Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Zhen-Ge Luo"'
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114548- (2024)
Summary: Human cortical neurons (hCNs) exhibit high dendritic complexity and synaptic density, and the maturation process is greatly protracted. However, the molecular mechanism governing these specific features remains unclear. Here, we report that
Externí odkaz:
https://doaj.org/article/af40c18493244602834827addfe0a84e
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114514- (2024)
Summary: The regenerative potential of injured axons displays considerable heterogeneity. However, the molecular mechanisms underlying the heterogeneity have not been fully elucidated. Here, we establish a method that can separate spinal motor neuron
Externí odkaz:
https://doaj.org/article/2c9ce716c69c48ae8ca0627d8599118e
Autor:
Hongyu Chen, Xingchen Liu, Lanxin Li, Qingtong Tan, Shiyan Li, Li Li, Chunyang Li, Jiqiang Fu, Yong Lu, Yan Wang, Yidi Sun, Zhen-Ge Luo, Zongyang Lu, Qiang Sun, Zhen Liu
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract The efficiency of homology-directed repair (HDR) plays a crucial role in the development of animal models and gene therapy. We demonstrate that microhomology-mediated end-joining (MMEJ) constitutes a substantial proportion of DNA repair duri
Externí odkaz:
https://doaj.org/article/d2b7388e9959421b9e75db3577db4141
Autor:
Peibo Xu, Jian Peng, Tingli Yuan, Zhaoqin Chen, Hui He, Ziyan Wu, Ting Li, Xiaodong Li, Luyue Wang, Le Gao, Jun Yan, Wu Wei, Chengyu T Li, Zhen-Ge Luo, Yuejun Chen
Publikováno v:
eLife, Vol 13 (2024)
Deciphering patterns of connectivity between neurons in the brain is a critical step toward understanding brain function. Imaging-based neuroanatomical tracing identifies area-to-area or sparse neuron-to-neuron connectivity patterns, but with limited
Externí odkaz:
https://doaj.org/article/a28cb7507ce64b99a3604793ca736039
Autor:
Xin-Yao Sun, Xiang-Chun Ju, Yang Li, Peng-Ming Zeng, Jian Wu, Ying-Ying Zhou, Li-Bing Shen, Jian Dong, Yue-Jun Chen, Zhen-Ge Luo
Publikováno v:
eLife, Vol 11 (2022)
Brain organoids have been used to recapitulate the processes of brain development and related diseases. However, the lack of vasculatures, which regulate neurogenesis and brain disorders, limits the utility of brain organoids. In this study, we induc
Externí odkaz:
https://doaj.org/article/b811a554852a4f8faceda71a6345dc1e
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109290- (2021)
Summary: Fusion transcripts or RNAs have been found in both disordered and healthy human tissues and cells; however, their physiological functions in the brain development remain unknown. In the analysis of deposited RNA-sequence libraries covering e
Externí odkaz:
https://doaj.org/article/94b8dad432ef4fd79c425aa2a1c70c81
Publikováno v:
Biochemical Society Transactions. 50:1753-1762
The nervous system is composed of a variety of neurons and glial cells with different morphology and functions. In the mammalian peripheral nervous system (PNS) or the lower vertebrate central nervous system (CNS), most neurons can regenerate extensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a979d47bc488400e252271376136564
https://doi.org/10.1042/bst20220624
https://doi.org/10.1042/bst20220624
Publikováno v:
Neuroscience Bulletin.
Understanding the fundamental processes of human brain development and diseases is of great importance for our health. However, existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::627d956ff4e76dee1b9e8ad13dbb4fc3
https://doi.org/10.1007/s12264-023-01065-2
https://doi.org/10.1007/s12264-023-01065-2
Publikováno v:
Journal of Molecular Cell Biology
The prevailing coronavirus disease-19 (COVID-19) caused by a novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has presented some neurological manifestations including hyposmia, hypogeusia, headache, stroke, encephalitis, Guillain–Ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54b928814ea2772d7556ff4e9913ad2
https://doi.org/10.1093/jmcb/mjab044
https://doi.org/10.1093/jmcb/mjab044
Autor:
Xin-Yao Sun, Zhen-Ge Luo
Publikováno v:
Journal of molecular cell biology. 14(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920e41a386a5662b71951397a510913c
https://pubmed.ncbi.nlm.nih.gov/35751626
https://pubmed.ncbi.nlm.nih.gov/35751626