CDK4/6 inhibition triggers ICAM1-driven immune response and sensitizes LKB1 mutant lung cancer to immunotherapy

Autor: Xue Bai, Ze-Qin Guo, Yan-Pei Zhang, Zhen-zhen Fan, Li-Juan Liu, Li Liu, Li-Li Long, Si-Cong Ma, Jian Wang, Yuan Fang, Xin-Ran Tang, Yu-Jie Zeng, Xinghua Pan, De-Hua Wu, Zhong-Yi Dong

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

LKB1 mutations have been associated with primary resistance to immune checkpoint inhibitors in patients with lung cancer. Here the authors show that Lkb1-deficient lung tumors are characterized by defective trafficking and adhesion of T cells and tha

Externí odkaz: https://doaj.org/article/cfa146b2c3c2474eb58cc188c46ec8b0

Diabetes-Induced H3K9 Hyperacetylation Promotes Development of Alzheimer’s Disease Through CDK5

Autor: Zi-Chao Li, Zhen-Zhen Fan, Ting Tian, Wen-Ting Guo, Chon-Chon Zhao, Hong-Bin Cai, Zhao-Ming Ge

Publikováno v: Journal of Alzheimer's Disease. :1-10

The connection between diabetes and Alzheimer’s disease (AD) is not fully determined. Hyperphosphorylation of tau protein is mediated by binding and stabilization of truncated p25 with cyclin-dependent kinase-5 (CDK5) in AD. We recently showed that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179fbad0564425d501bf9aa8606bde7d
https://doi.org/10.3233/jad-200163

Effect of Annealing Conditions on Recrystallization of AA5182 Sheet

Autor: Yan Xiang Liang, Xiu Chuan Lei, Xiao Fang Yang, Robert E. Sanders, Qian Ning Guo, Zhen Zhen Fan, Lu Wang

Publikováno v: Materials Science Forum. 877:264-271

Alloy 5182 has been extensively used in the O temper for automotive sheet parts requiring high formability and moderate strength. The grain size of the sheet has been shown to impact strength, formability, and Lüdering behavior during forming. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a70d81442f81403651c8ad61140249ba
https://doi.org/10.4028/www.scientific.net/msf.877.264

The Efficacy and Safety of Granulocyte Colony-Stimulating Factor for Patients with Stroke

Autor: Xiao-bin Zhai, Zhao-Ming Ge, Li-qun Wang, Hong-Bin Cai, Xu-dong Zhang, Zhen-Zhen Fan, Ling Li

Publikováno v: Journal of Stroke and Cerebrovascular Diseases. 24:1701-1708

Granulocyte colony-stimulating factor (G-CSF) has been shown to reduce lesion volume and improve functional outcome in experimental stroke models. However, whether G-CSF plays a role currently in patients with stroke remains uncertain. Our study aime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47226062b14d9f577b051e25529df835
https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.11.033

Effects of colchicine-induced microtubule depolymerization on TRPV4 in rats with chronic compression of the dorsal root ganglion

Autor: Zhen-Zhen Fan, Hong You Ge, Yang Zhang, Wei Yao, Hong Jiang, Hui Wei, Lars Arendt-Nielsen, Shouwei Yue

Publikováno v: Wei, H, Zhang, Y, Fan, Z-Z, Ge, H-Y, Arendt-Nielsen, L, Jiang, H, Yao, W & Yue, S-W 2013, ' Effects of colchicine-induced microtubule depolymerization on TRPV4 in rats with chronic compression of the dorsal root ganglion ', Neuroscience Letters, vol. 534, no. 1, pp. 344-350 . https://doi.org/10.1016/j.neulet.2012.12.003

The aim of this study was to investigate the effect of colchicine-induced microtubule depolymerization on allodynia in rats with chronic compression of the dorsal root ganglion (DRG) (CCD) and the effect of colchicine on transient receptor potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3ed67abce5e208d310d73bcd51b223
https://doi.org/10.1016/j.neulet.2012.12.003