Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Zhengjian Lv"'
Autor:
Natalie Landeck, Katherine E. Strathearn, Daniel Ysselstein, Kerstin Buck, Sayan Dutta, Siddhartha Banerjee, Zhengjian Lv, John D. Hulleman, Jagadish Hindupur, Li-Kai Lin, Sonal Padalkar, Lia A. Stanciu, Yuri L. Lyubchenko, Deniz Kirik, Jean-Christophe Rochet
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-23 (2020)
Abstract Background α-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson’s disease (PD). Mouse aSyn contains a threonine residue at position 53 that mimics th
Externí odkaz:
https://doaj.org/article/577ae13724214a3bac084228b03fe4b4
Autor:
Jean-Christophe Rochet, Karen Zagorski, Siddhartha Banerjee, Yuri L. Lyubchenko, Mohtadin Hashemi, Zhengjian Lv
Publikováno v:
Biochim Biophys Acta Proteins Proteom
The spontaneous self-assembly of α-synuclein (α-syn) into aggregates of different morphologies is associated with the development of Parkinson’s disease. However, the mechanism behind the spontaneous assembly remains elusive. The current study sh
Autor:
Yuri L. Lyubchenko, Sonal Padalkar, John D. Hulleman, Siddhartha Banerjee, Li-Kai Lin, Lia Stanciu, Katherine E. Strathearn, Zhengjian Lv, Daniel Ysselstein, Deniz Kirik, Natalie Landeck, Kerstin Buck, Sayan Dutta, Jagadish Hindupur, Jean-Christophe Rochet
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-23 (2020)
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-23 (2020)
Background α-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson’s disease (PD). Mouse aSyn contains a threonine residue at position 53 that mimics the human f
Autor:
Landeck, Natalie, Strathearn, Katherine E., Ysselstein, Daniel, Buck, Kerstin, Sayan Dutta, Siddhartha Banerjee, Zhengjian Lv, Hulleman, John D., Jagadish Hindupur, Li-Kai Lin, Padalkar, Sonal, Stanciu, Lia A., Lyubchenko, Yuri L., Kirik, Deniz, Rochet, Jean-Christophe
Additional file 1: Figure S1. Differences in antibody recognition of the different aSyn variants. Related to Fig. 3. Figure S2. Human/mouse mismatches at positions 121 and 122 do not affect the ability of aSyn to form Proteinase K-resistant aggregate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b090ecc79ebfb5a10faebab30416b2af
Autor:
George P. McCabe, Siddhartha Banerjee, Kerstin Buck, Jean-Christophess Rochet, Zhengjian Lv, Katherine E. Strathearn, Li-Kai Lin, Yuri L. Lyubchenko, John D. Hulleman, Sayan Dutta, Natalie Landeck, Sonal Padalkar, Lia Stanciu, Deniz Kirik, Daniel Ysselstein, Jagadish Hindupur
α-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson’s disease (PD). Mouse aSyn contains a threonine residue at position 53 that mimics the human familial PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1640699a2db2538440fc7e73a4ff8214
https://doi.org/10.1101/700377
https://doi.org/10.1101/700377
Publikováno v:
Nanoscale advances. 1(10)
The self-assembly and fibrillation of amyloid β (Aβ) proteins is the neuropathological hallmark of Alzheimer’s disease. However, the molecular mechanism of how disordered monomers assemble into aggregates remains largely unknown. In this work, we
Publikováno v:
Nanoscale. 8:18928-18937
The self-assembly of amyloid (Aβ) proteins into nano-aggregates is a hallmark of Alzheimer’s disease (AD) development, yet the mechanism of how disordered monomers assemble into aggregates remains elusive. Here, we applied long-time molecular dyna
Autor:
Zhengjian Lv, Karen Zagorski, Mohtadin Hashemi, Siddhartha Banerjee, Yuri L. Lyubchenko, Chris Rochet
Development of Parkinson’s disease is associated with spontaneous self-assembly of α-synuclein (α-syn). Efforts aimed at understanding this process have produced little clarity and the mechanism remains elusive. We report a novel effect of phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f0392048d65f8d9313fc2fa0981689
Autor:
Yuri L. Lyubchenko, Benfeard Williams, Yuliang Zhang, Konstantin I. Popov, Mohtadin Hashemi, Zhengjian Lv, Nikolay V. Dokholyan
α-Synuclein (α-syn) is the major component of the intraneuronal inclusions called Lewy bodies, which are the pathological hallmark of Parkinson's disease. α-Syn is capable of self-assembly into many different species, such as soluble oligomers and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c3de6bde1885da5930c6a11c967c4a
https://europepmc.org/articles/PMC5764752/
https://europepmc.org/articles/PMC5764752/
Publikováno v:
Methods in Molecular Biology ISBN: 9781493985906
Nanoimaging methods, atomic force microscopy (AFM) in particular, are widely used to study the interaction of biological molecules with the supported lipid bilayer (SLB), which itself is a traditional model for cellular membranes. Success in these st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946e54a3b104ae79e2eb86262e3d8be8
https://doi.org/10.1007/978-1-4939-8591-3_8
https://doi.org/10.1007/978-1-4939-8591-3_8