Zobrazeno 1 - 10
of 354
pro vyhledávání: '"Zheng-Hong Qin"'
Autor:
Ji-Chuan Liu, Xiu-Yun Zhao, Ming-Lei Wu, Yi-fan Shi, Ze-Ping Huang, Li-Pao Fang, Chao Zhu, Xuan Peng, Zi-Ling Shi, Li-Jun Lan, Wen-Li Ji, Li Luo, Lei Feng, Zeng-Li Zhang, De-en Xu, Shao Li, Zheng-Hong Qin, Yan-Yun Sun, Melitta Schachner, Quan-Hong Ma
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-17 (2024)
Abstract Neurons rely heavily on high mitochondrial metabolism to provide sufficient energy for proper development. However, it remains unclear how neurons maintain high oxidative phosphorylation (OXPHOS) during development. Mitophagy plays a pivotal
Externí odkaz:
https://doaj.org/article/a156d36b40004d2b8152d6ad79d8307b
Autor:
Na Liu, Wei-Long Wu, Xiao-Rui Wan, Jing Wang, Jia-Ni Huang, Yi-Yue Jiang, Yi-Chao Sheng, Jun-Chao Wu, Zhong-Qin Liang, Zheng-Hong Qin, Yan Wang
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103176- (2024)
Excitotoxicity is a prevalent pathological event in neurodegenerative diseases. The involvement of ferroptosis in the pathogenesis of excitotoxicity remains elusive. Transcriptome analysis has revealed that cytoplasmic reduced nicotinamide adenine di
Externí odkaz:
https://doaj.org/article/3c3de55a7f404d049347076c2d826fcc
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116689- (2024)
Ischemic heart disease invariably leads to devastating damage to human health. Nicotinamide ribose (NR), as one of the precursors of NAD+ synthesis, has been discovered to exert a protective role in various neurological and cardiovascular disorders.
Externí odkaz:
https://doaj.org/article/fe699c37aba6406bbd2ef4b77ac3cdad
Publikováno v:
Experimental Gerontology, Vol 178, Iss , Pp 112226- (2023)
Evidence from clinical studies and preclinical studies supports that exercise preconditioning can not only reduce the risk of stroke but also improve brain tissue and functional outcome after stroke. It has been demonstrated that autophagy and mitoch
Externí odkaz:
https://doaj.org/article/8bc827a0d9fd44ed9b590fc3bbbd3352
Publikováno v:
Brain Hemorrhages, Vol 3, Iss 2, Pp 62-76 (2022)
Cerebral conditioning is defined as the mild harmful stimuli applied to the brain before ischemia (preconditioning), during ischemia (perconditioning), immediately, a few hours or days after reperfusion (postconditioning). Various noxious stimuli can
Externí odkaz:
https://doaj.org/article/ae9d3a1417a84d94bbcbf1e12647d4cb
Autor:
Xin-Xin Wang, Guang-Hui Mao, Qi-Qi Li, Jie Tang, Hua Zhang, Kang-Lin Wang, Lei Wang, Hong Ni, Rui Sheng, Zheng-Hong Qin
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Ischemic stroke seriously threatens human health because of high rates of morbidity, mortality and disability. This study compared the effects of nicotinamide adenine dinucleotide (NAD+) and butylphthalide (NBP) on in vitro and in vivo is
Externí odkaz:
https://doaj.org/article/d5e6d979d2144001803d8d4760f2150f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/94d22828fa1b4e5490fee84828127d13
Autor:
Lan-Lan Tan, Xiao-Lu Jiang, Li-Xiao Xu, Gen Li, Chen-Xi Feng, Xin Ding, Bin Sun, Zheng-Hong Qin, Zu-Bin Zhang, Xing Feng, Mei Li
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 6, Pp 1037-1043 (2021)
Our previous studies have demonstrated that TP53-induced glycolysis and apoptosis regulator (TIGAR) can protect neurons after cerebral ischemia/reperfusion. However, the role of TIGAR in neonatal hypoxic-ischemic brain damage (HIBD) remains unknown.
Externí odkaz:
https://doaj.org/article/5d17489d68fc4386aa1d3ff10a79b467
Autor:
Jie Fang, Jing She, Fang Lin, Jun-Chao Wu, Rong Han, Rui Sheng, Guanghui Wang, Zheng-Hong Qin
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Neuroinflammation plays an important role in the pathogenesis of many central nervous system diseases. Here, we investigated the effect of an anti-cancer compound RRx-001 on neuroinflammation and its possible new applications. BV2 cells and primary m
Externí odkaz:
https://doaj.org/article/3466de6661ca41828479621ba47fd531
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-15 (2019)
Abstract Background Macroautophagy (hereafter autophagy) is a tightly regulated process that delivers cellular components to lysosomes for degradation. Damage-regulated autophagy modulator 1 (DRAM1) induces autophagy and is necessary for p53-mediated
Externí odkaz:
https://doaj.org/article/e826e6c8635641adb38fe0ef494755e3