Sulfonamidyl derivatives of sigmacidin: Protein-protein interaction inhibitors targeting bacterial RNA polymerase and sigma factor interaction exhibiting antimicrobial activity against antibiotic-resistant bacteria

Autor: Ye, Jiqing, Kan, Cheuk Hei, Zheng, Yingbo, Tsang, Tsz Fung, Chu, Adrian Jun, Chan, King Hong, Yang, Xiao, Ma, Cong

Publikováno v: In Bioorganic Chemistry February 2024 143

Synthesis and biological evaluation of nusbiarylin derivatives as bacterial rRNA synthesis inhibitor with potent antimicrobial activity against MRSA and VRSA

Autor: Qiu, Yangyi, Chu, Adrian Jun, Tsang, Tsz Fung, Zheng, Yingbo, Lam, Nga Man, Li, Kendra Sek Lam, Ip, Margaret, Yang, Xiao, Ma, Cong

Publikováno v: In Bioorganic Chemistry July 2022 124

Discovery of secondary sulphonamides as IDO1 inhibitors with potent antitumour effects in vivo

Autor: Haiqing Zhong, Yue Hu, Yi Zou, Wang Fang, Yisheng Lai, Yan Wang, Li Yuezhen, Wenjie Guo, Ge Shushan, Qiang Xu, Zheng Yingbo, Wen Liu, Xuewei Ma

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1240-1257 (2020)

Indoleamine 2,3-dioxygenase 1 (IDO1) as a key rate-limiting enzyme in the kynurenine pathway of tryptophan metabolism plays an important role in tumour immune escape. Herein, a variety of secondary sulphonamides were synthesised and evaluated in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23cbfdc5ca8196d2396f0bf3ee09ccc8
http://europepmc.org/articles/PMC7336998

Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors

Autor: Qiang Xu, Yisheng Lai, Ge Shushan, Wen Liu, Zheng Yingbo, Li Yuezhen, Yihua Zhang, Yi Zou, Wenjie Guo, Yue Hu

Publikováno v: European journal of medicinal chemistry. 184

Developing small molecules occupying the heme-binding site using computational approaches remains a challenging task because it is difficult to characterize heme-ligand interaction in heme-containing protein. Indoleamine 2,3-dioxygenase 1 (IDO1) is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb9967f97f476aae8fac8ea48b32114
https://pubmed.ncbi.nlm.nih.gov/31610376

P-67: An Analytical Method of Small-Sized Module Waving Based on the Finite-Element Simulation.

Autor: Zhang, Bingchuan, Zheng, Yingbo, Lin, Yanfeng, Zhou, Gege, Lv, Chengling

Publikováno v: SID Symposium Digest of Technical Papers; May2017, Vol. 48 Issue 1, p1494-1497, 4p