Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Zheng Xiufang"'
Publikováno v:
In European Journal of Medicinal Chemistry 29 September 2017 138:1147-1157
Akademický článek
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Autor:
Hongying Yun, Lu Gao, Lisha Wang, Baoxia Wang, Yongfu Liu, Mingwei Zhou, Kunlun Xiang, Zhang Bo, Li Chen, Xin Yu, Tao Guo, Chungen Liang, Song Feng, Jim Zhen Wu, Gang Zou, Zheng Xiufang, Hong C. Shen
Publikováno v:
Journal of Medicinal Chemistry. 62:6003-6014
Ziresovir (RO-0529, AK0529) is reported here for the first time as a promising respiratory syncytial virus (RSV) fusion (F) protein inhibitor that currently is in phase 2 clinical trials. This article describes the process of RO-0529 as a potent, sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eaa43b9bc9f40799676e30d45f3892a
https://doi.org/10.1021/acs.jmedchem.9b00654
https://doi.org/10.1021/acs.jmedchem.9b00654
Publikováno v:
European Journal of Medicinal Chemistry. 138:1147-1157
Recently we described a novel class of imidazopyridine compounds that showed exceptional anti-RSV potency in cell culture. However, unfavorable pharmacokinetic (PK) properties and glutathione (GSH) adduct liabilities impeded their further development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74699e4654757955fd9f3d33be82313f
https://doi.org/10.1016/j.ejmech.2017.07.032
https://doi.org/10.1016/j.ejmech.2017.07.032
Autor:
Zhu Wei, Lei Guo, Baoxia Wang, Miao Kun, Lisha Wang, Zheng Xiufang, Song Feng, Chungen Liang, Hong C. Shen, Guolong Wu, Chen Dongdong, Hongying Yun, Lu Gao, Weixing Zhang
Publikováno v:
Medchemcomm
A new class of indole derivatives (3) have been identified as potent RSV fusion inhibitors. SAR exploration revealed that 5-Cl and the sulfonyl side chain of the indole scaffold are crucial for anti-RSV activity. Further optimization led to the disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180c65792d2bb072fc10c821201a899a
https://pubmed.ncbi.nlm.nih.gov/31303995
https://pubmed.ncbi.nlm.nih.gov/31303995
Discovery of Piperazinylquinoline Derivatives as Novel Respiratory Syncytial Virus Fusion Inhibitors
Autor:
Baoxia Wang, Lisha Wang, Lu Gao, Song Feng, Zheng Xiufang, Kunlun Xiang, Hongying Yun, Miao Kun, Hong C. Shen
Publikováno v:
ACS Medicinal Chemistry Letters. 7:558-562
A novel series of piperazinylquinoline derivatives were discovered as respiratory syncytial virus (RSV) fusion inhibitors by the ligand-based screening approach. Among 3,000 hits, 1-amino-3-[[2-(4-phenyl-1-piperidyl)-4-quinolyl]amino]propan-2-ol (7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5a52c1473719a2a30c6e86f7da7db7
https://doi.org/10.1021/acsmedchemlett.5b00234
https://doi.org/10.1021/acsmedchemlett.5b00234
Autor:
Lisha Wang, Hong C. Shen, Zheng Xiufang, Tao Guo, Hongying Yun, Chungen Liang, Lu Gao, Yongfu Liu, Li Chen, Jim Zhen Wu, Song Feng, Baoxia Wang, Lichun Feng
Publikováno v:
Journal of medicinal chemistry. 61(22)
A novel benzoazepinequnoline (BAQ) series was discovered as RSV fusion inhibitors. BAQ series originated from compound 2, a hit from similarity-based virtual screening. In SAR exploration, benzoazepine allowed modifications in the head moiety. Benzyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b75956bd86e61d2115a5a922809751
https://pubmed.ncbi.nlm.nih.gov/30339388
https://pubmed.ncbi.nlm.nih.gov/30339388
Publikováno v:
Journal of Organic & Inorganic Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::877f35b0a9eaa974deed1dda959f90e7
https://doi.org/10.21767/2472-1123-c3-009
https://doi.org/10.21767/2472-1123-c3-009
Akademický článek
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Akademický článek
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