Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Zhen-Qiang Pan"'
Autor:
Qing Yu, Zhiguo Hu, Yanwen Shen, Yihan Jiang, Peichen Pan, Tingjun Hou, Zhen-Qiang Pan, Jing Huang, Yi Sun
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 4, Pp 179-191 (2020)
Cullin-RING E3 ligase (CRL) is the largest family of E3 ubiquitin ligase, responsible for ubiquitylation of ∼20% of cellular proteins. CRL plays an important role in many biological processes, particularly in cancers due to abnormal activation. CRL
Externí odkaz:
https://doaj.org/article/73cda64f18ba4b59b298324d3803660c
Autor:
Chen Kong, Dmitri Samovski, Priya Srikanth, Marisa J Wainszelbaum, Audra J Charron, Jialiu Liu, Jeffrey J Lange, Pin-I Chen, Zhen-Qiang Pan, Xiong Su, Philip D Stahl
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46485 (2012)
Expression of the hominoid-specific TBC1D3 oncoprotein enhances growth factor receptor signaling and subsequently promotes cellular proliferation and survival. Here we report that TBC1D3 is degraded in response to growth factor signaling, suggesting
Externí odkaz:
https://doaj.org/article/df5dad9cf4ca41f096ab2a0bf2e65be0
Autor:
Dongmei Fan, Hongyuan Li, Yibo Wang, Zhen-Qiang Pan, Diandian Wang, Zhongwei Li, Yanyan Gao, Jun Lu, Minle Li, Junnian Zheng, Meichen Dong, Jin Bai, Baiqu Huang, Pingfu Hou, Hui Liu
Publikováno v:
Cell Death Differ
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer. However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here,
Publikováno v:
Journal of cellular signaling
Cullin-RING E3 ubiquitin ligase 4 (CRL4) plays an essential role in cell cycle progression. Recent efforts using high throughput screening and follow up hit-to-lead studies have led to identification of small molecules 33-11 and KH-4-43 that inhibit
Autor:
Zhen-Qiang Pan, Junnian Zheng, Lan Huang, Yizhou He, Meng-Han Cao, Yoko Itahana, Yingying Yang, Jin Bai, Kenneth Wu, Yu Pan, Hui Liu
Publikováno v:
Proceedings of the National Academy of Sciences. 116:11754-11763
Human homolog of mouse double minute 2 (HDM2) is an oncogene frequently overexpressed in cancers with poor prognosis, but mechanisms of controlling its abundance remain elusive. In an unbiased biochemical search, we discovered Skp1-Cullin 1-FBXO22-RO
Autor:
Clinton Yu, Zhen-Qiang Pan, Khoi Huynh, Haibin Miao, Robert J. DeVita, Iris Lu, Benjamin D. Hopkins, Roberto Sanchez, Matthew J. Haeusgen, Lan Huang, Ning Zheng, Moses Moustakim, Kenneth Wu
Publikováno v:
Proceedings of the National Academy of Sciences of USA, vol 118, iss 8
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 8
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 8
Significance Cullin-RING E3 ubiquitin ligases (CRLs) direct protein degradation to impact a myriad of physiological and pathological processes including cancer. This work reports the small-molecule compounds 33-11 and KH-4-43 as inhibitors of E3 CRL4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6fa446fc62653e2da35753d7937b31
https://escholarship.org/uc/item/3rk4d8st
https://escholarship.org/uc/item/3rk4d8st
Publikováno v:
The Journal of Biological Chemistry
Post-translational modification of protein by ubiquitin (Ub) alters the stability, subcellular location, or function of the target protein, thereby impacting numerous biological processes and directly contributing to myriad cellular defects or diseas
Autor:
Lei Fang, Yue Zhao, Chao-Jun Li, Bin Xue, Ruoyu Zhao, Lan Huang, Jingzi Zhang, Clinton Yu, Christine L. N. Bryant, Zhen-Qiang Pan, Zhi-Hong Liu, Kenneth Wu, Yibing Ding
Publikováno v:
J Proteome Res
Journal of proteome research, vol 19, iss 3
Journal of proteome research, vol 19, iss 3
The COP9 signalosome (CSN) is an evolutionarily conserved multisubunit protein complex, which controls protein degradation through deneddylation and inactivation of cullin-RING ubiquitin E3 ligases (CRLs). Recently, the CSN complex has been linked to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66aaebd5ca5c7e05f4e034bfd77e402
https://europepmc.org/articles/PMC7299130/
https://europepmc.org/articles/PMC7299130/
Autor:
Zhen-Qiang Pan
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9789811510243
Adv Exp Med Biol
Adv Exp Med Biol
CRL7(Fbxw8) is an E3 ubiquitin ligase complex, containing cullin7 (CUL7) as a scaffold, the F-box protein Fbxw8 as a substrate receptor, the Skp1 adaptor, and the ROC1/Rbx1 RING finger protein for working with E2 enzyme to facilitate ubiquitin transf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba99834e201114345e93cef7a86e823
https://doi.org/10.1007/978-981-15-1025-0_17
https://doi.org/10.1007/978-981-15-1025-0_17
Autor:
Stephanie Layton, Weihua Zhou, Liu Liu, Zhen-Qiang Pan, Krishnapriya Chinnaswamy, Chao Yie Yang, Jeanne A. Stuckey, Shaomeng Wang, Haibin Zhou, Jianfeng Lu, Denzil Bernard, Ester Fernandez-Salas, Yi Sun, Qing Yu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Nature Communications
The Cullin-RING E3 ubiquitin ligases (CRLs) regulate homeostasis of ~20% of cellular proteins and their activation require neddylation of their cullin subunit. Cullin neddylation is modulated by a scaffolding DCN protein through interactions with bot