and BRCA1, which are linked to Nijmegen breakage syndrome (NBS) and familial breast cancer, respectively. We identif
Externí odkaz:
https://doaj.org/article/8606f4a68b27439399514e14dd129d54
Autor:
Zhengping Shao, Brian J. Lee, Hanwen Zhang, Xiaohui Lin, Chen Li, Wenxia Jiang, Napon Chirathivat, Steven Gershik, Michael M. Shen, Richard Baer, Shan Zha
PARP1 is recruited and activated by DNA strand breaks, catalyzing the generation of poly-ADP-ribose (PAR) chains from NAD+. PAR relaxes chromatin and recruits other DNA repair factors, including XRCC1 and DNA Ligase 3, to maintain genomic stability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3ff5a5f348ddafd663173d43c96f1aa
https://doi.org/10.1101/2023.05.23.542022
https://doi.org/10.1101/2023.05.23.542022
Autor:
Yuanyuan Li, Richa B. Shah, Samanta Sarti, Alicia L. Belcher, Brian J. Lee, Andrej Gorbatenko, Francesca Nemati, Ian Yu, Zoe Stanley, Zhengping Shao, Jose M. Silva, Shan Zha, Samuel Sidi
Publikováno v:
bioRxiv
Interleukin-1 receptor (IL-1R)-associated kinases (IRAKs) are core effectors of Toll-like receptor (TLR) and IL-1R signaling, with no reported roles outside of innate immunity. We find that vertebrate cells exposed to ionizing radiation (IR) sequenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145271a44514f51d38e0476c189df026
https://doi.org/10.1101/2023.02.08.527716
https://doi.org/10.1101/2023.02.08.527716
Autor:
Keith W. Caldecott, Zhengping Shao, Kouji Hirota, Annie A. Demin, Shan Zha, Jan Brazina, Hana Hanzlikova, Shunichi Takeda, Marek Adamowicz, Masataka Tsuda, William Gittens, Richard Hailstone, Ilona Kalasova, Hiroyuki Sasanuma
Publikováno v:
Molecular Cell
Summary Mammalian DNA base excision repair (BER) is accelerated by poly(ADP-ribose) polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect single-strand break intermediates, but the critical role of XRCC1 during BER is unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e86818528d3dada10d5a783f3caced
http://hdl.handle.net/2433/263313
http://hdl.handle.net/2433/263313
Autor:
Patrick Aoude, Ryan A. Flynn, Verna M Estes, Jennifer L. Crowe, Yimeng Zhu, Shan Zha, Fardin Aryan, Govind Bhagat, Wenxia Jiang, Zhengping Shao, Carolyn R. Bertozzi, Jialiang Liang, Eliezer Calo, Brian J. Lee
Publikováno v:
Nature. 579:291-296
The DNA-dependent protein kinase (DNA-PK), which comprises the KU heterodimer and a catalytic subunit (DNA-PKcs), is a classical non-homologous end-joining (cNHEJ) factor1. KU binds to DNA ends, initiates cNHEJ, and recruits and activates DNA-PKcs. K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f44e3d90a3ba5982616af4bdd231330c
https://doi.org/10.1038/s41586-020-2041-2
https://doi.org/10.1038/s41586-020-2041-2
Autor:
Verna M Estes, Riccardo Dalla-Favera, Laura Pasqualucci, Zhengping Shao, Olivia M Cupo, Brian J. Lee, Yimeng Zhu, Richard Baer, Stefanie N. Meyer, Jean Gautier, Foon Wu-Baer, Marco Fangazio, Demis Menolfi, Shan Zha, Yunyue Wang, Xiaobin S Wang
Publikováno v:
Proc Natl Acad Sci U S A
CtIP is a DNA end resection factor widely implicated in alternative end-joining (A-EJ)–mediated translocations in cell-based reporter systems. To address the physiological role of CtIP, an essential gene, in translocation-mediated lymphomagenesis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2e7e37665e93c3836767752b5b84dd
https://pubmed.ncbi.nlm.nih.gov/34521752
https://pubmed.ncbi.nlm.nih.gov/34521752
Autor:
Brian J. Lee, Shan Zha, Zhengping Shao, Verna M Estes, Jennifer L. Crowe, Xiaobin S Wang, Wenxia Jiang, Xiaohui Lin
Publikováno v:
J Immunol
The classical nonhomologous end-joining (cNHEJ) pathway is a major DNA double-strand break repair pathway in mammalian cells and is required for lymphocyte development and maturation. The DNA-dependent protein kinase (DNA-PK) is a cNHEJ factor that e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd941744da4a36e992a5508583c8a552
https://doi.org/10.4049/jimmunol.1801657
https://doi.org/10.4049/jimmunol.1801657