Vitamin D Receptor Mediates a Myriad of Biological Actions Dependent on Its 1,25‐Dihydroxyvitamin D Ligand: Distinct Regulatory Themes Revealed by Induction of Klotho and Fibroblast Growth Factor‐23

Autor: Mark R Haussler, Sarah Livingston, Zhela L Sabir, Carol A Haussler, Peter W Jurutka

Publikováno v: JBMR Plus, Vol 5, Iss 1, Pp n/a-n/a (2021)

ABSTRACT The hormonal vitamin D metabolite, 1,25‐dihydroxyvitamin D [1,25(OH)2D], produced in kidney, acts in numerous end organs via the nuclear vitamin D receptor (VDR) to trigger molecular events that orchestrate bone mineral homeostasis. VDR is

Externí odkaz: https://doaj.org/article/c7425342a9a941979042901e2ad20917

Development of Novel Bexarotene Analogs for Treating Cutaneous T‐Cell Lymphomas

Autor: Carl E. Wagner, Zhela L. Sabir, Lech Staniszewski, Pamela A. Marshall, Ankedo Warda, Eyal Ron, Peter W. Jurutka

Publikováno v: The FASEB Journal. 35

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67bf849b738e14bcd56c9d4a6a347083
https://doi.org/10.1096/fasebj.2021.35.s1.04737

Vitamin D Receptor Mediates a Myriad of Biological Actions Dependent on Its 1,25‐Dihydroxyvitamin D Ligand: Distinct Regulatory Themes Revealed by Induction of Klotho and Fibroblast Growth Factor‐23

Autor: Peter W. Jurutka, Zhela L. Sabir, Carol A. Haussler, Mark R. Haussler, Sarah Livingston

Publikováno v: JBMR Plus, Vol 5, Iss 1, Pp n/a-n/a (2021)
JBMR Plus

The hormonal vitamin D metabolite, 1,25‐dihydroxyvitamin D [1,25(OH)2D], produced in kidney, acts in numerous end organs via the nuclear vitamin D receptor (VDR) to trigger molecular events that orchestrate bone mineral homeostasis. VDR is a ligand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9f546650404b70b1444fe8475c3b72
https://doaj.org/article/c7425342a9a941979042901e2ad20917

Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB)

Autor: Peter W. Jurutka, Stephanie L. Suban, John S. Welch, Ankedo Warda, Dena Haddad, Wei Liu, San Raban, Jesse Davidson, Lech J. P. Staniszewski, Ani Minasian, Madleen Khamisi, Sabeeha Mushtaq Reshi, Samir J. Ibrahim, Pamela A. Marshall, Riley Candia, Sanchita Mallick, Joseph W. Ziller, Chang Liu, Ming-Yue Lee, Emma L. Maiorella, Carl E. Wagner, Bradley J. Dawson, Orsola di Martino, Zhela L. Sabir

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 12371, p 12371 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 22

Five novel analogs of 6-(ethyl)(4-isobutoxy-3-isopropylphenyl)amino)nicotinic acid—or NEt-4IB—in addition to seven novel analogs of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) were prepared and eval

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025e2ac8b5b2b202f7ed5775f75174f5
https://doi.org/10.3390/ijms222212371

Pomegranate derivative urolithin A enhances vitamin D receptor signaling to amplify serotonin-related gene induction by 1,25-dihydroxyvitamin D

Autor: Sarah Livingston, Sanchita Mallick, Daniel A. Lucas, Marya S. Sabir, Zhela L. Sabir, Hespera Purdin, Sree Nidamanuri, Carol A. Haussler, Mark R. Haussler, Peter W. Jurutka

Publikováno v: Biochemistry and Biophysics Reports, Vol 24, Iss , Pp 100825- (2020)

Mediated by the nuclear vitamin D receptor (VDR), the hormonally active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (1,25D), is known to regulate expression of genes impacting calcium and phosphorus metabolism, the immune system, and behavior. Uro

Externí odkaz: https://doaj.org/article/97eedda4d71a409f88143dc9029b252a