Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Zhen-Xiong Zhao"'
Autor:
Zheng-Wei Zhang, Chun-Sheng Gao, Heng Zhang, Jian Yang, Ya-Ping Wang, Li-Bin Pan, Hang Yu, Chi-Yu He, Hai-Bin Luo, Zhen-Xiong Zhao, Xin-Bo Zhou, Yu-Li Wang, Jie Fu, Pei Han, Yu-Hui Dong, Gang Wang, Song Li, Yan Wang, Jian-Dong Jiang, Wu Zhong
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 8, Pp 3298-3312 (2022)
Morinda officinalis oligosaccharides (MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted
Externí odkaz:
https://doaj.org/article/550caaf00dce49ea8a24e4a2f2b15517
Autor:
Shu-Rong Ma, Qian Tong, Yuan Lin, Li-Bin Pan, Jie Fu, Ran Peng, Xian-Feng Zhang, Zhen-Xiong Zhao, Yang Li, Jin-Bo Yu, Lin Cong, Pei Han, Zheng-Wei Zhang, Hang Yu, Yan Wang, Jian-Dong Jiang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract Trimethylamine-N-oxide (TMAO) derived from the gut microbiota is an atherogenic metabolite. This study investigates whether or not berberine (BBR) could reduce TMAO production in the gut microbiota and treat atherosclerosis. Effects of BBR o
Externí odkaz:
https://doaj.org/article/7b23508107ec49a1b8a97d37f510e106
Autor:
Yan Wang, Qian Tong, Shu-Rong Ma, Zhen-Xiong Zhao, Li-Bin Pan, Lin Cong, Pei Han, Ran Peng, Hang Yu, Yuan Lin, Tian-Le Gao, Jia-Wen Shou, Xiao-Yang Li, Xian-Feng Zhang, Zheng-Wei Zhang, Jie Fu, Bao-Ying Wen, Jin-Bo Yu, Xuetao Cao, Jian-Dong Jiang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-20 (2021)
Abstract The phenylalanine–tyrosine–dopa–dopamine pathway provides dopamine to the brain. In this process, tyrosine hydroxylase (TH) is the rate-limiting enzyme that hydroxylates tyrosine and generates levodopa (l-dopa) with tetrahydrobiopterin
Externí odkaz:
https://doaj.org/article/678b44e28f764ee2b9cc1ea4d69df7da
Autor:
Er-Fu Yang, Saowaluck Tibpromma, Samantha C. Karunarathna, Rungtiwa Phookamsak, Jian-Chu Xu, Zhen-Xiong Zhao, Chathurika Karunanayake, Itthayakorn Promputtha
Publikováno v:
Journal of Fungi, Vol 8, Iss 2, p 152 (2022)
Pleosporales is the largest fungal order with a worldwide distribution in terrestrial and aquatic environments. During investigations of saprobic fungi associated with mango (Mangifera indica) in Baoshan and Honghe, Yunnan, China, fungal taxa belongi
Externí odkaz:
https://doaj.org/article/3576ad96961b402181c53903fbced624
Autor:
Jin-Bo Yu, Zhen-Xiong Zhao, Ran Peng, Li-Bin Pan, Jie Fu, Shu-Rong Ma, Pei Han, Lin Cong, Zheng-Wei Zhang, Li-Xin Sun, Jian-Dong Jiang, Yan Wang
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Paeoniflorin, the main component of Xiaoyao Wan, presents low oral bioavailability and unclear antidepressant mechanism. To elucidate the potential reasons for the low bioavailability of paeoniflorin and explore its antidepressant mechanism from the
Externí odkaz:
https://doaj.org/article/04aa350513944a238b403ec6369211d6
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Berberine (BBR) is considered a multi-target drug that has significant advantages. In contrast to its significant pharmacological effects in clinic, the plasma level of BBR is very low. Our previous work revealed that dihydroberberine (dhBBR) could b
Externí odkaz:
https://doaj.org/article/fe8defa501f84ce4b8f7a2b7a7705a2c
Autor:
Chi-Yu He, Jie Fu, Jing-Yi Ma, Ru Feng, Xiang-Shan Tan, Min Huang, Jia-Wen Shou, Zhen-Xiong Zhao, Xiao-Yang Li, Xian-Feng Zhang, Yangchao Chen, Yan Wang
Publikováno v:
Molecules, Vol 19, Iss 7, Pp 10291-10308 (2014)
Polygonum capitatum Buch.-Ham.ex D. Don, a traditional Miao-nationality herbal medicine, has been widely used in the treatment of various urologic disorders. Recent pharmacological studies demonstrated that a pure compound, FR429, isolated from the e
Externí odkaz:
https://doaj.org/article/e542a8773a834c81821909fc118650f1
Publikováno v:
Molecules, Vol 22, Iss 6, p 932 (2017)
Gut microbiota is populated with an immense number of microorganisms, which can be regulated by dietary components and drugs to markedly affect the nutritional and health status of the host. Eight medicinal isoquinoline alkaloids from natural plants
Externí odkaz:
https://doaj.org/article/e81f0ce534e64aeab7e9bee03e2db1f5
Autor:
Jing-Yi Ma, Xuelin Zhou, Jie Fu, Chi-Yu He, Ru Feng, Min Huang, Jia-Wen Shou, Zhen-Xiong Zhao, Xiao-Yang Li, Luye Zhang, Yang-Chao Chen, Yan Wang
Publikováno v:
Molecules, Vol 21, Iss 9, p 1110 (2016)
Ellagitannin is a common compound in food and herbs, but there are few detailed studies on the metabolism of purified ellagitannins. FR429 is a purified ellagitannin with antitumor potential, which is from Polygonum capitatum Buch.-Ham.ex D. Don. The
Externí odkaz:
https://doaj.org/article/4264a245a870420983adeb773ba57752
Publikováno v:
Current Pharmaceutical Analysis. 19:83-90
Background: Genotoxic impurities (GTIs) are produced during the synthesis of active pharmaceutical ingredients and pharmaceutical excipients. L-malic acid, an important active pharmaceutical ingredient and excipient, is widely used in the pharmaceuti