Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Zhen Wah Tan"'
Publikováno v:
Current Research in Structural Biology, Vol 7, Iss , Pp 100129- (2024)
Since nucleic acids and proteins of unicellular prokaryotes are directly exposed to extreme environmental conditions, it is possible to explore the genomic-proteomic compositional determinants of molecular mechanisms of adaptation developed by them i
Externí odkaz:
https://doaj.org/article/f6b4dd65a97543b2b6ad6d8273b19add
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract We tackle here genomic mechanisms of a rapid onset and recovery from anosmia—a potential diagnostic indicator for early-stage COVID-19 infection. Based on previous observations on how olfactory receptor (OR) gene expression is regulated vi
Externí odkaz:
https://doaj.org/article/ac08d6ea144646a3b93ae2cb6a35f5fb
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 12, p e1006686 (2018)
We propose a new computational method for exploring chromatin structural organization based on Markov State Modelling of Hi-C data represented as an interaction network between genomic loci. A Markov process describes the random walk of a traveling p
Externí odkaz:
https://doaj.org/article/bc70ba955f9e48409c54544a03897131
Publikováno v:
Nucleic Acids Research. 51:D345-D351
AlloMAPS 2 is an update of the Allosteric Mutation Analysis and Polymorphism of Signalling database, which contains data on allosteric communication obtained for predicted structures in the AlphaFold database (AFDB) and trRosetta-predicted Pfam domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda8eaca1dba333c381e7b35f6180a14
https://doi.org/10.1093/nar/gkac828
https://doi.org/10.1093/nar/gkac828
We tackle here genomic mechanisms of a rapid onset and recovery from anosmia - a useful diagnostic indicator for early-stage COVID-19 infection. On the basis of earlier observed specifics of olfactory receptors (ORs) regulation in the mice chromatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db9e270fe7f597602fa312798d818e35
https://doi.org/10.1101/2022.08.19.504545
https://doi.org/10.1101/2022.08.19.504545
Publikováno v:
The Journal of Physical Chemistry B. 125:3763-3780
While the pervasiveness of allostery in proteins is commonly accepted, we further show the generic nature of allosteric mechanisms by analyzing here transmembrane ion-channel viroporin 3a and RNA-dependent RNA polymerase (RdRp) from SARS-CoV-2 along
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06faa607b0ebeaa7ced1e499ff6ff5f9
https://doi.org/10.1021/acs.jpcb.1c00540
https://doi.org/10.1021/acs.jpcb.1c00540
Autor:
Firdaus Samsudin, Wei-Ven Tee, Igor N. Berezovsky, Peter J. Bond, Enrico Guarnera, Zhen Wah Tan
Publikováno v:
Structure (London, England : 1993)
Recent developments in the SARS-CoV-2 pandemic point to its inevitable transformation into an endemic disease, urging both refinement of diagnostics for emerging variants of concern (VOCs) and design of variant-specific drugs in addition to vaccine a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0dc99da91269aac7cb4198966aa9aae
http://europepmc.org/articles/PMC8772014
http://europepmc.org/articles/PMC8772014
Publikováno v:
Biophysical Journal. 122:51a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5bc6737f0225834a2637fa07e7ac08b
https://doi.org/10.1016/j.bpj.2022.11.487
https://doi.org/10.1016/j.bpj.2022.11.487
Publikováno v:
Biophysical Journal. 122:469a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86d4c9411e4070fab817640d8e0deac0
https://doi.org/10.1016/j.bpj.2022.11.2513
https://doi.org/10.1016/j.bpj.2022.11.2513
Publikováno v:
Journal of Molecular Biology. 434:167577
Hand-in-hand work of physics and evolution delivered protein universe with diversity of forms, sizes, and functions. Pervasiveness and advantageous traits of allostery made it an important component of the protein function regulation, calling for tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1047eba90580560f7f9d17ce948d9ae
https://doi.org/10.1016/j.jmb.2022.167577
https://doi.org/10.1016/j.jmb.2022.167577