Type 1 diabetes: treat the symptoms or cure the disease?

Autor: Peter G. Jones, Zheng-Liang Zhi, Aileen King, Shanta J. Persaud

Publikováno v: The Biochemist. 38:5-9

Islet transplantation has shown great promise as an experimental treatment for Type 1 diabetes, but current clinical protocols have problems with long-term graft survival when islets are transplanted into an inflammatory, immunogenic host environment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adc72561c078a3bdf027aaf1ba4ea720
https://doi.org/10.1042/bio03804005

Fluorescence Intensity- and Lifetime-Based Glucose Sensing Using Glucose/Galactose-Binding Protein

Autor: Jonathan Coulter, Faaizah Khan, Zheng-Liang Zhi, John C. Pickup, David J. S. Birch

Publikováno v: Journal of Diabetes Science and Technology. 7:62-71

We review progress in our laboratories toward developing in vivo glucose sensors for diabetes that are based on fluorescence labeling of glucose/galactose-binding protein. Measurement strategies have included both monitoring glucose-induced changes i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d775be507aa30dfcd0c889c19a3de72
https://doi.org/10.1177/193229681300700108

Nano-scale encapsulation enhances allograft survival and function of islets transplanted in a mouse model of diabetes

Autor: Zheng-Liang Zhi, Alan Kerby, John C. Pickup, Aileen King, Peter M. Jones

Publikováno v: Zhi, Z-I, Kerby, A, King, A J F, Jones, P M & Pickup, J C 2012, ' Nano-scale encapsulation enhances allograft survival and function of islets transplanted in a mouse model of diabetes ', Diabetologia, vol. 55, no. 4, N/A, pp. 1081-1090 . https://doi.org/10.1007/s00125-011-2431-y

The success of islet transplantation as a treatment for type 1 diabetes is currently hampered by post-transplantation loss of functional islets through adverse immune and non-immune reactions. We aimed to test whether early islet loss can be limited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d401eba38cbfb6d49019a68326c65f
https://doi.org/10.1007/s00125-011-2431-y

Pseudoislets as primary islet replacements for research

Autor: Neville H. McClenaghan, Mark Russell, Tania Maffucci, Mark D. Turner, Noel G. Morgan, Aileen King, Catherine Arden, Claire Marriott, Shanta J. Persaud, Adrian J. Bone, Astrid C Hauge-Evans, MustafaY.G. Younis, Christina Reers, Moira Harrison, Peter Bergsten, James Brown, Emma Willoughby, Catriona Kelly, Simon J. Dunmore, Zheng-Liang Zhi, Peter M. Jones

Publikováno v: Islets. 2:236-239

Laboratory-based research aimed at understanding processes regulating insulin secretion and mechanisms underlying beta-cell dysfunction and loss in diabetes often makes use of rodents, as these processes are in many respects similar between rats/mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29239bac9464eb3328ad240e506af645
https://doi.org/10.4161/isl.2.4.12557

A Versatile Gold Surface Approach for Fabrication and Interrogation of Glycoarrays

Autor: Rositsa Karamanska, Josef Voglmeir, Sabine L. Flitsch, Robert A. Field, Paul R. Crocker, Margherita Fais, Nicolas Laurent, Andrew K. Powell, Jeremy E. Turnbull, Zheng-Liang Zhi, Adam Wright, David A. Russell, Jonathan M. Blackburn

Publikováno v: ChemBioChem. 9:1568-1575

Glycoarrays on gold: A designer gold surface incorporating a self-assembled monolayer with weak protein absorption properties has been optimised for rapid display and interrogation of both native and derivatised glycans in array formats. This rapid,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d071f79c42d68835544b7d56edf3844b
https://doi.org/10.1002/cbic.200700788