Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Zhenghe John Wang"'
Publikováno v:
Molecular Cancer Research. 18:PR09-PR09
Glutamine addiction is a major metabolic reprogramming event that occurs in cancer cells. Many tumors exhibit oncogene-dependent addiction to glutamine. As a metabolite, glutamine is first converted to glutamate by glutaminase (GLS) and then to α-ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3d5f6152dc443a747b103100eb27697
https://doi.org/10.1158/1557-3125.pi3k-mtor18-pr09
https://doi.org/10.1158/1557-3125.pi3k-mtor18-pr09
Publikováno v:
Journal of Visualized Experiments.
Alternative splicing (AS) occurs in more than 90% of human genes. The expression pattern of an alternatively spliced exon is often regulated in a cell type-specific fashion. AS expression patterns are typically analyzed by RT-PCR and RNA-seq using RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10bb9476b26151b3428be40f78fb041c
https://doi.org/10.3791/57889-v
https://doi.org/10.3791/57889-v
Autor:
Petra Platzer, Lois Myeroff, Baozhong Xin, Arman Nosrati, Debra Mikkola, Revital Kariv, Joseph Willis, Earl Lawrence, Stephen P. Fink, Sanford D. Markowitz, Jill S. Barnholtz-Sloan, Marty L Veigl, Nathan Morris, Zhenghe John Wang, James K V Willson
Publikováno v:
Oncotarget
Genes induced in colon cancer provide novel candidate biomarkers of tumor phenotype and aggressiveness. We originally identified KIAA1199 (now officially called CEMIP) as a transcript highly induced in colon cancer: initially designating the transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2891650d6d61862792548de54c30338
https://doi.org/10.18632/oncotarget.5921
https://doi.org/10.18632/oncotarget.5921
Autor:
Ahmad M. Khalil, Xing-Huang Gao, Mark W. Jackson, Sanford D. Markowitz, Lydia Beard, Callie R. Merry, Jessica N. Sabers, Zhenghe John Wang, Maria Hatzoglou, Megan E. Forrest
Publikováno v:
Human Molecular Genetics. 24:6240-6253
The cancer epigenome exhibits global loss of DNA methylation, which contributes to genomic instability and aberrant gene expression by mechanisms that are yet to be fully elucidated. We previously discovered over 3300 long non-coding (lnc)RNAs in hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f1815b6255c218ea1c64388ace0a01
https://doi.org/10.1093/hmg/ddv343
https://doi.org/10.1093/hmg/ddv343
Autor:
Jianing Xu, Huan Xiong, Yaping Li, Zhongyao Ma, Zhenghe John Wang, Stephen Dalton, Edward T. Kipreos, Shaying Zhao
Publikováno v:
Oncoscience
AVL9, DENND5A and NUPL1 are among the cancer driver candidate genes previously identified via dog-human comparison, and may function in epithelial cell polarity as indicated by bioinformatics analysis. To better understand their cellular functions an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfde321a4c800f5a5d5a76cc30241f89
http://europepmc.org/articles/PMC4303893
http://europepmc.org/articles/PMC4303893
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(24)
To follow up on our recent discovery of the 18-amino acid all-hydrocarbon [i, i + 4]-stapled p110α[E545K] peptide 1 that was shown to potently block the intracellular p110α[E545K]-IRS1 interaction (a protein-protein interaction uniquely present in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa10bfa30faa8269c410061021465442
https://pubmed.ncbi.nlm.nih.gov/29138025
https://pubmed.ncbi.nlm.nih.gov/29138025
Autor:
Bing Su, Xing Chen, Matthew F. Kalady, C. Clare Blackburn, Julie Carman, Yina H. Huang, Caini Liu, Zhenghe John Wang, Xiaoxia Li, Yujun Hao, Wenjun Ouyang, Junjie Zhao, Ling Wu, Jun Zhu, Katazyna Bulek, Thomas A. Hamilton, Wen Pin Yang, Xinxin Wang, Jarod A. Zepp
This study identifies a novel mechanism linking IL-17A with colon tissue repair and tumor development. Abrogation of IL-17A signaling in mice attenuated tissue repair of dextran sulfate sodium (DSS)-induced damage in colon epithelium and markedly red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8169e6ace6a9fced569f2efb10094cc0
https://ruj.uj.edu.pl/xmlui/handle/item/47794
https://ruj.uj.edu.pl/xmlui/handle/item/47794
Autor:
Zhenghe John Wang
Publikováno v:
Genes & Diseases. 5:301
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a897a88b224fd2bf06875dbb7e7903a
https://doi.org/10.1016/j.gendis.2018.11.004
https://doi.org/10.1016/j.gendis.2018.11.004
Publikováno v:
Toxicologic Pathology. 42:140-147
Phosphoinositide-3-kinase, catalytic, alpha polypeptide, which encodes the catalytic p110α subunit of phosphatidylinositol 3-kinase α, is the most frequently mutated oncogene in human cancers. Targeting mutant p110α holds great promise for cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809472b533625a0018279d2d6f64c8cf
https://doi.org/10.1177/0192623313506794
https://doi.org/10.1177/0192623313506794
Autor:
Marty L Veigl, Shuying Sun, Xiaoqing Yu, Joseph Willis, Mark Raymond Adams, Sanford D. Markowitz, Zhenghe John Wang, Kishore Guda, Neil Molyneux
Publikováno v:
Modern Pathology. 25:1599-1608
The advent of Next-Generation sequencing technologies, which significantly increases the throughput and reduces the cost of large-scale sequencing efforts, provides an unprecedented opportunity for discovery of novel gene mutations in human cancers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988ed26bc6b96a81769315970d46910d
https://doi.org/10.1038/modpathol.2012.121
https://doi.org/10.1038/modpathol.2012.121