Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Zhen-Zhong Xu"'
Autor:
Chen Zhang, Fang Tong, Bin Zhou, Mingdong He, Shuai Liu, Xiaomeng Zhou, Qiang Ma, Tianyu Feng, Wan-Jie Du, Huan Yang, Hao Xu, Lei Xiao, Zhen-Zhong Xu, Cheng Zhu, Ruiqi Wu, Yan-Qing Wang, Qingjian Han
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-17 (2024)
Abstract Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism is not fully understood yet. Here, we find that TMC6, a membrane protein of unknown function, is highly expressed in dorsal root ganglio
Externí odkaz:
https://doaj.org/article/9667939f35c440bf98b14323790ce14e
Autor:
Heng Zhang, Jia-Jia Lin, Ya-Kai Xie, Xiu-Zu Song, Jia-Yi Sun, Bei-Lei Zhang, Yun-Kun Qi, Zhen-Zhong Xu, Fan Yang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
TRPV1 as a drug target suffers from side effects of hypothermia. Here, authors engineer a peptide, sRhTx, as a positive allosteric modulator of TRPV1 channel. It potentiates the activity of TRPV1 to reversibly ablate pain-sensing nerve terminals for
Externí odkaz:
https://doaj.org/article/4f6d4493ac1f4d9c9aa5df9ee8c2731d
Autor:
Xiaoqiu Shu, Chen Wei, Wen-Yo Tu, Keke Zhong, Shuyuan Qi, Ailian Wang, Lei Bai, Shan-Xin Zhang, Benyan Luo, Zhen-Zhong Xu, Kejing Zhang, Chengyong Shen
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112133- (2023)
Summary: Expansion of the hexanucleotide repeat GGGGCC in the C9orf72 gene is the most common genetic factor in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Poly-Gly-Ala (poly-GA), one form of dipeptide repeat proteins (DPRs
Externí odkaz:
https://doaj.org/article/20ae9442036d4b84baba553156c9a090
Autor:
Lunhao Chen, Yaling Hu, Siyuan Wang, Kelei Cao, Weihao Mai, Weilin Sha, Huan Ma, Ling-Hui Zeng, Zhen-Zhong Xu, Yong-Jing Gao, Shumin Duan, Yue Wang, Zhihua Gao
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Neuropathic pain is a refractory condition that involves de novo protein synthesis in the nociceptive pathway. The mTOR is a master regulator of protein translation; however, mechanisms underlying its role in neuropathic pain remain elusive. Using th
Externí odkaz:
https://doaj.org/article/8424807da006498198accf9ed231d64c
Autor:
Aerziguli Aierken, Ya‐Kai Xie, Wenqi Dong, Abuliken Apaer, Jia‐Jia Lin, Zihan Zhao, Shilong Yang, Zhen‐Zhong Xu, Fan Yang
Publikováno v:
Advanced Science, Vol 8, Iss 22, Pp n/a-n/a (2021)
Abstract Platinum‐based compounds in chemotherapy such as oxaliplatin often induce peripheral neuropathy and neuropathic pain such as cold allodynia in patients. Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is a nociceptor critical
Externí odkaz:
https://doaj.org/article/6708c24e19d8497b9799498ae01517f0
Autor:
Hao Luo, Hui-Zhu Liu, Wen-Wen Zhang, Megumi Matsuda, Ning Lv, Gang Chen, Zhen-Zhong Xu, Yu-Qiu Zhang
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2384-2397.e5 (2019)
Summary: The proinflammatory cytokine interleukin-17 (IL-17) is implicated in pain regulation. However, the synaptic mechanisms by which IL-17 regulates pain transmission are unknown. Here, we report that glia-produced IL-17 suppresses inhibitory syn
Externí odkaz:
https://doaj.org/article/f297f1605049415dad3dca90753f9ad7
Autor:
Gang Chen, Rou-Gang Xie, Yong-Jing Gao, Zhen-Zhong Xu, Lin-Xia Zhao, Sangsu Bang, Temugin Berta, Chul-Kyu Park, Mark Lay, Wei Chen, Ru-Rong Ji
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The cellular mechanisms underlying acute pain transitions to chronic pain are poorly understood. Here the authors show that the scaffolding protein β-arrestin 2 contributes to these processes via desensitization of NMDA receptors in spinal neurons.
Externí odkaz:
https://doaj.org/article/d71d3fc96fe3477b80fc968a12f53cb5
Autor:
Linlin Zhang, Niccolò Terrando, Zhen-Zhong Xu, Sangsu Bang, Sven-Eric Jordt, William Maixner, Charles N. Serhan, Ru-Rong Ji
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Mechanisms of pain resolution are largely unclear. Increasing evidence suggests that specialized pro-resolving mediators (SPMs), derived from fish oil docosahexaenoic acid (DHA), promote the resolution of acute inflammation and potently inhibit infla
Externí odkaz:
https://doaj.org/article/c94811cb6ce14b11850909e8ebc33678
Publikováno v:
Neurosci Bull
Publikováno v:
Neuroscience bulletin.