Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Zhefan Stephen, Chen"'
Autor:
Zhefan Stephen Chen, Mingxi Ou, Stephanie Taylor, Ruxandra Dafinca, Shaohong Isaac Peng, Kevin Talbot, Ho Yin Edwin Chan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The GGGGCC hexanucleotide repeat expansion mutation in the chromosome 9 open reading frame 72 (C9orf72) gene is a major genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD). In this study, we demonstrate tha
Externí odkaz:
https://doaj.org/article/b3e750fa439f44bc949df9182694974b
Autor:
Shaohong Isaac Peng, Lok I. Leong, Jacquelyne Ka-Li Sun, Zhefan Stephen Chen, Hei-Man Chow, Ho Yin Edwin Chan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 102-115 (2022)
Polyglutamine (polyQ) diseases, including spinocerebellar ataxias and Huntington’s disease, are progressive neurodegenerative disorders caused by CAG triplet-repeat expansion in the coding regions of disease-associated genes. In this study, we foun
Externí odkaz:
https://doaj.org/article/742fe03b25504f89bb4861cfdbe55b3d
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-19 (2021)
Abstract Polyglutamine (polyQ) diseases comprise Huntington’s disease and several subtypes of spinocerebellar ataxia, including spinocerebellar ataxia type 3 (SCA3). The genomic expansion of coding CAG trinucleotide sequence in disease genes leads
Externí odkaz:
https://doaj.org/article/ce016e87a79b40d29b9c705bf2379d0c
Autor:
Ashraf Yahia, Zhefan Stephen Chen, Ammar E. Ahmed, Sara Emad, Rawaa Adil, Rayan Abubaker, Shaimaa Omer M. A. Taha, Mustafa A. Salih, Liena Elsayed, Ho Yin Edwin Chan, Giovanni Stevanin
Publikováno v:
BMC Neurology, Vol 21, Iss 1, Pp 1-5 (2021)
Abstract Background CCDC88C is a ubiquitously expressed protein with multiple functions, including roles in cell polarity and the development of dendrites in the nervous system. Bi-allelic mutations in the CCDC88C gene cause autosomal recessive conge
Externí odkaz:
https://doaj.org/article/b8c746913ddd48ba939b314929b99bd2
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Biomass polyphenols are bio-active macromolecules with distinct chemical structures in a variety of biomass. In recent years, the study of biomass polyphenols and their application in food and medicine fields has become a research hotspot, which pred
Externí odkaz:
https://doaj.org/article/fdd45fc0dcc942d7973ed85df44de491
Autor:
Qian Zhang, Ying An, Zhefan Stephen Chen, Alex Chun Koon, Kwok-Fai Lau, Jacky Chi Ki Ngo, Ho Yin Edwin Chan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 16, Iss , Pp 172-185 (2019)
One drug, two diseases is a rare and economical therapeutic strategy that is highly desirable in the pharmaceutical industry. We previously reported a 21-amino acid peptide named beta-structured inhibitor for neurodegenerative diseases (BIND) that ca
Externí odkaz:
https://doaj.org/article/93a3c017448d49dfb54ad5fc338c760b
Autor:
Zhefan Stephen Chen, Ho Yin Edwin Chan
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 7, Pp 1148-1151 (2019)
Yin Yang 1 (YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types, including neurons. It controls neuronal differentiation, as well as neuronal specification and migration during the development of th
Externí odkaz:
https://doaj.org/article/91f0d0e951094da2a3f2392c3c9d1d1b
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Lignin-carbohydrate complex (LCC) is the biological macromolecule that has been demonstrated to exert multiple biological functions, including antioxidant, anti-inflammation and anti-tumorigenesis, which support its broad application in the bioengine
Externí odkaz:
https://doaj.org/article/87f9294189a14446a405932ccc63f61f
Autor:
Yuqi Liu, Xucai Wang, Qiming Wu, Wenhui Pei, Miou Jing Teo, Zhefan Stephen Chen, Caoxing Huang
Publikováno v:
International Journal of Biological Macromolecules. 222:994-1006
Lignin is a major phenolic polymer from the plant biomass. Due to its abundant functional groups (carboxyl and hydroxyl groups), lignin could act as an antioxidant, antimicrobial as well as an immune modulator. These remarkable biological properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb59aa46dd32b6060111ca795a5cf52
https://doi.org/10.1016/j.ijbiomac.2022.09.267
https://doi.org/10.1016/j.ijbiomac.2022.09.267
Publikováno v:
Journal of Renewable Materials. 10:1471-1490
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e671446dd621d6ec5e7bcbc8607ae215
https://doi.org/10.32604/jrm.2022.018811
https://doi.org/10.32604/jrm.2022.018811