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Akademický článek

A broadly applicable protein-polymer adjuvant system for antiviral vaccines

Autor: Caiqian Wang, Yuanyuan Geng, Haoran Wang, Zeheng Ren, Qingxiu Hou, An Fang, Qiong Wu, Liqin Wu, Xiujuan Shi, Ming Zhou, Zhen F Fu, Jonathan F Lovell, Honglin Jin, Ling Zhao

Publikováno v: EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1451-1483 (2024)

Abstract Although protein subunit vaccines generally have acceptable safety profiles with precise antigenic content, limited immunogenicity can lead to unsatisfactory humoral and cellular immunity and the need for vaccine adjuvants and delivery syste

Externí odkaz: https://doaj.org/article/a34d3dfc3d324d818a21353b94f3adc5

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Akademický článek

λ-Carrageenan P32 Is a Potent Inhibitor of Rabies Virus Infection.

Autor: Zhaochen Luo, Dayong Tian, Ming Zhou, Wenjie Xiao, Yachun Zhang, Mingming Li, Baokun Sui, Wei Wang, Huashi Guan, Huanchun Chen, Zhen F Fu, Ling Zhao

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0140586 (2015)

Rabies, caused by rabies virus (RABV), is an acute, fatal encephalitic disease that affects many warm-blooded mammals. Currently, post-exposure prophylaxis regimens are effective for most rabies cases, but once the clinical signs of the disease appea

Externí odkaz: https://doaj.org/article/ad5ef84021c24996b613b9278b39ef4c

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Akademický článek

Differential Host Immune Responses after Infection with Wild-Type or Lab-Attenuated Rabies Viruses in Dogs.

Autor: Clement W Gnanadurai, Yang Yang, Ying Huang, Zhenguang Li, Christina M Leyson, Tanya L Cooper, Simon R Platt, Stephen B Harvey, Douglas C Hooper, Milosz Faber, Zhen F Fu

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 8, p e0004023 (2015)

METHODOLOGY/PRINCIPAL FINDINGS:The experimental infection of dogs with TriGAS induced high levels of VNA in the serum, whereas wt RABV infection did not. Dogs infected with TriGAS developed antibodies against the virus including its glycoprotein, whe

Externí odkaz: https://doaj.org/article/d57e5110474d4cc09507b32dd391ed1c

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Akademický článek

A recombinant rabies virus encoding two copies of the glycoprotein gene confers protection in dogs against a virulent challenge.

Autor: Xiaohui Liu, Youtian Yang, Zhaojin Sun, Jing Chen, Jun Ai, Can Dun, Zhen F Fu, Xuefeng Niu, Xiaofeng Guo

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e87105 (2014)

The rabies virus (RABV) glycoprotein (G) is the principal antigen responsible for the induction of virus neutralizing antibodies (VNA) and is the major modality of protective immunity in animals. A recombinant RABV HEP-Flury strain was generated by r

Externí odkaz: https://doaj.org/article/bf12e049554144409eac1bb180978de9

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Akademický článek

Presence of virus neutralizing antibodies in cerebral spinal fluid correlates with non-lethal rabies in dogs.

Autor: Clement W Gnanadurai, Ming Zhou, Wenqi He, Christina M Leyson, Chien-Tsun Huang, Gregory Salyards, Stephen B Harvey, Zhenhai Chen, Biao He, Yang Yang, D C Hooper, Berhnard Dietzchold, Zhen F Fu

Publikováno v: PLoS Neglected Tropical Diseases, Vol 7, Iss 9, p e2375 (2013)

Rabies is traditionally considered a uniformly fatal disease after onset of clinical manifestations. However, increasing evidence indicates that non-lethal infection as well as recovery from flaccid paralysis and encephalitis occurs in laboratory ani

Externí odkaz: https://doaj.org/article/bb2a88df811948c59f660ce416db4bff

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Akademický článek

Recombinant rabies viruses expressing GM-CSF or flagellin are effective vaccines for both intramuscular and oral immunizations.

Autor: Ming Zhou, Guoqing Zhang, Guiping Ren, Clement W Gnanadurai, Zhenguang Li, Qingqing Chai, Yang Yang, Christina M Leyson, Wenxue Wu, Min Cui, Zhen F Fu

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63384 (2013)

Our previous studies indicated that recombinant rabies viruses (rRABV) expressing chemokines or cytokines (including GM-CSF) could enhance the immunogenicity by recruiting and/or activating dendritic cells (DC). In this study, bacterial flagellin was

Externí odkaz: https://doaj.org/article/d8e090c61c2648ac92bb2b0b18d427e4

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Akademický článek

Evaluating a parainfluenza virus 5-based vaccine in a host with pre-existing immunity against parainfluenza virus 5.

Autor: Zhenhai Chen, Pei Xu, Gregory W Salyards, Stephen B Harvey, Balazs Rada, Zhen F Fu, Biao He

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e50144 (2012)

Parainfluenza virus 5 (PIV5), formerly known as simian virus 5 (SV5), is a paramyxovirus often referred to as canine parainfluenza virus (CPI) in the veterinary field. PIV5 is thought to be a contributing factor to kennel cough. Kennel cough vaccines

Externí odkaz: https://doaj.org/article/d6aa78a0527e4ba194328d6f813c996b

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Akademický článek

Intracerebral administration of recombinant rabies virus expressing GM-CSF prevents the development of rabies after infection with street virus.

Autor: Hualei Wang, Guoqing Zhang, Yongjun Wen, Songtao Yang, Xianzhu Xia, Zhen F Fu

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e25414 (2011)

Recently it was found that prior immunization with recombinant rabies virus (RABV) expressing granulocyte-macrophage colony-stimulating factor (GM-CSF) (LBNSE-GM-CSF) resulted in high innate/adaptive immune responses and protection against challenge

Externí odkaz: https://doaj.org/article/9fad44fc9b444f969c94652b1455bf10

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