Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Zhen‐Ning Zhang"'
Autor:
Xuejuan Zhu, Xinran Wang, Jingang Wang, Lei Du, Zhen‐Ning Zhang, Donglei Zhou, Junfeng Han, Bing Luan
Publikováno v:
Advanced Science, Vol 11, Iss 42, Pp n/a-n/a (2024)
Abstract Intermittent fasting (IF) plays a critical role in mitigating obesity, yet the precise biological mechanisms require further elucidation. Here Orosomucoid 2 (Orm2) is identified as an IF‐induced hepatokine that stimulates adipose browning.
Externí odkaz:
https://doaj.org/article/1235c7c016954749baf8e6df356c41e6
Autor:
Mengting Gong, Yulin Fang, Kaijiang Yang, Fei Yuan, Rui Hu, Yajuan Su, Yiling Yang, Wenjun Xu, Qing Ma, Jiaxue Cha, Ru Zhang, Zhen‐Ning Zhang, Weida Li
Publikováno v:
Advanced Science, Vol 11, Iss 41, Pp n/a-n/a (2024)
Abstract Obesity, a growing global health concern, is closely linked to depression. However, the neural mechanism of association between obesity and depression remains poorly understood. In this study, neural‐specific WFS1 deficiency exacerbates th
Externí odkaz:
https://doaj.org/article/7f82db8142a3446586146e23f15dfeec
Autor:
Qing Ma, Yini Xiao, Wenjun Xu, Menghan Wang, Sheng Li, Zhihao Yang, Minglu Xu, Tengjiao Zhang, Zhen-Ning Zhang, Rui Hu, Qiang Su, Fei Yuan, Tinghui Xiao, Xuan Wang, Qing He, Jiaxu Zhao, Zheng-jun Chen, Zhejin Sheng, Mengyao Chai, Hong Wang, Weiyang Shi, Qiaolin Deng, Xin Cheng, Weida Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Immature function and fragility hinder application of hESC-derived β cells (SC-β cell) for diabetes cell therapy. Here, the authors identify ZnT8 as a gene editing target to enhance the insulin secretion and cell survival under metabolic stress by
Externí odkaz:
https://doaj.org/article/498f4e26b64740c4ac0e64e6b7a3344f
Autor:
Shaojian Lin, Anke Zhang, Ling Yuan, Yufan Wang, Chuan Zhang, Junkun Jiang, Houshi Xu, Huiwen Yuan, Hui Yao, Qianying Zhang, Yong Zhang, Meiqing Lou, Ping Wang, Zhen-Ning Zhang, Bing Luan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Exercise increases energy expenditure and suppresses obesity, but the effector mechanisms are not still unclear. Here the authors profile serum proteomics in exercised mice to find reduced parvalbumin levels that correlate with increased M2 macrophag
Externí odkaz:
https://doaj.org/article/0aee7fe940574361ba439b882168a9bc
Autor:
Miao-Qing Wang, You-Zeng Hao, Zhen-Ning Zhang, Bin Zhang, Yue-De Yang, Jin-Long Xiao, António L. Teixeira, Yong-Zhen Huang
Publikováno v:
Photonics, Vol 9, Iss 11, p 827 (2022)
In this work, we investigate an alternative directly modulated laser solution with applications to multiwavelength 25 Gb/s systems. The presented solution is based on a hybrid square/rhombus-rectangular laser (HSRRL), which consists of a Fabry–Pér
Externí odkaz:
https://doaj.org/article/7a72de6787504b80a93f507f1d05f6fb
Autor:
Zhen-Ning Zhang, Hai Liu, Mi-Mi Liu, Dan-Lei Yang, Jue Bi, Qian-Qian Chen, Wei Chen, Ping Xiang
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1283 (2022)
Nickel (Ni) is ubiquitous in the environment and evidence has suggested that Ni can cause ocular surface inflammation, especially in fine particulate matter and personal products. Continuous daily exposure to Ni-containing dust may adversely impact t
Externí odkaz:
https://doaj.org/article/0defaf8161b84ad288ca1047a496c8c9
Autor:
Jian Li, Sihan Lv, Xinchen Qiu, Jiamin Yu, Junkun Jiang, Yalan Jin, Wenxuan Guo, Ruowei Zhao, Zhen-Ning Zhang, Chao Zhang, Bing Luan
Publikováno v:
Protein & Cell, Vol 9, Iss 11, Pp 976-980 (2018)
Externí odkaz:
https://doaj.org/article/8d62129af7ab4871a40f32858bd77184
Autor:
Xinchen Qiu, Jian Li, Sihan Lv, Jiamin Yu, Junkun Jiang, Jindong Yao, Yang Xiao, Bingxin Xu, Haiyan He, Fangfei Guo, Zhen-Ning Zhang, Chao Zhang, Bing Luan
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 2, Pp 330-338 (2018)
Disregulation of fatty acid oxidation, one of the major mechanisms for maintaining hepatic lipid homeostasis under fasting conditions, leads to hepatic steatosis. Although obesity and type 2 diabetes-induced endoplasmic reticulum (ER) stress contribu
Externí odkaz:
https://doaj.org/article/74e4638e3fe049fdad55ed80bc7d940a
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
In the brain, the serotonergic neurons located in the raphe nucleus are the unique resource of the neurotransmitter serotonin, which plays a pivotal role in the regulation of brain development and functions. Dysfunction of the serotonin system is pre
Externí odkaz:
https://doaj.org/article/3a104b544b504e0d952b2290c46fb015
Autor:
Zhe Li, Hongxia Lu, Weifeng Yang, Jun Yong, Zhen-ning Zhang, Kun Zhang, Hongkui Deng, Yang Xu
Publikováno v:
Stem Cell Reports, Vol 2, Iss 4, Pp 399-405 (2014)
Ectopic expression of reprogramming factors has been widely adopted to reprogram somatic nucleus into a pluripotent state (induced pluripotent stem cells [iPSCs]). However, genetic aberrations such as somatic gene mutation in the resulting iPSCs have
Externí odkaz:
https://doaj.org/article/60d6df0afdf54921b7e2e05d38553d39