Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Zheng-yun Zhao"'
Autor:
Rosemary A Bamford, Zheng-yun Zhao, Neil A Hotchin, Iain B Styles, Gerard B Nash, James H R Tucker, Roy Bicknell
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95097 (2014)
Förster resonance energy transfer (FRET) technology relies on the close proximity of two compatible fluorophores for energy transfer. Tagged (Cy3 and Cy5) complementary DNA strands forming a stable duplex and a doubly-tagged single strand were shown
Externí odkaz:
https://doaj.org/article/23aa865591bc45d09f4e17ec94de7e68
Autor:
Xiaoya Guan, Qiming An, Xiuyun Tian, Zheng-Yun Zhao, Chunyi Hao, Ang Lv, Jianhui Wu, Bin Dong, Chengpeng Li, Wei Xu
Publikováno v:
International Journal of Medical Sciences
International journal of medical sciences, 2020, Vol.17(18), pp.3073-3081 [Peer Reviewed Journal]
International journal of medical sciences, 2020, Vol.17(18), pp.3073-3081 [Peer Reviewed Journal]
Patient-derived xenograft (PDX) models are effective preclinical cancer models that reproduce the tumor microenvironment of the human body. The methods have been widely used for drug screening, biomarker development, co-clinical trials, and personali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45b058dea886c8d198ad7b339459986
http://europepmc.org/articles/PMC7646096
http://europepmc.org/articles/PMC7646096
Autor:
James H. R. Tucker, Dario M. Bassani, Zheng-yun Zhao, Gemma A. Bullen, Anna F. A. Peacock, John Wilkie, Jean-Louis H. A. Duprey
Publikováno v:
ACS Chemical Biology. 11:717-721
The ability to discriminate between epigenetic variants in DNA is a necessary tool if we are to increase our understanding of the roles that they play in various biological processes and medical conditions. Herein, it is demonstrated how a simple two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f94a657849fc56e2f5ac415319a9bc1
https://doi.org/10.1021/acschembio.5b00796
https://doi.org/10.1021/acschembio.5b00796
Autor:
Dario M. Bassani, Gediminas Jonusauskas, John Wilkie, Jean-Louis H. A. Duprey, Christian Ludwig, Neil Spencer, Joseph S. Vyle, Alison Rodger, James H. R. Tucker, Eva I. Hyde, Zheng-yun Zhao
Publikováno v:
Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2018, 16 (35), pp.6576-6585. ⟨10.1039/c8ob01710g⟩
Duprey, J-L H A, Bassani, D M, Hyde, E I, Jonusauskas, G, Ludwig, C, Rodger, A, Spencer, N, Vyle, J S, Wilkie, J, Zhao, Z-Y & Tucker, J H R 2018, ' Rationalisation of a mechanism for sensing single point variants in target DNA using anthracene-tagged base discriminating probes ', Organic & biomolecular chemistry, vol. 16, no. 35, pp. 6576-6585 . https://doi.org/10.1039/C8OB01710G, https://doi.org/10.1039/c8ob01710g
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2018, 16 (35), pp.6576-6585. ⟨10.1039/c8ob01710g⟩
Duprey, J-L H A, Bassani, D M, Hyde, E I, Jonusauskas, G, Ludwig, C, Rodger, A, Spencer, N, Vyle, J S, Wilkie, J, Zhao, Z-Y & Tucker, J H R 2018, ' Rationalisation of a mechanism for sensing single point variants in target DNA using anthracene-tagged base discriminating probes ', Organic & biomolecular chemistry, vol. 16, no. 35, pp. 6576-6585 . https://doi.org/10.1039/C8OB01710G, https://doi.org/10.1039/c8ob01710g
International audience; The labelling of DNA oligonucleotides with signalling groups that give a unique response to duplex formation depending on the target sequence is a highly effective strategy in the design of DNA-based hybridisation sensors. A k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf7b10e74d7ea7fe9ca258418c3a1dd
https://hal.archives-ouvertes.fr/hal-01953231/file/DupreyOBC2018.pdf
https://hal.archives-ouvertes.fr/hal-01953231/file/DupreyOBC2018.pdf
Publikováno v:
Synthesis. 46:2815-2825
The synthesis of C4-linked imidazole C 0 - and C 2 -2′-deoxyribonucleoside phosphoramidites (dPAs), in which the final phosphitylations are greatly improved by 4,5-dicyanoimidazole-promoted conversion, is described. The respective dPAs are successf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e6c4684a841a3de7912ee478fa9004
https://doi.org/10.1055/s-0034-1378451
https://doi.org/10.1055/s-0034-1378451
Autor:
Mihoyo Fujitake, Yoshihide Usami, Timothy J. Wilson, Zheng-yun Zhao, Daiki Fujisue, David M.J. Lilley, Masayoshi Nishiura, Scott A. McPhee, Shinya Harusawa, Hiroki Yoneyama
Publikováno v:
Tetrahedron Letters. 53:5891-5894
Novel C5-linked C0- and C2-tetrazole ribonucleoside phosphoramidites were designed and synthesized via tetrazole C-nucleosides. Pivaloyloxymethyl (POM) and methyl-substituted POM (MePOM) groups were introduced as N-protecting groups in the tetrazole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58878e58d40c93684ee91f0b429d256c
https://doi.org/10.1016/j.tetlet.2012.08.082
https://doi.org/10.1016/j.tetlet.2012.08.082
Autor:
James H. R. Tucker, Zheng-yun Zhao, Luciano Giordano, Dario M. Bassani, Joseph S. Vyle, Jack Manchester, Jean-Louise H. A. Duprey
Publikováno v:
Journal of the American Chemical Society
Manchester, J, Bassani, D M, Duprey, J-L H A, Giordano, L, Vyle, J S, Zhao, Z & Tucker, J H R 2012, ' Photocontrolled Binding and Binding-Controlled Photochromism within Anthracene-Modified DNA ', Journal of the American Chemical Society, vol. 134, no. 26, pp. 10791-10794 . https://doi.org/10.1021/ja304205m
Manchester, J, Bassani, D M, Duprey, J-L H A, Giordano, L, Vyle, J S, Zhao, Z & Tucker, J H R 2012, ' Photocontrolled Binding and Binding-Controlled Photochromism within Anthracene-Modified DNA ', Journal of the American Chemical Society, vol. 134, no. 26, pp. 10791-10794 . https://doi.org/10.1021/ja304205m
Modified DNA strands undergo a reversible light-induced reaction involving the intramolecular photodimerization of two appended anthracene tags. The photodimers exhibit markedly different binding behavior toward a complementary strand that depends on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56060d592759166c4fbdebf59aba274d
http://europepmc.org/articles/PMC3614019
http://europepmc.org/articles/PMC3614019
Autor:
Zheng-yun Zhao, Joseph S. Vyle, James H. R. Tucker, John R. Arrand, Jean-Louis H. A. Duprey, Marie San
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:129-132
Single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer were identified using oligodeoxynucleotide probe sequences bearing internal anthracene fluorophores proximal to the SNP site. Depending upon the nature of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09ba9eeaba115ba1ac3322594743985
https://doi.org/10.1016/j.bmcl.2011.11.053
https://doi.org/10.1016/j.bmcl.2011.11.053
Autor:
Keiji Morita, David M.J. Lilley, Zheng-yun Zhao, Shinya Harusawa, Timothy J. Wilson, Maho Yamaguchi, Lisa Araki
Publikováno v:
The Journal of Organic Chemistry. 74:2350-2356
The synthesis of a novel C4-linked C2-imidazole ribonucleoside phosphoramidite (ICN-C2-PA 1) with a two-carbon linker between imidazole and ribose moieties is described. In the phosphoramidite, POM and 2-cyanoethyl groups were selected to protect the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6304f373ac64cd53afd74050bc5e9d4b
https://doi.org/10.1021/jo802556s
https://doi.org/10.1021/jo802556s
Autor:
David M.J. Lilley, Natsumi Taniguchi, Zheng-yun Zhao, Maho Yamaguchi, Takushi Kurihara, Sumi Yonezawa, Shinya Harusawa, Lisa Araki
Publikováno v:
Tetrahedron. 61:11976-11985
We describe the synthesis of novel C4-linked imidazole ribonucleoside phosphoramidite (PA) 1a by which the imidazole moiety is incorporated into VS ribozyme to study its role in general acid and base catalysis. Investigation of protecting groups for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53bba2836a8cdb12a16723aa9c256f6a
https://doi.org/10.1016/j.tet.2005.09.063
https://doi.org/10.1016/j.tet.2005.09.063