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Mutational analysis of the GDNF/RET-GDNFRα signaling complex in a kindred with vesicoureteral reflux
Autor:
Sangeeta Khorana, Sarah E. Shefelbine, Robert F. Gagel, Eileen Huang, Nicole Thobe, Gilbert J. Cote, Shuqian Jing, Gary M. Fox, Pamela N. Schultz, Zheng J. Hu
Publikováno v:
Human Genetics. 102:474-478
Glial cell line-derived neurotrophic factor (GDNF) mediates signaling across the cell membrane by interaction with the RET-GDNFR alpha receptor complex. We identified a family in which one member had medullary thyroid carcinoma (MTC) and four members