Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Zhenduo Shen"'
Autor:
Yanqun Wang, An Yan, Deyong Song, Maoqin Duan, Chuangchuang Dong, Jiantao Chen, Zihe Jiang, Yuanzhu Gao, Muding Rao, Jianxia Feng, Zhaoyong Zhang, Ruxi Qi, Xiaomin Ma, Hong Liu, Beibei Yu, Qiaoping Wang, Mengqi Zong, Jie Jiao, Pingping Xing, Rongrong Pan, Dan Li, Juxue Xiao, Junbo Sun, Ying Li, Linfeng Zhang, Zhenduo Shen, Baiping Sun, Yanyan Zhao, Lu Zhang, Jun Dai, Jingxian Zhao, Lan Wang, Changlin Dou, Zheng Liu, Jincun Zhao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The constant emergence of SARS-CoV-2 variants continues to impair the efficacy of existing neutralizing antibodies, especially XBB.1.5 and EG.5, which showed exceptional immune evasion properties. Here, we identify a highly conserved neutral
Externí odkaz:
https://doaj.org/article/c33908424c5646a8b6688faee41eaca1
Autor:
Yanqun Wang, An Yan, Deyong Song, Chuangchuang Dong, Muding Rao, Yuanzhu Gao, Ruxi Qi, Xiaomin Ma, Qiaoping Wang, Hongguang Xu, Hong Liu, Jing Han, Maoqin Duan, Shuo Liu, Xiaoping Yu, Mengqi Zong, Jianxia Feng, Jie Jiao, Huimin Zhang, Min Li, Beibei Yu, Yanxia Wang, Fanhao Meng, Xiaodan Ni, Ying Li, Zhenduo Shen, Baiping Sun, Xin Shao, Haifeng Zhao, Yanyan Zhao, Rui Li, Yanan Zhang, Guangying Du, Jun Lu, Chunna You, Hua Jiang, Lu Zhang, Lan Wang, Changlin Dou, Zheng Liu, Jincun Zhao
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-16 (2023)
Abstract SARS-CoV-2 Omicron subvariants have demonstrated extensive evasion from monoclonal antibodies (mAbs) developed for clinical use, which raises an urgent need to develop new broad-spectrum mAbs. Here, we report the isolation and analysis of tw
Externí odkaz:
https://doaj.org/article/b38531d441f14db695079f6108b97685
Structure and function analysis of a potent human neutralizing antibody CA521FALA against SARS-CoV-2
Autor:
Deyong Song, Wenbo Wang, Chuangchuang Dong, Zhenfei Ning, Xiu Liu, Chuan Liu, Guangying Du, Chunjie Sha, Kailin Wang, Jun Lu, Baiping Sun, Yanyan Zhao, Qiaoping Wang, Hongguang Xu, Ying Li, Zhenduo Shen, Jie Jiao, Ruiying Wang, Jingwei Tian, Wanhui Liu, Lan Wang, Yong-Qiang Deng, Changlin Dou
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Song et al describe and identify monoclonal antibodies that target the SARSCoV-2 Spike protein, including CA521FALA, which demonstrated neutralising potential in vivo and in vitro. They performed structural analysis, which revealed that CA521FALA rec
Externí odkaz:
https://doaj.org/article/abce2e8dd92d46c18256f52f67586310
Analytical comparability assessment on glycosylation of ziv-aflibercept and the biosimilar candidate
Publikováno v:
International journal of biological macromolecules. 180
Ziv-aflibercept (aflibercept) is a recombinant fusion protein which combines the portions of human vascular endothelial growth factor receptors extracellular domains fused to the Fc portion of human IgG1. It is a highly sialylated glycoprotein with 5
Structure and function analysis of a potent human neutralizing antibody CA521LALA against SARS-CoV-2
Autor:
Changlin Dou, Cheng-Feng Qin, Lan Wang, Deyong Song, Yong-Qiang Deng, Wenbo Wang, Chuangchuang Dong, Zhenfei Ning, Xiu Liu, Chuan Liu, Guangying Du, Chunjie Sha, Kailin Wang, Jun Lu, Baiping Sun, Yanyan Zhao, Qiaoping Wang, Hongguang Xu, Ying Li, Zhenduo Shen, Jie Jiao, Ruiying Wang, Jingwei Tian, Wanhui Liu
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, which has resulted in ~1,119,431 deaths. There is currently no approved vaccines or therapeutics for trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aff9af30add6de4b10f8f3b031aafbde
https://doi.org/10.21203/rs.3.rs-141793/v1
https://doi.org/10.21203/rs.3.rs-141793/v1
Publikováno v:
European Journal of Pharmaceutical Sciences. 115:19-24
Charge heterogeneity is often evaluated during biosimilar development as it is a universal feature of monoclonal antibodies (mAbs). A common approach in the industry is to develop a biosimilar product with a similar overall charge profile as the refe
Autor:
Xiaorui Guo, Fangxia Duan, Li Li, Xiao-Hui Chen, Zhenduo Shen, Yongfen Ma, Ping Zheng, Xiaoli Wang, Kai-shun Bi
Publikováno v:
Journal of Chromatography B. 873:51-58
A traditional Chinese medicinal preparation (TCMP) named Guanxinning lyophilized powder for injection composed of Salvia miltiorrhiza Bge. (SMB) and Ligusticum chuanxiong Hort. (LCH) was studied. In order to learn the kinetic behaviors of the lyophil
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 47:892-898
A rapid, sensitive and selective high-performance liquid chromatography tandem mass spectrometric method (HPLC-MS) has been developed and validated for the simultaneous determination of matrine (MT), oxymatrine (OMT) and oxysophocarpine (OSP) in rat
Publikováno v:
Chromatographia. 67:961-965
A rapid and sensitive LC-MS method has been developed for the determination of luteolin-7-O-β-d-glucoside in rat plasma after solvent extraction. Separation was on an Elite Hypersil ODS2 column (250 mm × 4.6 mm i.d., 5 μm) with a mobile phase of a
Publikováno v:
Chromatographia. 67:559-566
For the first time a simple, rapid, and specific liquid chromatographic–mass spectrometric (LC–MS) method for simultaneous quantification of 15 lignans from Schisandra chinensis (Turcz.) Baill. fruit has been developed and fully validated. Sample