Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Zhen Yuan Lin"'
Autor:
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 6, Pp 719-740 (2024)
Abstract Tumor suppressor p53 (TP53) is frequently mutated in cancer, often resulting not only in loss of its tumor-suppressive function but also acquisition of dominant-negative and even oncogenic gain-of-function traits. While wild-type p53 levels
Externí odkaz:
https://doaj.org/article/4644b709c6d143dfb92c748768749b96
Autor:
Emily H. Xiong, Xiang Zhang, Huijuan Yan, Henry N. Ward, Zhen-Yuan Lin, Cassandra J. Wong, Ci Fu, Anne-Claude Gingras, Suzanne M. Noble, Nicole Robbins, Chad L. Myers, Leah E. Cowen
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114601- (2024)
Summary: Fungal pathogens such as Candida albicans pose a significant threat to human health with limited treatment options available. One strategy to expand the therapeutic target space is to identify genes important for pathogen growth in host-rele
Externí odkaz:
https://doaj.org/article/7a90d14f55eb4540a12239260d52e408
Autor:
Ci Fu, Xiang Zhang, Amanda O. Veri, Kali R. Iyer, Emma Lash, Alice Xue, Huijuan Yan, Nicole M. Revie, Cassandra Wong, Zhen-Yuan Lin, Elizabeth J. Polvi, Sean D. Liston, Benjamin VanderSluis, Jing Hou, Yoko Yashiroda, Anne-Claude Gingras, Charles Boone, Teresa R. O’Meara, Matthew J. O’Meara, Suzanne Noble, Nicole Robbins, Chad L. Myers, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The analysis of essential genes in pathogens can be used to discover potential antimicrobial targets. Here, the authors use a machine learning model and chemogenomic analyses to generate genome-wide gene essentiality predictions for the fungal pathog
Externí odkaz:
https://doaj.org/article/30b53e35a0bc440e930c93cb62d5cbf8
Autor:
Nicole Merritt, Keith Garcia, Dushyandi Rajendran, Zhen-Yuan Lin, Xiaomeng Zhang, Katrina A Mitchell, Nicholas Borcherding, Colleen Fullenkamp, Michael S Chimenti, Anne-Claude Gingras, Kieran F Harvey, Munir R Tanas
Publikováno v:
eLife, Vol 10 (2021)
Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma that metastasizes early in its clinical course and lacks an effective medical therapy. The TAZ-CAMTA1 and YAP-TFE3 fusion proteins are chimeric transcription factors and initiating oncogeni
Externí odkaz:
https://doaj.org/article/f5236ab6208a49dc9d2f318dd8878eee
Autor:
Janer, Alexandre, Morris, Jordan L., Krols, Michiel, Antonicka, Hana, Aaltonen, Mari J., Zhen-Yuan Lin, Anand, Hanish, Gingras, Anne-Claude, Prudent, Julien, Shoubridge, Eric A.
Publikováno v:
Life Science Alliance; Jan2024, Vol. 7 Issue 1, p1-22, 22p
Autor:
Teresa R O'Meara, Matthew J O'Meara, Elizabeth J Polvi, M Reza Pourhaghighi, Sean D Liston, Zhen-Yuan Lin, Amanda O Veri, Andrew Emili, Anne-Claude Gingras, Leah E Cowen
Publikováno v:
PLoS Biology, Vol 17, Iss 7, p e3000358 (2019)
Hsp90 is a conserved molecular chaperone that assists in the folding and function of diverse cellular regulators, with a profound impact on biology, disease, and evolution. As a central hub of protein interaction networks, Hsp90 engages with hundreds
Externí odkaz:
https://doaj.org/article/b7738dbd09824335b714a967c9ef22d6
Autor:
Elizabeth J Polvi, Amanda O Veri, Zhongle Liu, Saif Hossain, Sabrina Hyde, Sang Hu Kim, Faiza Tebbji, Adnane Sellam, Robert T Todd, Jinglin L Xie, Zhen-Yuan Lin, Cassandra J Wong, Rebecca S Shapiro, Malcolm Whiteway, Nicole Robbins, Anne-Claude Gingras, Anna Selmecki, Leah E Cowen
Publikováno v:
PLoS Genetics, Vol 15, Iss 1, p e1007901 (2019)
Morphogenetic transitions are prevalent in the fungal kingdom. For a leading human fungal pathogen, Candida albicans, the capacity to transition between yeast and filaments is key for virulence. For the model yeast Saccharomyces cerevisiae, filamenta
Externí odkaz:
https://doaj.org/article/5f618964eca94d1e8ff2e9f2343fa25a
Autor:
Alexandre Janer, Jordan L. Morris, Michiel Krols, Hana Antonicka, Mari J. Aaltonen, Zhen-Yuan Lin, Anne-Claude Gingras, Julien Prudent, Eric A. Shoubridge
SUMMARYMitochondria interact with the endoplasmic reticulum (ER) at structurally and functionally specialized membrane contact sites known as mitochondria-ER contact sites (MERCs). MERCs are crucial for a myriad of physiological functions including l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b55a63d56edb1c56765c922acd394791
https://doi.org/10.1101/2022.11.14.516495
https://doi.org/10.1101/2022.11.14.516495
Autor:
Yichao Zhao, Daniel Tabet, Diana Rubio Contreras, Arne Nedergaard Kousholt, Jochen Weile, Henrique Melo, Lisa Hoeg, Atina G. Coté, Zhen-Yuan Lin, Dheva Setiaputra, Jos Jonkers, Anne-Claude Gingras, Fernando Gómez Herreros, Frederick P. Roth, Daniel Durocher
To maintain genome integrity, cells must avoid DNA damage by ensuring the accurate duplication of the genome and by having efficient repair and signaling systems that counteract the genome-destabilizing potential of DNA lesions. To uncover genes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb513212c3609e15d8c0b7d8d346e213
https://doi.org/10.1101/2022.09.23.508845
https://doi.org/10.1101/2022.09.23.508845
Autor:
Yiqing Lu, Tiffany Cho, Saptaparna Mukherjee, Ahmad Ammar Malik, Nicolas Gonzalez-Foutel, Carmen Florencia Suarez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid Al-Zahrani, Zhen-Yuan Lin, Ricky Tsai, Varda Rotter, Patricia Ashton-Prolla, Lucia Beatriz Chemes, Jason Moffat, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eb02d2c95bbcfd46a530189d82d5922
https://doi.org/10.15252/rc.2022665859
https://doi.org/10.15252/rc.2022665859