Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Zhengdong D Zhang"'
Autor:
Kejun Ying, José P. Castro, Anastasia V. Shindyapina, Alexander Tyshkovskiy, Mahdi Moqri, Ludger J. E. Goeminne, Sofiya Milman, Zhengdong D. Zhang, Nir Barzilai, Vadim N. Gladyshev
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract While previous studies identified common genetic variants associated with longevity in centenarians, the role of the rare loss-of-function (LOF) mutation burden remains largely unexplored. Here, we investigated the burden of rare LOF mutatio
Externí odkaz:
https://doaj.org/article/5caa0089e32b4109a566c31b600051c0
Publikováno v:
PLoS Genetics, Vol 13, Iss 12, p e1007142 (2017)
Rare variants of major effect play an important role in human complex diseases and can be discovered by sequencing-based genome-wide association studies. Here, we introduce an integrated approach that combines the rare variant association test with g
Externí odkaz:
https://doaj.org/article/2a97883dc59a454f8e44fe214afb992e
Autor:
M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Nha Nguyen, Tina Gao, Mark Khusidman, Sanish Sathyan, Gil Atzmon, Sofiya Milman, Jan Vijg, Nir Barzilai, Zhengdong D. Zhang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract The highly polygenic nature of human longevity renders pleiotropy an indispensable feature of its genetic architecture. Leveraging the genetic correlation between aging-related traits (ARTs), we aimed to model the additive variance in lifesp
Externí odkaz:
https://doaj.org/article/e7089311efc14bf3834f43d096b8f9b4
Autor:
Siming Ma, Akhil Upneja, Andrzej Galecki, Yi-Miau Tsai, Charles F Burant, Sasha Raskind, Quanwei Zhang, Zhengdong D Zhang, Andrei Seluanov, Vera Gorbunova, Clary B Clish, Richard A Miller, Vadim N Gladyshev
Publikováno v:
eLife, Vol 5 (2016)
Mammalian lifespan differs by >100 fold, but the mechanisms associated with such longevity differences are not understood. Here, we conducted a study on primary skin fibroblasts isolated from 16 species of mammals and maintained under identical cell
Externí odkaz:
https://doaj.org/article/f1463509a367443e8f5a6529b84fbddb
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 7, p e1000432 (2009)
The goal of human genome re-sequencing is obtaining an accurate assembly of an individual's genome. Recently, there has been great excitement in the development of many technologies for this (e.g. medium and short read sequencing from companies such
Externí odkaz:
https://doaj.org/article/078c8cf4cb174ee6bafbbb0292600c7b
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 8, p e1000158 (2008)
ChIP sequencing (ChIP-seq) is a new method for genomewide mapping of protein binding sites on DNA. It has generated much excitement in functional genomics. To score data and determine adequate sequencing depth, both the genomic background and the bin
Externí odkaz:
https://doaj.org/article/2fcb413ab5d94f73811dcc7e09949e21
Autor:
Yingjie Zhao, Yujue Wang, Lijie Shi, Donna M. McDonald-McGinn, T. Blaine Crowley, Daniel E. McGinn, Oanh T. Tran, Daniella Miller, Jhih-Rong Lin, Elaine Zackai, H. Richard Johnston, Eva W. C. Chow, Jacob A. S. Vorstman, Claudia Vingerhoets, Therese van Amelsvoort, Doron Gothelf, Ann Swillen, Jeroen Breckpot, Joris R. Vermeesch, Stephan Eliez, Maude Schneider, Marianne B. M. van den Bree, Michael J. Owen, Wendy R. Kates, Gabriela M. Repetto, Vandana Shashi, Kelly Schoch, Carrie E. Bearden, M. Cristina Digilio, Marta Unolt, Carolina Putotto, Bruno Marino, Maria Pontillo, Marco Armando, Stefano Vicari, Kathleen Angkustsiri, Linda Campbell, Tiffany Busa, Damian Heine-Suñer, Kieran C. Murphy, Declan Murphy, Sixto García-Miñaúr, Luis Fernández, International 22q11.2 Brain and Behavior Consortium (IBBC), Zhengdong D. Zhang, Elizabeth Goldmuntz, Raquel E. Gur, Beverly S. Emanuel, Deyou Zheng, Christian R. Marshall, Anne S. Bassett, Tao Wang, Bernice E. Morrow
Publikováno v:
npj Genomic Medicine, Vol 8, Iss 1, Pp 1-15 (2023)
Abstract Congenital heart disease (CHD) affecting the conotruncal region of the heart, occurs in 40–50% of patients with 22q11.2 deletion syndrome (22q11.2DS). This syndrome is a rare disorder with relative genetic homogeneity that can facilitate i
Externí odkaz:
https://doaj.org/article/8c4a618d8f784a9c9f58db40b2e0cf57
Autor:
M. Reza Jabalameli, Zhengdong D. Zhang
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Since the start of the COVID-19 global pandemic, our understanding of the underlying disease mechanism and factors associated with the disease severity has dramatically increased. A recent study investigated the relationship between substance use dis
Externí odkaz:
https://doaj.org/article/8e8bff32dfda4ecba597c2d461a90014
Autor:
Quanwei Zhang, Zhengdong D. Zhang
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101692- (2022)
Summary: Although gene expansion plays an important role in evolution, its identification remains a challenge due to potential errors in genome assembly and annotation. Here, we describe a detailed step-by-step protocol for gene annotation, predictio
Externí odkaz:
https://doaj.org/article/311b9ce8a7574126b4b924ae36c65104
Autor:
Zhen Wang, Quanwei Zhang, Jhih-Rong Lin, M. Reza Jabalameli, Joydeep Mitra, Nha Nguyen, Zhengdong D. Zhang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Alzheimer’s disease (AD) is a genetically complex, multifactorial neurodegenerative disease. It affects more than 45 million people worldwide and currently remains untreatable. Although genome-wide association studies (GWAS) have identifie
Externí odkaz:
https://doaj.org/article/d240b06944584aa79ba071b19c689ac5