Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Zhengpeng Wan"'
Autor:
Giovanni S. Offeddu, Elena Cambria, Sarah E. Shelton, Kristina Haase, Zhengpeng Wan, Luca Possenti, Huu Tuan Nguyen, Mark R. Gillrie, Dean Hickman, Charles G. Knutson, Roger D. Kamm
Publikováno v:
Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)
Abstract Desmoplasia in breast cancer leads to heterogeneity in physical properties of the tissue, resulting in disparities in drug delivery and treatment efficacy among patients, thus contributing to high disease mortality. Personalized in vitro bre
Externí odkaz:
https://doaj.org/article/a394968a50cf4ecb907cb7897f5472c7
Autor:
Zhengpeng Wan, Shun Zhang, Amy X. Zhong, Liling Xu, Mark F. Coughlin, Georgios Pavlou, Sarah E. Shelton, Huu Tuan Nguyen, Satomi Hirose, Seunggyu Kim, Marie A. Floryan, David A. Barbie, F. Stephen Hodi, Roger D. Kamm
Publikováno v:
Advanced Science, Vol 11, Iss 26, Pp n/a-n/a (2024)
Abstract Endothelial programmed death‐ligand 1 (PD‐L1) expression is higher in tumors than in normal tissues. Also, tumoral vasculatures tend to be leakier than normal vessels leading to a higher trans‐endothelial or transmural fluid flow. Howe
Externí odkaz:
https://doaj.org/article/e0b6d2b3cd9a4d6185b943c5ce795bda
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Emerging microfluidic disease models have amply demonstrated their value in many fields of cancer research. These in vitro technologies recapitulate key aspects of metastatic cancer, including the process of tumor cell arrest and extravasation at the
Externí odkaz:
https://doaj.org/article/8d82b4c37e894d67817ee4e9d383b109
Autor:
Giovanni S. Offeddu, Cynthia Hajal, Colleen R. Foley, Zhengpeng Wan, Lina Ibrahim, Mark F. Coughlin, Roger D. Kamm
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Offeddu et al. employ a microfluidic vascular model to study the effects of selective removal of glycocalyx components from cancer cells. They find that cancer-associated hyaluronic acid and CD44 mediate firm adhesion to endothelial cells and extrava
Externí odkaz:
https://doaj.org/article/43b59cb8b39a432e9084aba3c7f1be2c
Publikováno v:
Bio-Protocol, Vol 10, Iss 18 (2020)
B lymphocyte activation is regulated by its membrane-bound B cell receptors (BCRs) upon recognizing diverse antigens. It is hypothesized that antigen binding would trigger conformational changes within BCRs, followed by a series of downstream signali
Externí odkaz:
https://doaj.org/article/4ab0228c214f4bada03909d00d499c7e
Publikováno v:
eLife, Vol 8 (2019)
B lymphocytes use B cell receptors (BCRs) to recognize antigens. It is still not clear how BCR transduces antigen-specific physical signals upon binding across cell membrane for the conversion to chemical signals, triggering downstream signaling casc
Externí odkaz:
https://doaj.org/article/6716669f68dc49cdb08d6c31f4de08e9
Autor:
Samina Shaheen, Zhengpeng Wan, Zongyu Li, Alicia Chau, Xinxin Li, Shaosen Zhang, Yang Liu, Junyang Yi, Yingyue Zeng, Jing Wang, Xiangjun Chen, Liling Xu, Wei Chen, Fei Wang, Yun Lu, Wenjie Zheng, Yan Shi, Xiaolin Sun, Zhanguo Li, Chunyang Xiong, Wanli Liu
Publikováno v:
eLife, Vol 6 (2017)
The mechanosensing ability of lymphocytes regulates their activation in response to antigen stimulation, but the underlying mechanism remains unexplored. Here, we report that B cell mechanosensing-governed activation requires BCR signaling molecules.
Externí odkaz:
https://doaj.org/article/53442122ceb94add81f255cfd8082d1e
Autor:
Zhengpeng Wan, Xiangjun Chen, Haodong Chen, Qinghua Ji, Yingjia Chen, Jing Wang, Yiyun Cao, Fei Wang, Jizhong Lou, Zhuo Tang, Wanli Liu
Publikováno v:
eLife, Vol 4 (2015)
B lymphocytes use B cell receptors (BCRs) to sense the physical features of the antigens. However, the sensitivity and threshold for the activation of BCRs resulting from the stimulation by mechanical forces are unknown. Here, we addressed this quest
Externí odkaz:
https://doaj.org/article/4dd3978ba64a4f358e4353f822caa50b
Autor:
Shaosen Zhang, Liling Xu, Xingwang Zhao, Xin Chen, Yilin Fan, Zhengpeng Wan, Yinsheng Xu, Wanli Liu
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63735 (2013)
Our understanding of cell-cell interactions has been significantly improved in the past years with the help of Total Internal Reflection Fluorescence Microscope (TIRFM) in combination with an antigen presenting system supported by planar lipid bilaye
Externí odkaz:
https://doaj.org/article/4a43be57ef634339a854db0013d33cc8
Publikováno v:
Advanced functional materials. 32(43)
Self-organized microvascular networks (MVNs) have become key to the development of many microphysiological models. However, the self-organizing nature of this process combined with variations between types or batches of endothelial cells (ECs) often