Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Zhen Yong Keck"'
Autor:
Zhen-Yong Keck, Brian G Pierce, Patrick Lau, Janine Lu, Yong Wang, Alexander Underwood, Rowena A Bull, Jannick Prentoe, Rodrigo Velázquez-Moctezuma, Melanie R Walker, Fabio Luciani, Johnathan D Guest, Catherine Fauvelle, Thomas F Baumert, Jens Bukh, Andrew R Lloyd, Steven K H Foung
Publikováno v:
PLoS Pathogens, Vol 15, Iss 5, p e1007772 (2019)
Cumulative evidence supports a role for neutralizing antibodies contributing to spontaneous viral clearance during acute hepatitis C virus (HCV) infection. Information on the timing and specificity of the B cell response associated with clearance is
Externí odkaz:
https://doaj.org/article/02ca33a0a5d144a7a284f9c9f72f99b4
Autor:
Katie A. Howell, Xiangguo Qiu, Jennifer M. Brannan, Christopher Bryan, Edgar Davidson, Frederick W. Holtsberg, Anna Z. Wec, Sergey Shulenin, Julia E. Biggins, Robin Douglas, Sven G. Enterlein, Hannah L. Turner, Jesper Pallesen, Charles D. Murin, Shihua He, Andrea Kroeker, Hong Vu, Andrew S. Herbert, Marnie L. Fusco, Elisabeth K. Nyakatura, Jonathan R. Lai, Zhen-Yong Keck, Steven K.H. Foung, Erica Ollmann Saphire, Larry Zeitlin, Andrew B. Ward, Kartik Chandran, Benjamin J. Doranz, Gary P. Kobinger, John M. Dye, M. Javad Aman
Publikováno v:
Cell Reports, Vol 15, Iss 7, Pp 1514-1526 (2016)
Summary: Previous efforts to identify cross-neutralizing antibodies to the receptor-binding site (RBS) of ebolavirus glycoproteins have been unsuccessful, largely because the RBS is occluded on the viral surface. We report a monoclonal antibody (FVM0
Externí odkaz:
https://doaj.org/article/8cb2b4542b0546a695db88b408e10d26
Autor:
Marian E. Major, Nicole Frumento, Alexander W. Tarr, Johnathan D. Guest, Steven K. H. Foung, Arvind H. Patel, Alexis Figueroa, Jordan Salas, Jonathan K. Ball, Vanessa M. Cowton, Kaitlyn E. Clark, Heidi E. Drummer, Thomas R. Fuerst, Richard A. Urbanowicz, Sarah Cole, Brian G. Pierce, Zhen-Yong Keck, Mansun Law, Justin R. Bailey
Publikováno v:
Gastroenterology. 162:562-574
Background and Aims Development of a prophylactic hepatitis C virus (HCV) vaccine will require accurate and reproducible measurement of neutralizing breadth of vaccine-induced antibodies. Currently available HCV panels may not adequately represent th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970267ca7d83f618757fb8d31409310c
https://doi.org/10.1053/j.gastro.2021.10.005
https://doi.org/10.1053/j.gastro.2021.10.005
Autor:
Florian Wrensch, Emilie Crouchet, Gaetan Ligat, Mirjam B. Zeisel, Zhen-Yong Keck, Steven K. H. Foung, Catherine Schuster, Thomas F. Baumert
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
With more than 71 million people chronically infected, hepatitis C virus (HCV) is one of the leading causes of liver disease and hepatocellular carcinoma. While efficient antiviral therapies have entered clinical standard of care, the development of
Externí odkaz:
https://doaj.org/article/89e24b5529904263880055316701d415
Publikováno v:
Frontiers in Microbiology, Vol 8 (2018)
The ability to use structure-based design and engineering to control the molecular shape and reactivity of an immunogen to induce protective responses shows great promise, along with corresponding advancements in vaccine testing and evaluation system
Externí odkaz:
https://doaj.org/article/d1aa7b6b5f1a43c0aeb51fc445389cf5
Autor:
Ruixue Wang, Saori Suzuki, Johnathan D. Guest, Brigitte Heller, Maricar Almeda, Alexander K. Andrianov, Alexander Marin, Roy A. Mariuzza, Zhen-Yong Keck, Steven K. H. Foung, Abdul S. Yunus, Brian G. Pierce, Eric A. Toth, Alexander Ploss, Thomas R. Fuerst
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(11)
Significance Hepatitis C virus chronically infects approximately 1% of the world’s population, making an effective vaccine for hepatitis C virus a major unmet public health need. The membrane-associated E1E2 envelope glycoprotein has been used in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f97e63f66015ca70c9be173f67cdcc
https://pubmed.ncbi.nlm.nih.gov/35263223
https://pubmed.ncbi.nlm.nih.gov/35263223
Publikováno v:
Viruses, Vol 3, Iss 11, Pp 2127-2145 (2011)
A critical first step in a “rational vaccine design” approach for hepatitis C virus (HCV) is to identify the most relevant mechanisms of immune protection. Emerging evidence provides support for a protective role of virus neutralizing antibodies,
Externí odkaz:
https://doaj.org/article/ecac56afae5f4501b0cf0bf865761191
Autor:
Zhen-yong Keck, Allan G N Angus, Wenyan Wang, Patrick Lau, Yong Wang, Derek Gatherer, Arvind H Patel, Steven K H Foung
Publikováno v:
PLoS Pathogens, Vol 10, Iss 8, p e1004297 (2014)
A challenge for hepatitis C virus (HCV) vaccine development is to define epitopes that are able to elicit protective antibodies against this highly diverse virus. The E2 glycoprotein region located at residues 412-423 is conserved and antibodies to 4
Externí odkaz:
https://doaj.org/article/a9bb5eb1ccdf44dc99201ffff062dbad
Publikováno v:
Curr Opin Virol
The molecular mechanisms of hepatitis C virus (HCV) persistence and pathogenesis are poorly understood. The design of an effective HCV vaccine is challenging despite a robust humoral immune response against closely related strains of HCV. This is pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c9a76fc99ac11c1567899a4d1564c3
https://pubmed.ncbi.nlm.nih.gov/34091143
https://pubmed.ncbi.nlm.nih.gov/34091143
Autor:
Alexander K. Andrianov, Ruixue Wang, Roy A. Mariuzza, Steven K. H. Foung, Andrezza Chagas, Thomas E. Cleveland, Young Chang Kim, Abdul S. Yunus, Zhen-Yong Keck, Alexander Marin, Thomas R. Fuerst, Kinlin L. Chao, Johnathan D. Guest, Eric A. Toth, Brian G. Pierce, Khadija Elkholy
Publikováno v:
Proc Natl Acad Sci U S A
Hepatitis C virus (HCV) is a major worldwide health burden, and a preventive vaccine is needed for global control or eradication of this virus. A substantial hurdle to an effective HCV vaccine is the high variability of the virus, leading to immune e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe760342749e3d6c9b7f0db94fc3a9c1
https://doi.org/10.1073/pnas.2015149118
https://doi.org/10.1073/pnas.2015149118