Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Zhen Guo Ma"'
Autor:
Zhen-Guo Ma, Yu-Pei Yuan, Di Fan, Xin Zhang, Teng Teng, Peng Song, Chun-Yan Kong, Can Hu, Wen-Ying Wei, Qi-Zhu Tang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Cardiac fibrosis is a common feature of chronic heart failure. Iroquois homeobox (IRX) family of transcription factors plays important roles in heart development; however, the role of IRX2 in cardiac fibrosis has not been clarified. Here we
Externí odkaz:
https://doaj.org/article/1ab3daa42e654c67a74debdbbfdb53e3
Autor:
Xin Zhang, Can Hu, Zhen-Guo Ma, Min Hu, Xiao-Pin Yuan, Yu-Pei Yuan, Sha-Sha Wang, Chun-Yan Kong, Teng Teng, Qi-Zhu Tang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The hexosamine biosynthetic pathway (HBP) produces uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) to facilitate O-linked GlcNAc (O-GlcNAc) protein modifications, and subsequently enhance cell survival under lethal stresses. Transcript
Externí odkaz:
https://doaj.org/article/2783571945d74f9e96742f835e7dbbe6
Autor:
Yang Mu, Ling-Bo Luo, Rong Huang, Zhuo-Yu Shen, Dan Huang, Shu-Hong Zhao, Jing Yang, Zhen-Guo Ma
Publikováno v:
Clinical Science; Nov2024, Vol. 138 Issue 21, p1421-1440, 20p
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
ObjectiveFerroptosis is a unique cell death depended on iron metabolism disorder which is different from previous apoptosis-regulated cell death. Early studies have proposed that ferroptosis is closely associated with multiple cardiovascular diseases
Externí odkaz:
https://doaj.org/article/1f4e420a21544199aac0bfc1ead61dd2
Autor:
Xin Zhang, Can Hu, Xiao-Pin Yuan, Yu-Pei Yuan, Peng Song, Chun-Yan Kong, Teng Teng, Min Hu, Si-Chi Xu, Zhen-Guo Ma, Qi-Zhu Tang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-12 (2021)
Abstract Proteasomal activity is compromised in diabetic hearts that contributes to proteotoxic stresses and cardiac dysfunction. Osteocrin (OSTN) acts as a novel exercise-responsive myokine and is implicated in various cardiac diseases. Herein, we a
Externí odkaz:
https://doaj.org/article/f9ab1ac8fc894b75b13dcf79b126c115
Autor:
Can Hu, Xin Zhang, Peng Song, Yu-Pei Yuan, Chun-Yan Kong, Hai-Ming Wu, Si-Chi Xu, Zhen-Guo Ma, Qi-Zhu Tang
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101747- (2020)
Meteorin-like (METRNL) protein is a newly identified myokine that functions to modulate energy expenditure and inflammation in adipose tissue. Herein, we aim to investigate the potential role and molecular basis of METRNL in doxorubicin (DOX)-induced
Externí odkaz:
https://doaj.org/article/2e39f6171bdc488bbff1fb7aaa07218a
Publikováno v:
Clinical and Translational Medicine, Vol 10, Iss 3, Pp n/a-n/a (2020)
Abstract Background Inflammation, oxidative stress, and apoptosis contribute to the evolution of doxorubicin (DOX)‐induced cardiotoxicity. Osteocrin (OSTN) is a novel secretory peptide mainly derived from the bone and skeletal muscle, and plays cri
Externí odkaz:
https://doaj.org/article/0f072cbbbf624989a2e281fa9dc86425
Autor:
Wen-Ying Wei, Ning Zhang, Ling-Li Li, Zhen-Guo Ma, Man Xu, Yu-Pei Yuan, Wei Deng, Qi-Zhu Tang
Publikováno v:
Cellular Physiology and Biochemistry, Vol 45, Iss 1, Pp 26-36 (2017)
Background/Aims: Cardiac fibrosis, characterized by an unbalanced production and degradation of extracellular matrix components, is a common pathophysiology of multiple cardiovascular diseases. Recent studies suggested that endothelial to mesenchymal
Externí odkaz:
https://doaj.org/article/cd1a7043cbc54775aa3a524ce36ef8b2
Publikováno v:
EBioMedicine, Vol 18, Iss C, Pp 179-187 (2017)
Mitogen-activated protein kinases (MAPKs) and AMPactivated protein kinase α (AMPKα) play critical roles in the process of cardiac hypertrophy. Previous studies have demonstrated that piperine activates AMPKα and reduces the phosphorylation of ex
Externí odkaz:
https://doaj.org/article/99d9d1ea10d14758a60f552082ce5b7b
Autor:
Ning Li, Heng Zhou, Zhen-Guo Ma, Jin-Xiu Zhu, Chen Liu, Peng Song, Chun-Yan Kong, Hai-Ming Wu, Wei Deng, Qi-Zhu Tang
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Objective: Geniposide (GE) is a major component in the fruit of Gardenia jasminoides Ellis. Oxidative stress, endoplasmic reticulum (ER) stress, and canonical Smad3 pathway are implicated in the pathogenesis of cardiac fibrosis. We aim to investigate
Externí odkaz:
https://doaj.org/article/1aed4785a0e64a39957b86b45fd882e7