Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Zhen Xuan Yeo"'
Autor:
Wing Chan, Mianne Lee, Zhen Xuan Yeo, Dingge Ying, Keith A. Grimaldi, Craig Pickering, Michael M. S. Yang, Senthil K. Sundaram, Lawrence C. H. Tzang
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 18, Iss 1, Pp 1-8 (2020)
Abstract Background Understanding the genetic basis of cancer risk is a major international endeavor. The emergence of next-generation sequencing (NGS) in late 2000’s has further accelerated the discovery of many cancer susceptibility genes. The us
Externí odkaz:
https://doaj.org/article/5fbb086b5cdc433cadb931c41fb52625
Autor:
Mianne Lee, Keith A. Grimaldi, Zhen Xuan Yeo, Michael M. S. Yang, Senthil K. Sundaram, Wing Chan, Craig Pickering, Dingge Ying, Lawrence C. H. Tzang
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 18, Iss 1, Pp 1-8 (2020)
Hereditary Cancer in Clinical Practice
Hereditary Cancer in Clinical Practice
Background Understanding the genetic basis of cancer risk is a major international endeavor. The emergence of next-generation sequencing (NGS) in late 2000’s has further accelerated the discovery of many cancer susceptibility genes. The use of targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a3f1788cdd4943a0e39d649d49eac8
http://link.springer.com/article/10.1186/s13053-020-00141-2
http://link.springer.com/article/10.1186/s13053-020-00141-2
Autor:
Sandhya Shekar, Zhen Xuan Yeo, Joshua C L Wong, Maurice K L Chan, Danny C T Ong, Pumipat Tongyoo, Sin-Yew Wong, Ann S G Lee
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102383 (2014)
Isoniazid (INH) is a highly effective antibiotic central for the treatment of Mycobacterium tuberculosis (MTB). INH-resistant MTB clinical isolates are frequently mutated in the katG gene and the inhA promoter region, but 10 to 37% of INH-resistant c
Externí odkaz:
https://doaj.org/article/c908b2547b3947159af9f1d32e7e5762
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45798 (2012)
The emergence of benchtop sequencers has made clinical genetic testing using next-generation sequencing more feasible. Ion Torrent's PGM™ is one such benchtop sequencer that shows clinical promise in detecting single nucleotide variations (SNVs) an
Externí odkaz:
https://doaj.org/article/c6ae002a895d448296f7d1d3ccb52186
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 12, p e1002798 (2012)
Precise patterns of spatial and temporal gene expression are central to metazoan complexity and act as a driving force for embryonic development. While there has been substantial progress in dissecting and predicting cis-regulatory activity, our unde
Externí odkaz:
https://doaj.org/article/d55b710cf9d741bc95a0d40cc962f513
Autor:
Zhen Xuan Yeo1 zhenxuan_yeo@hotmail.com, Joshua Chee Wong1 joswg@yahoo.com, Rozen, Steven G.2 steve.rozen@duke-nus.edu.sg, Lee, Ann Siew1,3,4 dmslsg@nccs.com.sg
Publikováno v:
BMC Genomics. 2014, Vol. 15 Issue 1, p1-20. 20p.
Autor:
Zhen Xuan Yeo, Sum Thai Wong, Satya Nanda Vel Arjunan, Vincent Piras, Masaru Tomita, Kumar Selvarajoo, Alessandro Giuliani, Masa Tsuchiya
Publikováno v:
PLoS ONE, Vol 2, Iss 8, p e776 (2007)
BACKGROUND: Cellular signaling involves a sequence of events from ligand binding to membrane receptors through transcription factors activation and the induction of mRNA expression. The transcriptional-regulatory system plays a pivotal role in the co
Externí odkaz:
https://doaj.org/article/e5daef35b4eb4eb49ae2687ff4f04f6d
Autor:
Suzanne Brewerton, Ken Bloom, Zhen Xuan Yeo, Amalio Telenti, Jason Piper, J. Craig Venter, Tao Long, Richard H. Scheuermann, Chao Xie, Colleen Brady, Stephen R. Spellman, William H. Biggs, Sally Howard, Ewen F. Kirkness, Marie Wong, Cynthia Vierra-Green, Yaron Turpaz
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 30
Significance Regulation of the human immune system is largely controlled by the HLA gene complex on chromosome 6 and is important in infectious disease immunity, graft rejection, autoimmunity, and cancer. HLA typing is traditionally performed by sero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68e8fd941ea01526211c63a90a33a8f
https://doi.org/10.1073/pnas.1707945114
https://doi.org/10.1073/pnas.1707945114
Autor:
Maurice Chan, Shen Mo Ji, Zhen Xuan Yeo, Linda Gan, Eric Yap, Yoon Sim Yap, Raymond Ng, Puay Hoon Tan, Gay Hui Ho, Peter Ang, Ann Siew Gek Lee
Publikováno v:
The Journal of Molecular Diagnostics. 14:602-612
In a clinical setting, next-generation sequencing (NGS) approaches for the enrichment and resequencing of DNA targets may have limitations in throughput, cost, or accuracy. We evaluated an NGS workflow for targeted DNA sequencing for mutation detecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6d685c2e40aba920086d1a8e6ce0ef8
https://doi.org/10.1016/j.jmoldx.2012.06.003
https://doi.org/10.1016/j.jmoldx.2012.06.003
Publikováno v:
BMC Genomics
Background The Ion Torrent PGM is a popular benchtop sequencer that shows promise in replacing conventional Sanger sequencing as the gold standard for mutation detection. Despite the PGM’s reported high accuracy in calling single nucleotide variati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e2ff64941acc55ee12d9a5c973af91
https://pubmed.ncbi.nlm.nih.gov/24962530
https://pubmed.ncbi.nlm.nih.gov/24962530