Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Zheng-Yi Chen"'
Autor:
Yong Tao, Veronica Lamas, Wan Du, Wenliang Zhu, Yiran Li, Madelynn N. Whittaker, John A. Zuris, David B. Thompson, Arun Prabhu Rameshbabu, Yilai Shu, Xue Gao, Johnny H. Hu, Charles Pei, Wei-Jia Kong, Xuezhong Liu, Hao Wu, Benjamin P. Kleinstiver, David R. Liu, Zheng-Yi Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mutations in Atp2b2, an outer hair cell gene, cause dominant hearing loss in humans. Using a mouse model Atp2b2 Obl/+, with a dominant hearing loss mutation (Oblivion), we show that liposome-mediated in vivo delivery of CRISPR-Cas9 ribonucle
Externí odkaz:
https://doaj.org/article/a29936b8a683497cbbd1b953799336a4
Autor:
Longlong Zhang, Hui Wang, Mengzhao Xun, Honghai Tang, Jinghan Wang, Jun Lv, Biyun Zhu, Yuxin Chen, Daqi Wang, Shaowei Hu, Ziwen Gao, Jianping Liu, Zheng-Yi Chen, Bing Chen, Huawei Li, Yilai Shu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101154- (2023)
Pathogenic mutations in the OTOF gene cause autosomal recessive hearing loss (DFNB9), one of the most common forms of auditory neuropathy. There is no biological treatment for DFNB9. Here, we designed an OTOF gene therapy agent by dual-adeno-associat
Externí odkaz:
https://doaj.org/article/9201e8bb5dec4aaeb92965f6e0ea9271
Autor:
Chong Cui, Daqi Wang, Bowei Huang, Fang Wang, Yuxin Chen, Jun Lv, Luping Zhang, Lei Han, Dong Liu, Zheng-Yi Chen, Geng-Lin Li, Huawei Li, Yilai Shu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 400-412 (2022)
Gene therapy would benefit from the effective editing of targeted cells with CRISPR-Cas9 tools. However, it is difficult to precisely assess the editing performance in vivo because the tissues contain many non-targeted cells, which is one of the majo
Externí odkaz:
https://doaj.org/article/00257e5ff9874d46b092959adb4ca12b
Autor:
Ziwen Zheng, Guo Li, Chong Cui, Fang Wang, Xiaohan Wang, Zhijiao Xu, Huiping Guo, Yuxin Chen, Honghai Tang, Daqi Wang, Mingqian Huang, Zheng-Yi Chen, Xingxu Huang, Huawei Li, Geng-Lin Li, Xiaoxiang Hu, Yilai Shu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract CRISPR/RfxCas13d (CasRx) editing system can specifically and precisely cleave single-strand RNAs, which is a promising treatment for various disorders by downregulation of related gene expression. Here, we tested this RNA-editing approach on
Externí odkaz:
https://doaj.org/article/eee9aef78fce4fff90a9e45b4bc297b6
Autor:
Kun Zhang, Xiaoting Cheng, Liping Zhao, Mingqian Huang, Yong Tao, Hongbo Zhang, Jessica M. Rosenholm, Min Zhuang, Zheng-Yi Chen, Bing Chen, Yilai Shu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 511-519 (2020)
The aim of this study was to study an antimicrobial peptide (AMP), aurein 1.2, which substantially increased protein delivery directly into multiple mammalian inner-ear cell types in vivo. Different concentrations of aurein 1.2 with superpositively c
Externí odkaz:
https://doaj.org/article/d2aee4dce9a34d5d9f682a3445bbe603
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2022)
The study of an adult mammalian auditory system, such as regeneration, has been hampered by the lack of an in vitro system in which hypotheses can be tested efficiently. This is primarily due to the fact that the adult inner ear is encased in the tou
Externí odkaz:
https://doaj.org/article/5801755671124afbae803d61a737dbd7
Autor:
Yilai Shu, Wenyan Li, Mingqian Huang, Yi-Zhou Quan, Deborah Scheffer, Chunjie Tian, Yong Tao, Xuezhong Liu, Konrad Hochedlinger, Artur A. Indzhykulian, Zhengmin Wang, Huawei Li, Zheng-Yi Chen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The adult mammalian inner ear cells cannot regenerate nor proliferate. Here, the authors show that co-activation of Myc and NOTCH pathways can stimulate proliferation of inner ear sensory epithelial cells, which can be induced to become hair cell-lik
Externí odkaz:
https://doaj.org/article/ffede07f9adb4b84bc66e2e78aa02c57
Autor:
Nicholas C. Gosstola, Zaohua Huang, Xiaoying Tong, Aida Nourbakhsh, Zheng-Yi Chen, Derek M. Dykxhoorn, Xue Zhong Liu
Publikováno v:
Stem Cell Research, Vol 49, Iss , Pp 102017- (2020)
UMi028-A-1 hiPSC line contains a CRISPR/Cas9-induced heterozygous, hearing loss-associated variant (V60L (GTA > TTA)) in the Purinergic Receptor P2X2 (P2RX2) gene. This line, derived from an unaffected male iPSC line, has been successfully characteri
Externí odkaz:
https://doaj.org/article/40d0ee6b88e94a7dad955dcb5db7417a
Publikováno v:
New Journal of Physics, Vol 22, Iss 9, p 093005 (2020)
Spin-transfer torque (STT) applications in magnetization switching such as magnetic tunnel junctions (MTJs) have been of popular interest in the development of novel memory technologies. However, the high switching power associated with these is a cr
Externí odkaz:
https://doaj.org/article/cacaa77a8bf6468494b5bf96b1ffe5d7
Autor:
Shaofeng Liu, Yunfeng Wang, Yongtian Lu, Wen Li, Wenjing Liu, Jun Ma, Fuqin Sun, Mao Li, Zheng-Yi Chen, Kaiming Su, Wenyan Li
Publikováno v:
Neural Plasticity, Vol 2018 (2018)
Inner ear formation requires that a series of cell fate decisions and morphogenetic events occur in a precise temporal and spatial pattern. Previous studies have shown that transcription factors, including Pax2, Sox2, and Prox1, play important roles
Externí odkaz:
https://doaj.org/article/78c0a6d481a640b8a36afbf0ceef10b2