Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Zhen-Yu J. Sun"'
Autor:
Amit K. Gandhi, Zhen-Yu J. Sun, Yu-Hwa Huang, Walter M. Kim, Chao Yang, Gregory A. Petsko, Nicole Beauchemin, Richard S. Blumberg
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
The crystal structure of human CEACAM1 IgV oligomer and structural analyses provide insight into higher-order oligomerization involving GFCC’ face-mediated homodimerization, flexible ABED interfaces, and dynamic metal-ion bridging.
Externí odkaz:
https://doaj.org/article/6e72149b314d457caf892328a8eb9172
Autor:
Amit K. Gandhi, Zhen-Yu J. Sun, Walter M. Kim, Yu-Hwa Huang, Yasuyuki Kondo, Daniel A. Bonsor, Eric J. Sundberg, Gerhard Wagner, Vijay K. Kuchroo, Gregory A. Petsko, Richard S. Blumberg
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
To understand how hCEACAM1 transitions between monomeric and dimeric states that are required for its activity, Gandhi et al. investigate hCEACAM1 homodimeric, monomeric, and transition states and their behavior in solution. This study suggests the f
Externí odkaz:
https://doaj.org/article/1e98a0721d5041b7bcee1fce74ebca91
Autor:
Azita Leavitt, Erez Yirmiya, Gil Amitai, Allen Lu, Jeremy Garb, Ehud Herbst, Benjamin R. Morehouse, Samuel J. Hobbs, Sadie P. Antine, Zhen-Yu J. Sun, Philip J. Kranzusch, Rotem Sorek
Publikováno v:
Nature. 611:326-331
Autor:
Palak Amin, Xinqian Hu, Slawomir A. Dziedzic, Heng Zhao, Junying Yuan, Zhen-Yu J. Sun, Jing Xing, Jianping Liu, Lauren Mifflin, Ayaz Najafov, Ying Qin, Masanori Gomi Naito, Daichao Xu, Bing Shan, Minzhi Jin, H. Wang, Virginia M.-Y. Lee, Li Tan, Zhuohao He, Vica Jean Manuel, Gerhard Wagner, Lingjie Yan, Jiefei Geng, Mengmeng Zhang, Hong Zhu
Publikováno v:
Nature. 587:133-138
Cell death in human diseases is often a consequence of disrupted cellular homeostasis. If cell death is prevented without restoring cellular homeostasis, it may lead to a persistent dysfunctional and pathological state. Although mechanisms of cell de
Autor:
Jia-huai Wang, Pavanjeet Kaur, Mahmoud L. Nasr, Mostafa A. Elbahnasawy, Mikyung Kim, Gerhard Wagner, Nhat Nguyen Bui, Yi Wang, Zhi-Song Qiao, Zahra Hayati, Camila Chile, Zhen-Yu J. Sun, Ellis L. Reinherz, Likai Song
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(45)
The membrane proximal external region (MPER) of HIV-1 envelope glycoprotein (gp) 41 is an attractive vaccine target for elicitation of broadly neutralizing antibodies (bNAbs) by vaccination. However, current details regarding the quaternary structura
Autor:
Jingjing Ling, Nicholas McCaul, Ross W. Cheloha, Gerhard Wagner, Zhen-Yu J. Sun, Hidde L. Ploegh
Publikováno v:
Mol Immunol
A substantial fraction of eukaryotic proteins is folded and modified in the endoplasmic reticulum (ER) prior to export and secretion. Proteins that enter the ER but fail to fold correctly must be degraded, mostly in a process termed ER-associated deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a99078e811c2b79c11352db994b0a9
https://doi.org/10.1101/700609
https://doi.org/10.1101/700609
Publikováno v:
Biochemistry. 58(10)
A 29-residue peptide (MP01), identified by in vitro selection for reactivity with a small molecule perfluoroaromatic, was modified and characterized using experimental and computational techniques, with the goal of understanding the molecular basis o
Autor:
Zhen-Yu J. Sun, Amit Gandhi, Walter M. Kim, Yasuyuki Kondo, Gerhard Wagner, Daniel A. Bonsor, Gregory A. Petsko, Vijay K. Kuchroo, Yu-Hwa Huang, Richard S. Blumberg, Eric J. Sundberg
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
T-cell immunoglobulin and mucin domain containing protein-3 (TIM-3) is an important immune regulator. Here, we describe a novel high resolution (1.7 Å) crystal structure of the human (h)TIM-3 N-terminal variable immunoglobulin (IgV) domain with boun
Autor:
James M. Hogle, Andreas Plückthun, Mike Strauss, Simina Grigoriu, Mahmoud L. Nasr, Gerhard Wagner, Thomas Walz, Sonja Huser, Franz Hagn, Zhen-Yu J. Sun, Diego Baptista
Publikováno v:
Nat. Methods 14, 49-52 (2017)
We engineered covalently circularized nanodiscs (cNDs) which, compared with standard nanodiscs, exhibit enhanced stability, defined diameter sizes and tunable shapes. Reconstitution into cNDs enhanced the quality of nuclear magnetic resonance spectra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e062b39709088aabb5f886f20891c6
https://europepmc.org/articles/PMC5199620/
https://europepmc.org/articles/PMC5199620/
Autor:
Yuxing Cheng, Melissa C. Hanson, Zhen-Yu J. Sun, Ellis L. Reinherz, J. Christopher Love, Todd M. Gierahn, Mohammed Uduman, Jaewon Choi, Darrell J. Irvine, Luke R. Donius, Mikyung Kim, Susanna Marquez, Michael H. Zhang, Steven H. Kleinstein
Publikováno v:
American Society for Microbiology
Journal of Virology
Journal of Virology
An effective preventive vaccine is highly sought after in order to stem the current HIV-1 pandemic. Both conservation of contiguous gp41 membrane-proximal external region (MPER) amino acid sequences across HIV-1 clades and the ability of anti-MPER br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4300484b6369026e8f0988eefba5b197
http://hdl.handle.net/1721.1/108061
http://hdl.handle.net/1721.1/108061