Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Zhengjun Cai"'
Autor:
Bai Li, Xian‐Hao Zhou, Peng‐Yu Yang, Liping Zhu, Yuan Zhong, Zhengjun Cai, Biao Jiang, Xiaoqing Cai, Jia Liu, Xianxing Jiang
Publikováno v:
Advanced Science, Vol 6, Iss 13, Pp n/a-n/a (2019)
Abstract Fluorogenic labeling enables imaging cellular molecules of interest with minimal background. This process is accompanied with the notable increase of the quantum yield of fluorophore, thus minimizing the background signals from unactivated p
Externí odkaz:
https://doaj.org/article/97b9467cf8924621be5f67f495be7bdb
Autor:
Bao Cheng, Zhengjun Cai, Ziqing Luo, Siting Luo, Zhiteng Luo, Yanfang Cheng, Ying Yu, Junsong Guo, Yingchen Ju, Qiong Gu, Jun Xu, Xianxing Jiang, Geng Li, Huihao Zhou
Publikováno v:
Journal of medicinal chemistry. 65(23)
Aminoacyl-tRNA synthetases (aaRSs) are promising antimicrobial targets due to their essential roles in protein translation, and expanding their inhibitory mechanisms will provide new opportunities for drug discovery. We report here that halofuginone
Design, Synthesis, and Proof-of-Concept of Triple-Site Inhibitors against Aminoacyl-tRNA Synthetases
Autor:
Zhengjun Cai, Bingyi Chen, Ying Yu, Junsong Guo, Zhiteng Luo, Bao Cheng, Jun Xu, Qiong Gu, Huihao Zhou
Publikováno v:
Journal of medicinal chemistry. 65(7)
Aminoacyl-tRNA synthetases (aaRSs) are promising drug targets due to their essential roles in protein translation. Although current inhibitors primarily occupy one or two of the three substrate binding sites on aaRSs, we report here the structure-bas
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 27(49)
A room temperature, visible-light-promoted and redox neutral direct C-H amination of glycine and peptides has been firstly accomplished by using N-acyloxyphthalimide or -succinimide as nitrogen-radical precursor. The present strategy provides ways to
Publikováno v:
Journal of Materials Chemistry A. 7:26358-26363
Energy-efficient ammonia synthesis from facile electrochemical N2 fixation is desirable in many fields such as fertilizer production and carbon-free energy carriers. However, it remains challenging due to the difficulty of N2 adsorption and dissociat
Publikováno v:
Bioorganic chemistry. 114
DNA gyrase is an essential DNA topoisomerase that exists only in bacteria. Since novobiocin was withdrawn from the market, new scaffolds and new mechanistic GyrB inhibitors are urgently needed. In this study, we employed fragment screening and X-ray
Publikováno v:
Chemical Communications. 54:2353-2356
Herein, a copper-catalyzed highly diastereoselective aerobic oxygenated [3+3] cyclization of 3-substituted indoles with C,N-cyclic azomethine imines using oxygen as the sole oxidant under mild conditions has been developed. This protocol provides a s
Autor:
Huihao Zhou, Jieyu Tang, Qiong Gu, Bingyi Chen, Bao Cheng, Jun Xu, Zhengjun Cai, Ying Yu, Junsong Guo, Yingchen Ju
Publikováno v:
European Journal of Medicinal Chemistry. 207:112848
Aminoacyl-tRNA synthetases (aaRSs) are an attractive class of antibacterial drug targets due to their essential roles in protein translation. While most traditional aaRS inhibitors target the binding pockets of substrate amino acids and/or ATP, we re
Publikováno v:
Sensors and Actuators B: Chemical. 303:127230
The physisorption strategy is an universal sensing principle in fluorescent platform design, which have realized the successful detection for various targets based on nanomaterial-enabled sensors. However, this type of ”turn-on” biosensor is stil