Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Zhen-Ke Deng"'
Autor:
Mei Wen, Zhen-ke Deng, Shi-long Jiang, Yi-di Guan, Hai-zhou Wu, Xin-luan Wang, Song-shu Xiao, Yi Zhang, Jin-ming Yang, Dong-sheng Cao, Yan Cheng
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Bcl-2 family protein is an important factor in regulating apoptosis and is associated with cancer. The anti-apoptotic proteins of Bcl-2 family, such as Bcl-2, are overexpression in numerous tumors, and contribute to cancer formation, development, and
Externí odkaz:
https://doaj.org/article/caf8e622526f42f8a8545e011a67fb92
Autor:
Yong-Huan Yun, Wen-Qun Li, Wen-Ling Ye, Alex F. Chen, Jin-Wei Zhang, Su-Qing Yang, Lin Zhang, Liu-Xia Zhang, Dong-Sheng Cao, Zhen-Ke Deng
Publikováno v:
Chemometrics and Intelligent Laboratory Systems. 185:32-40
Heart failure (HF) has become an important social problem that seriously threatens human health due to its high morbidity and mortality. G Protein-Coupled Receptors Kinase 2 (GRK2), as a novel target of heart failure, is overexpressed in the pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ddb37b7f55c2fd339a20f694a1451be
https://doi.org/10.1016/j.chemolab.2018.12.015
https://doi.org/10.1016/j.chemolab.2018.12.015
Autor:
Jie Dong, Chen Huang, Min-Feng Zhu, Aiping Lu, Zhi-Jiang Yao, Ning-Ning Wang, Qi Mi, Alex F. Chen, Dong-Sheng Cao, Zhen-Ke Deng
Publikováno v:
Chemometrics and Intelligent Laboratory Systems. 170:84-95
Plasma protein binding affinity of a drug compound has a strong influence on its pharmacodynamic behavior because it can affect the drug uptake and distribution. In this study, we collected a sizeable dataset consisting of 1830 drug compounds from se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c3d2911fbfa1706ced7e1ffcc658cc5
https://doi.org/10.1016/j.chemolab.2017.09.005
https://doi.org/10.1016/j.chemolab.2017.09.005
Autor:
Chen Huang, Ben Lv, Min-Feng Zhu, Aiping Lu, Jie Dong, Alex F. Chen, Ning-Ning Wang, Dong-Sheng Cao, Zhen-Ke Deng, Zhi-Jiang Yao
Publikováno v:
RSC Advances. 7:19007-19018
With the increase of complexity and risk in drug discovery processes, human intestinal absorption (HIA) prediction has become more and more important. Up to now, some predictive models have been constructed to estimate HIA of new drug-like compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42fb92a6de388eaa676dfcbb08ccaa2e
https://doi.org/10.1039/c6ra28442f
https://doi.org/10.1039/c6ra28442f
Autor:
Jin-Wei Zhang, Defang Ouyang, Dong-Sheng Cao, Zhen-Ke Deng, Yan Cheng, Lu Liu, Qian Cao, Wen-Ling Ye, Lin Zhang, Li Fu, Hui Wei
Publikováno v:
Molecular pharmaceutics. 16(1)
Hepatotoxicity is a major cause of drug withdrawal from the market. To reduce the drug attrition induced by hepatotoxicity, an accurate and efficient hepatotoxicity prediction system must be constructed. In the present study, we constructed a three-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318344f99c41e092322af251cf7aa670
https://pubmed.ncbi.nlm.nih.gov/30475633
https://pubmed.ncbi.nlm.nih.gov/30475633
Publikováno v:
Journal of Chemometrics. 31:e2922
In QSAR/QSPR modeling, building an accurate partial least squares (PLS) model usually involves descriptor selection, outlier detection, applicability domain assessment, nonlinear relationship, and model stability problems. In the present study, we pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c64784cd7604aad2d0c1d52721ae6b58
https://doi.org/10.1002/cem.2922
https://doi.org/10.1002/cem.2922