Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Zhen Zhou Yang"'
Publikováno v:
BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background For patients with advanced non-small-cell lung cancer (NSCLC) with EGFR mutations, the suggested course of action is epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). Even with a high disease control rate, a
Externí odkaz:
https://doaj.org/article/30b3d3aa594c4b7d9d427b7e9ce2d92b
Autor:
Hua Jin, Song Luo, Yun Wang, Chang Liu, Zhenghao Piao, Meng Xu, Wei Guan, Qing Li, Hua Zou, Qun-You Tan, Zhen-Zhou Yang, Yan Wang, Dong Wang, Cheng-Xiong Xu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 8, Iss , Pp 111-122 (2017)
Cancer stem cells (CSCs) play an important role in osteosarcoma (OS) metastasis and recurrence, and both Wnt/β-catenin and Notch signaling are essential for the development of the biological traits of CSCs. However, the mechanism that underlies the
Externí odkaz:
https://doaj.org/article/5b68f72969ad4fd7bb689a94d13b6010
Autor:
Meng-Xia Li, Hao He, Zhi-Hua Ruan, Yu-Xi Zhu, Rong-Qing Li, Xiao He, Bao-Hua Lan, Zhi-Min Zhang, Guo-Dong Liu, Hua-Liang Xiao, Yan Wu, Bo Zhu, Ge Wang, Zhen-Zhou Yang
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-8 (2017)
Abstract Background Central nervous system (CNS) brain metastasis of advanced non-small cell lung cancer (NSCLC) patients confers a worse quality of life and prognosis. The efficacy comparison of two first-generation epidermal growth factor receptor
Externí odkaz:
https://doaj.org/article/0bc162c5ca1e4caa8aee00e10ad55199
Publikováno v:
Medicine
Rationale: Transformation to small cell lung cancer (SCLC) is one of the mechanisms of resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). However, no standard treatment is available after the transformation. In add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c12db316198603d3fab5be6cb94c65
http://europepmc.org/articles/PMC8483845
http://europepmc.org/articles/PMC8483845
Publikováno v:
Scientific Reports
Resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) has become the main clinical challenge of advanced lung cancer. This research aimed to explore the role of PARP1-mediated autophagy in the progression of TKI therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e671315a82c3f82bc7f7e26fdfdc2ff
https://pubmed.ncbi.nlm.nih.gov/33262410
https://pubmed.ncbi.nlm.nih.gov/33262410
Publikováno v:
Free Radical Biology and Medicine. 129:310-322
Lonicera japonica (LJ) is widely used as the local medicine to improve body and prevent ills in China, but mechanisms of its healthy beneficial effects remain largely unclear. Here, we evaluated the anti-aging and healthspan promoting activities of 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b982cbb11517be2b35e8e2e44bfb5731
https://doi.org/10.1016/j.freeradbiomed.2018.09.035
https://doi.org/10.1016/j.freeradbiomed.2018.09.035
Publikováno v:
Biochemical and Biophysical Research Communications. 498:751-757
Immunotherapy targeting the programmed cell death-1/programmed death ligand 1(PD-L1) pathway has shown promising antitumor activity in brain metastases (BMs) of non-small cell lung cancer (NSCLC) patients with an acceptable safety profile; however, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c71627bd0d41d5b5fcf853fd563643a9
https://doi.org/10.1016/j.bbrc.2018.03.053
https://doi.org/10.1016/j.bbrc.2018.03.053
Autor:
Hong-Bing Wang, Xiao-Hua Luo, Hong-Ru Lin, Xin-Yan Chen, Zhen-Zhou Yang, Wei Chen, Meng-Lu Sun, Cong-Min Wei
Publikováno v:
Biogerontology. 19:47-65
Cistanche deserticola has been found to exert protection against aging and age-related diseases, but mechanisms underlying its longevity effects remain largely unclear. Here, the multicellular model organism Caenorhabditis elegans was employed to ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e929318ebcabad82c423efd19dcaf84f
https://doi.org/10.1007/s10522-017-9738-0
https://doi.org/10.1007/s10522-017-9738-0
Autor:
Yi Cheng, Nan Dai, Lei Zhang, Xianfeng Lu, Yie Liu, Shiheng Zhang, Xiao Yang, David M. Wilson, Mengxia Li, Dong Wang, Zhen-Zhou Yang, Yuxin Yang
Publikováno v:
Nucleic Acids Research
Base excision repair (BER) handles many forms of endogenous DNA damage, and apurinic/apyrimidinic endonuclease 1 (APE1) is central to this process. Deletion of both alleles of APE1 (a.k.a. Apex1) in mice leads to embryonic lethality, and deficiency i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd0ebb6234367f5905a5fc7a02820c4
https://pubmed.ncbi.nlm.nih.gov/29750271
https://pubmed.ncbi.nlm.nih.gov/29750271