Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Zhe-Bin Zheng"'
Publikováno v:
Synthesis. 50:4569-4576
Clavaminols are a new class of long-chain 2-amino-3-alkanols that mostly contain 2R,3S-configurations. Owing to their interesting molecular architectures and promising activities, they have become popular targets for synthetic organic chemists. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8830c462661310f34dc8b9924ea80013
https://doi.org/10.1055/s-0037-1610305
https://doi.org/10.1055/s-0037-1610305
Publikováno v:
HETEROCYCLES. 104:1913
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dacabce0e8746ae8bacb70e9d6ccec04
https://doi.org/10.3987/rev-22-985
https://doi.org/10.3987/rev-22-985
Publikováno v:
HETEROCYCLES. 104:215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d74bef22c91597c951dd3e71e43de51
https://doi.org/10.3987/rev-21-969
https://doi.org/10.3987/rev-21-969
Publikováno v:
Tetrahedron: Asymmetry. 28:725-729
Concise stereoselective syntheses of (−)-clavaminol A and deacetyl (+)-clavaminol H have been achieved from simple starting materials. Highlights of the synthesis for (−)-clavaminol A include a highly diastereoselective chelation-controlled hydri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9257e9474e4a275abe903092e0ffba11
https://doi.org/10.1016/j.tetasy.2017.04.004
https://doi.org/10.1016/j.tetasy.2017.04.004
Autor:
Yao Zhongwei, Xiao Liu, Hong Zhang, Yankui Sang, Jing Zhai, Zhe-Bin Zheng, Jin Tian, Deng Qishan, Li Zonghe, Yan Yue, Xiaopeng Hu, Maolin Huang, Caixia Ni
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 65:455-460
Several glutathione derivatives bearing the S-(N-aryl-N-hydroxycarbamoyl) or S-(C-aryl-N-hydroxycarbamoyl) moieties (10, 10', 13-15) were synthesized, characterized, and their human glyoxalase I (hGLO1) inhibitory activity was evaluated. Compound 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd5ef503e4ed7184f810e55c91523e1
https://doi.org/10.1248/cpb.c16-00800
https://doi.org/10.1248/cpb.c16-00800
Autor:
Maolin Huang, Qingchun Diao, Yujiao He, Chunyan Zhou, Xiao Liu, Chunyan Tang, Yan Yue, Zhe-Bin Zheng, Deming Liu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 131, Iss, Pp 110663-(2020)
The glyoxalase system is a ubiquitous enzymatic network which plays important roles in biological life. It consists of glyoxalase 1 (GLO1), glyoxalase 2 (GLO2), and reduced glutathione (GSH), which perform an essential metabolic function in cells by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3fb40463e361c17b0c562a3d52ddc28
https://doi.org/10.1016/j.biopha.2020.110663
https://doi.org/10.1016/j.biopha.2020.110663
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115243
Glyoxalase I (GLO1) is a homodimeric Zn2+-metalloenzyme that catalyses the transformation of methylglyoxal (MG) to d-lacate through the intermediate S-d-lactoylglutathione. Growing evidence indicates that GLO1 has been identified as a potential targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca14e8a75207c2ade73d77d84c9ab5ec
https://doi.org/10.1016/j.bmc.2019.115243
https://doi.org/10.1016/j.bmc.2019.115243
Publikováno v:
Synthesis; 2018, Vol. 50 Issue 23, p4569-4576, 8p
Autor:
Caixia Ni, Deng Qishan, Mingguang Mo, Bichong Liu, Shi Qing, Yankui Sang, Zhe-Bin Zheng, Donald J. Creighton, Li Zonghe
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(21)
The zinc metalloenzyme glyoxalase I (GlxI) catalyzes the glutathione-dependent inactivation of cytotoxic methylglyoxal. Two competitive bivalent GlxI inhibitors, polyBHG2-62 (Ki=1.0 nM) and polyBHG2-54 (Ki=0.3 nM), were synthesized based on the trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7aac076d01f462387be4f731fed4aec
https://pubmed.ncbi.nlm.nih.gov/26320622
https://pubmed.ncbi.nlm.nih.gov/26320622
Autor:
Julie L. Eiseman, Guozhang Zhu, Donald J. Creighton, Erin Joseph, Heekyung Tak, Zhe-Bin Zheng
Publikováno v:
Bioconjugate Chemistry. 16:598-607
The incorporation of anticancer prodrugs into polyacrylamide conjugates has been shown to improve tumor targeting via the so-called "enhanced permeability and retention" effect. This strategy has now been expanded to include two different classes of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf7fc6fec4df3a985d9e0326ce96d57
https://doi.org/10.1021/bc0499634
https://doi.org/10.1021/bc0499634