Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Zheng Jason Yuan"'
Autor:
C. Kors van der Ent, Renske van der Meer, Sylvia F. Boj, Robert G.J. Vries, Harry G.M. Heijerman, Peter van Mourik, Paul K. Audhya, Jamie R Doyle, Jeffrey M. Beekman, Zheng Jason Yuan, N. Kinnman, Gitte Berkers
Publikováno v:
Journal of Cystic Fibrosis. 20:761-767
Background Previous in vitro organoid data showed A455E–CFTR, a rare CFTR mutation with 4.1% prevalence in the Netherlands, responds to lumacaftor/ivacaftor (LUM/IVA). We explored LUM/IVA's clinical efficacy in people with CF and ≥1 A455E–CFTR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e7cd4bc1b9aa6bdfa4cf0c9c20123f
https://doi.org/10.1016/j.jcf.2020.11.007
https://doi.org/10.1016/j.jcf.2020.11.007
Autor:
Penelope A. Kosinski, Charles Kung, Elizabeth Merica, Bruce Silver, Hua Yang, Ann J Barbier, Marvin Cohen, Lee Silverman, Ronald Goldwater, Sam Agresta, Meredith Goldwasser, Zheng Jason Yuan, Yue Chen
Publikováno v:
Clinical pharmacology in drug development. 8(2)
Pyruvate kinase deficiency is a chronic hemolytic anemia caused by mutations in PK-R, a key glycolytic enzyme in erythrocytes. These 2 phase 1 randomized, placebo-controlled, double-blind healthy-volunteer studies assessed the safety, tolerability, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe2cedadddf60f10ed779ebb08b7ae7
https://pubmed.ncbi.nlm.nih.gov/30091852
https://pubmed.ncbi.nlm.nih.gov/30091852
Autor:
Eduard J. van Beers, Zheng (Jason) Yuan, D. Holmes Morton, Christian Rose, Penelope A. Kosinski, Frédéric Galactéros, Bruce Silver, Kevin H.M. Kuo, Marvin Cohen, Charles Kung, D. Mark Layton, Lenny Dang, Janet L. Kwiatkowski, Jeffrey Hixon, Bertil Glader, Yaddanapudi Ravindranath, Ann J Barbier, Hassan M. Yaish, Rachael F. Grace, Hua Yang, Wilma Barcellini, Elizabeth Merica, Lee Silverman
Publikováno v:
Blood. 128:402-402
BACKGROUND Pyruvate kinase (PK) deficiency is a congenital hemolytic anemia caused by deficiency of the glycolytic enzyme red cell PK (PK-R). AG-348 is an orally available, small molecule, allosteric activator of PK-R that activates wild-type and a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::416b8e25aa3c8b750aa986d007139b2e
https://doi.org/10.1182/blood.v128.22.402.402
https://doi.org/10.1182/blood.v128.22.402.402
Autor:
Gary Connor, Susan Bodie, Kha Le, Charles Kung, Hua Yang, Chris Bowden, Penelope A. Kosinski, Ann J Barbier, Lee Silverman, Marvin Cohen, Elizabeth Merica, Zheng (Jason) Yuan
Publikováno v:
Blood. 128:1264-1264
BACKGROUND Pyruvate kinase (PK) deficiency is a congenital hemolytic anemia caused by deficiency of the glycolytic enzyme red cell PK (PK-R) due to mutations in the PKLR gene. PK catalyzes the last enzymatic step in the glycolytic pathway and is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6882c27e0912bbcac0f0b679aa2f6371
https://doi.org/10.1182/blood.v128.22.1264.1264
https://doi.org/10.1182/blood.v128.22.1264.1264