Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3

Autor: Zhicheng Zuo, Rachel N. Smith, Zhenglan Chen, Amruta S. Agharkar, Heather D. Snell, Renqi Huang, Jin Liu, Eric B. Gonzales

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Acid-sensing ion channels (ASICs) sense changes in extracellular acidity with Ca2+ as an allosteric modulator and channel blocker. Here authors use electrophysiology and molecular dynamics simulation to identify the residue in ASIC3 which modulates p

Externí odkaz: https://doaj.org/article/13f55aaea8244e21bacd420c63712ecc

Transient focal cerebral ischemia induces long-term cognitive function deficit in an experimental ischemic stroke model

Autor: Wenjun Li, Renqi Huang, Ritu A. Shetty, Nopporn Thangthaeng, Ran Liu, Zhenglan Chen, Nathalie Sumien, Margaret Rutledge, Glenn H. Dillon, Fang Yuan, Michael J. Forster, James W. Simpkins, Shao-Hua Yang

Publikováno v: Neurobiology of Disease, Vol 59, Iss , Pp 18-25 (2013)

Vascular dementia ranks as the second leading cause of dementia in the United States. However, its underlying pathophysiological mechanism is not fully understood and no effective treatment is available. The purpose of the current study was to evalua

Externí odkaz: https://doaj.org/article/48476f63c5e54d069fc744ea902fdcfd

Coronaridine congeners potentiate GABAA receptors and induce sedative activity in mice in a benzodiazepine-insensitive manner

Autor: Eric B. Gonzales, Abdeslam Chagraoui, Jean-Claude do Rego, Zhenglan Chen, Hugo R. Arias, Jean Luc Do Rego, Petra Scholze, Youssef Anouar, Ren-Qi Huang

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Elsevier, 2020, 101, pp.109930-. ⟨10.1016/j.pnpbp.2020.109930⟩
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020, 101, pp.109930-. ⟨10.1016/j.pnpbp.2020.109930⟩

To determine whether (+)-catharanthine induces sedative- or anxiolytic/anxiogenic-like activity in male mice, proper animal paradigms were used. The results showed that (+)-catharanthine induces sedative-like activity in the 63–72 mg/Kg dose range

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f072900d98100766457d7ace03d54c4
https://hal.archives-ouvertes.fr/hal-03489760

Pancreatic mitochondrial complex I exhibits aberrant hyperactivity in diabetes

Autor: Zhenglan Chen, Siqun Jing, Nopporn Thangthaeng, Xiaoting Luo, Jinzi Wu, Liang-Jun Yan, Michael J. Forster, Margaret A. Rutledge, Nathalie Sumien

Publikováno v: Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 11, Iss C, Pp 119-129 (2017)

It is well established that NADH/NAD+ redox balance is heavily perturbed in diabetes, and the NADH/NAD+ redox imbalance is a major source of oxidative stress in diabetic tissues. In mitochondria, complex I is the only site for NADH oxidation and NAD+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46b1162a720bb73a03edc7e424211ba
https://doi.org/10.1016/j.bbrep.2017.07.007

Methylene blue inhibits GABA A receptors by interaction with GABA binding site

Autor: Zhenglan Chen, Glenn H. Dillon, Ran Liu, Shao-Hua Yang, Ren-Qi Huang

Publikováno v: Neuropharmacology. 119:100-110

Methylene blue (MB) is commonly used in diagnostic procedures and is also used to treat various medical conditions. Neurological effects of MB have been reported in clinical observations and experimental studies. Thus the modulation of GABA A recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1378c01b9efbaec259c8ff83f1733cc
https://doi.org/10.1016/j.neuropharm.2017.04.002